NP_001265508.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,713 Da
NCBI Official Full Name
activin receptor type-2A isoform 1
NCBI Official Synonym Full Names
activin A receptor, type IIA
NCBI Protein Information
activin receptor type-2A
UniProt Protein Name
Activin receptor type-2A
UniProt Synonym Protein Names
Activin receptor type IIA; ACTR-IIA; ACTRIIA
UniProt Synonym Gene Names
UniProt Entry Name
AVR2A_HUMAN
NCBI Summary for ACVR2A
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]
UniProt Comments for ACVR2A
ACVR2A: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; EC 2.7.11.30; Motility/polarity/chemotaxis; Membrane protein, integral; TKL group; STKR family; Type2 subfamily
Chromosomal Location of Human Ortholog: 2q22.3
Cellular Component: cell surface; integral to plasma membrane; cytoplasm; plasma membrane; receptor complex
Molecular Function: transforming growth factor beta receptor activity; protein serine/threonine kinase activity; activin receptor activity; protein binding; protein self-association; growth factor binding; metal ion binding; activin binding; coreceptor activity; ATP binding; transmembrane receptor protein serine/threonine kinase activity; PDZ domain binding; receptor signaling protein serine/threonine kinase activity
Biological Process: embryonic skeletal development; positive regulation of erythrocyte differentiation; regulation of BMP signaling pathway; activin receptor signaling pathway; Sertoli cell proliferation; gastrulation with mouth forming second; positive regulation of bone mineralization; protein amino acid phosphorylation; anterior/posterior pattern formation; BMP signaling pathway; positive regulation of osteoblast differentiation; positive regulation of activin receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; spermatogenesis; mesoderm development; regulation of nitric-oxide synthase activity; sperm ejaculation; positive regulation of protein amino acid phosphorylation; determination of left/right symmetry; penile erection
Research Articles on ACVR2A
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Products associated with anti-ACVR2A antibody
Pathways associated with anti-ACVR2A antibody
Diseases associated with anti-ACVR2A antibody
Organs/Tissues associated with anti-ACVR2A antibody
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