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anti-ACVR1 antibody :: Rabbit ACVR1C Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151152
Western Blot (WB)
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACVR1C, Polyclonal Antibody

 Also Known As   

ACVR1C Antibody

 Product Synonym Names    ACVR1C; FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2; Activin receptor type-1; Activin receptor type I; ACTR-I; activin A receptor, type I
 Product Gene Name   

anti-ACVR1 antibody

[Similar Products]
 Antibody/Peptide Pairs    ACVR1C peptide (MBS152334) is used for blocking the activity of ACVR1C antibody (MBS151152)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 135100
 3D Structure    ModBase 3D Structure for Q04771
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1B.
 Purity/Purification    ACVR1C Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    ACVR1C antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of the human ACVR1C.
 Buffer    ACVR1C Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    ACVR1C antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-ACVR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ACVR1 antibody

   ACVR1C Antibody: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1C, also known as ALK7, is a type I activin receptor and plays a role in cell differentiation, growth arrest and apoptosis. ACVR1C can mediate signaling by ligans such as Nodal, GDF-1/3, activin B and activin AB, all of which can also signal through the ubiquitous activin type I receptor ACVR1B (also known as ALK4). ACVR1C is a novel marker specifically expressed during the late phase of adipocyte differentiation. ACVR1C is dispensable for mouse embryogenesis, which suggests alternative functions for this receptor in postnatal development and tissue homeostasis. ACVR1C plays an important role in regulating the functional plasticity of pancreatic islets, negatively affecting beta-cell function by mediating the effects of activin B on Ca2+ signaling.
 Applications Tested/Suitable for anti-ACVR1 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-ACVR1 antibody    ACVR1C antibody can be used for detection of ACVR1C by Western blot at 1 and 2 mug/mL.
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 Western Blot (WB) of anti-ACVR1 antibody    Western blot analysis of ACVR1C in human placenta tissue lysate with ACVR1C antibody at (A) 1 and (B) 2 μg/mL.
anti-ACVR1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ACVR1. It may not necessarily be applicable to this product.
 NCBI GI #    4501895
 NCBI GeneID    90
 NCBI Accession #    NP_001096 [Other Products]
 NCBI GenBank Nucleotide #    NM_001105.4 [Other Products]
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 UniProt Primary Accession #    Q04771 [Other Products]
 UniProt Related Accession #    Q04771 [Other Products]
 Molecular Weight    57,153 Da
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 NCBI Official Full Name    activin receptor type-1
 NCBI Official Synonym Full Names    activin A receptor, type I
 NCBI Official Symbol    ACVR1 [Similar Products]
 NCBI Official Synonym Symbols   
FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2
[Similar Products]
 NCBI Protein Information    activin receptor type-1; activin receptor type I; hydroxyalkyl-protein kinase; activin receptor-like kinase 2; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1
 UniProt Protein Name    Activin receptor type-1
 UniProt Synonym Protein Names   
Activin receptor type I; ACTR-I; Activin receptor-like kinase 2; ALK-2; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I
 Protein Family    Activin receptor
 UniProt Gene Name    ACVR1 [Similar Products]
 UniProt Synonym Gene Names    ACVRLK2; ACTR-I; ALK-2; SKR1; TSR-I [Similar Products]
 UniProt Entry Name    ACVR1_HUMAN
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 NCBI Summary for ACVR1    Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACVR1    ALK2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. Interacts with FKBP1A. Interacts with FCHO1. Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; EC 2.7.11.30; Protein kinase, TKL; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 2q23-q24

Cellular Component: apical part of cell; integral to plasma membrane; activin receptor complex

Molecular Function: protein homodimerization activity; metal ion binding; peptide hormone binding; transmembrane receptor protein serine/threonine kinase activity; protein kinase activity; protein serine/threonine kinase activity; protein binding; activin receptor activity, type I; transforming growth factor beta receptor activity, type I; transforming growth factor beta binding; activin binding; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; protein amino acid phosphorylation; germ cell development; BMP signaling pathway; transforming growth factor beta receptor signaling pathway; neural crest cell migration; pharyngeal system development; in utero embryonic development; peptidyl-threonine phosphorylation; gastrulation with mouth forming second; positive regulation of bone mineralization; negative regulation of signal transduction; patterning of blood vessels; negative regulation of activin receptor signaling pathway; positive regulation of osteoblast differentiation; mesoderm formation; regulation of skeletal muscle development; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of ossification; determination of left/right symmetry; urogenital system development; acute inflammatory response; G1/S transition of mitotic cell cycle

Disease: Fibrodysplasia Ossificans Progressiva
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 Research Articles on ACVR1    1. compounds demonstrated consistent binding to a panel of mutant and wild-type ALK2 proteins
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACVR1 antibodyPathways associated with anti-ACVR1 antibody
 Reference Product  PubMed Publications
 BMPR2 antibody  >36 publications with ACVR1 and BMPR2
 SMAD1 antibody  >34 publications with ACVR1 and SMAD1
 BMP7 antibody  >24 publications with ACVR1 and BMP7
 BMP2 antibody  >23 publications with ACVR1 and BMP2
 SMAD5 antibody  >11 publications with ACVR1 and SMAD5
 ACVR2A antibody  >7 publications with ACVR1 and ACVR2A
 FKBP1A antibody  >2 publications with ACVR1 and FKBP1A
 INHBA antibody  >1 publications with ACVR1 and INHBA
 SMAD9 antibody  >1 publications with ACVR1 and SMAD9
 Products by Pathway  Pathway Diagram
 ALK1 Pathway antibodies  ALK1 Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 ALK2 Signaling Events Pathway antibodies  ALK2 Signaling Events Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
Diseases associated with anti-ACVR1 antibodyOrgans/Tissues associated with anti-ACVR1 antibody
 Disease Name  Pubmed Publications
 Myositis Ossificans Antibodies  >80 publications with ACVR1 and Myositis Ossificans
 Nervous System Diseases Antibodies  >15 publications with ACVR1 and Nervous System Diseases
 Glioma Antibodies  >14 publications with ACVR1 and Glioma
 Disease Models, Animal Antibodies  >11 publications with ACVR1 and Disease Models, Animal
 Inflammation Antibodies  >10 publications with ACVR1 and Inflammation
 Heart Diseases Antibodies  >8 publications with ACVR1 and Heart Diseases
 Breast Neoplasms Antibodies  >5 publications with ACVR1 and Breast Neoplasms
 Astrocytoma Antibodies  >4 publications with ACVR1 and Astrocytoma
 Hypertension Antibodies  >4 publications with ACVR1 and Hypertension
 Anemia Antibodies  >3 publications with ACVR1 and Anemia
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >156 publications with ACVR1 and Bone
 Muscle Antibodies  >46 publications with ACVR1 and Muscle
 Connective Tissue Antibodies  >26 publications with ACVR1 and Connective Tissue
 Blood Antibodies  >19 publications with ACVR1 and Blood
 Brain Antibodies  >19 publications with ACVR1 and Brain
 Vascular Antibodies  >16 publications with ACVR1 and Vascular
 Embryonic Tissue Antibodies  >15 publications with ACVR1 and Embryonic Tissue
 Heart Antibodies  >12 publications with ACVR1 and Heart
 Lung Antibodies  >8 publications with ACVR1 and Lung
 Ovary Antibodies  >7 publications with ACVR1 and Ovary
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