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anti-ACVRL1 antibody :: Rabbit anti-Human, mouse ACVRL1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9208190
Unit / Price
0.08 mL  /  $155 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACVRL1, Polyclonal Antibody

 Also Known As   

ACVRL1 Antibody (N-term)

 Product Synonym Names    Serine/threonine-protein kinase receptor R3; SKR3; Activin receptor-like kinase 1; ALK-1; TGF-B superfamily receptor type I; TSR-I; ACVRL1; ACVRLK1; ALK1
 Product Gene Name   

anti-ACVRL1 antibody

[Similar Products]
 Antibody/Peptide Pairs    ACVRL1 peptide (MBS9227275) is used for blocking the activity of ACVRL1 antibody (MBS9208190)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    38-68
 OMIM    600376
 3D Structure    ModBase 3D Structure for P37023
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human, mouse
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 Specificity    This ACVRL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-68 amino acids from the N-terminal region of human ACVRL1.
 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
 Concentration    Vial Concentration: 2 (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-ACVRL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ACVRL1 antibody

   ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. This protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
 Product Categories/Family for anti-ACVRL1 antibody    Cancer; Cardiovascular; Metabolism; Signal Transduction
 Applications Tested/Suitable for anti-ACVRL1 antibody   

Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC)

 Application Notes for anti-ACVRL1 antibody    WB~~1:1000
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 Western Blot (WB) of anti-ACVRL1 antibody    Western blot of ACVRL1 Pab. TOP LEFT: Mouse heart tissue lysate.
anti-ACVRL1 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-ACVRL1 antibody    Western blot analysis of ACVRL1 (arrow) using rabbit polyclonal ACVRL1 Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ACVRL1 gene (Lane 2) (Origene Technologies).
anti-ACVRL1 antibody Western Blot (WB) (WB) image
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 Flow Cytometry (FC/FACS) of anti-ACVRL1 antibody    Flow cytometric analysis of HepG2 cells using ACVRL1 Antibody (N-term) (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-ACVRL1 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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 Immunohistochemistry (IHC) of anti-ACVRL1 antibody    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
anti-ACVRL1 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-ACVRL1 antibody    human chondrocytes (C28/I2 cells), transfected with empty vector (lane 1, 3) or ACVRL1(lane 2, 4). RIPA lysis buffer, 20 ug/lane of protein, primary antibody dilution 1:1000, blocking solution is 5% milk in TBST (lane 1 and 2), 5% BSA in TBST (lane 3 and 4). Data courtesy of Kenneth Finnson, Montreal General Hospital.
anti-ACVRL1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ACVRL1. It may not necessarily be applicable to this product.
 NCBI GI #    116734712
 NCBI GeneID    94
 NCBI Accession #    NP_000011.2 [Other Products]
 NCBI Related Accession #    NP_001070869.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000020.2 [Other Products]
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 UniProt Primary Accession #    P37023 [Other Products]
 UniProt Secondary Accession #    A6NGA8 [Other Products]
 UniProt Related Accession #    P37023 [Other Products]
 Molecular Weight    56124
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 NCBI Official Full Name    serine/threonine-protein kinase receptor R3
 NCBI Official Synonym Full Names    activin A receptor type II-like 1
 NCBI Official Symbol    ACVRL1 [Similar Products]
 NCBI Official Synonym Symbols   
HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase receptor R3
 UniProt Protein Name    Serine/threonine-protein kinase receptor R3
 UniProt Synonym Protein Names   
Activin receptor-like kinase 1; ALK-1; TGF-B superfamily receptor type I; TSR-I
 Protein Family    Serine/threonine-protein kinase receptor
 UniProt Gene Name    ACVRL1 [Similar Products]
 UniProt Synonym Gene Names    ACVRLK1; ALK1; SKR3; ALK-1; TSR-I [Similar Products]
 UniProt Entry Name    ACVL1_HUMAN
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 NCBI Summary for ACVRL1    This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACVRL1    ALK1: a kinase of the STKR family. A type I cell-surface receptor for the TGF-beta superfamily of ligands including Activin A. Highly expressed in human placenta and lung. Deficiency causes hemorrhagic telangiectasia type 2 also known as Rendu-Osler-Weber syndrome 2.

Protein type: Protein kinase, TKL; Kinase, protein; EC 2.7.11.30; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: cell surface; cell soma; integral to plasma membrane; dendrite

Molecular Function: metal ion binding; protein kinase binding; transmembrane receptor protein serine/threonine kinase activity; transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; activin receptor activity, type I; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; activin binding; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: protein heterooligomerization; blood circulation; positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; negative regulation of cell adhesion; regulation of blood vessel endothelial cell migration; signal transduction; protein amino acid phosphorylation; BMP signaling pathway; negative regulation of cell proliferation; positive regulation of endothelial cell differentiation; negative regulation of endothelial cell differentiation; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; regulation of blood pressure; lymphangiogenesis; angiogenesis; negative regulation of cell migration; positive regulation of BMP signaling pathway; regulation of DNA replication; regulation of endothelial cell proliferation; in utero embryonic development; negative regulation of focal adhesion formation; negative regulation of blood vessel endothelial cell migration; blood vessel maturation; blood vessel endothelial cell proliferation during sprouting angiogenesis; positive regulation of angiogenesis; positive regulation of chondrocyte differentiation; negative regulation of endothelial cell proliferation; blood vessel remodeling; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; wound healing, spreading of epidermal cells

Disease: Telangiectasia, Hereditary Hemorrhagic, Type 2
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Product References and Citations for anti-ACVRL1 antibody

   Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).
Berg, J.N., et al., Am. J. Hum. Genet. 61(1):60-67 (1997).
Johnson, D.W., et al., Nat. Genet. 13(2):189-195 (1996).
ten Dijke, P., et al., Oncogene 8(10):2879-2887 (1993).
Attisano, L., et al., Cell 75(4):671-680 (1993).
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 Research Articles on ACVRL1    1. Endoglin and ACVRL1 contribute to several novel networks, including TGF-beta dependent and independent ones, critical for vascular function and potentially defective in hereditary hemorrhagic telangiectasia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACVRL1 antibodyDiseases associated with anti-ACVRL1 antibody
 Reference Product  PubMed Publications
 ENG antibody  >177 publications with ACVRL1 and ENG
 SMAD1 antibody  >51 publications with ACVRL1 and SMAD1
 TGFB1 antibody  >44 publications with ACVRL1 and TGFB1
 SMAD5 antibody  >19 publications with ACVRL1 and SMAD5
 TGFBR2 antibody  >8 publications with ACVRL1 and TGFBR2
 TGFB3 antibody  >1 publications with ACVRL1 and TGFB3
 SMAD9 antibody  >1 publications with ACVRL1 and SMAD9
 ACVR2A antibody  >1 publications with ACVRL1 and ACVR2A
 ACVR2B antibody  >1 publications with ACVRL1 and ACVR2B
 Disease Name  Pubmed Publications
 Telangiectasia, Hereditary Hemorrhagic Antibodies  >214 publications with ACVRL1 and Telangiectasia, Hereditary Hemorrhagic
 Cardiovascular Diseases Antibodies  >202 publications with ACVRL1 and Cardiovascular Diseases
 Hypertension Antibodies  >57 publications with ACVRL1 and Hypertension
 Lung Diseases Antibodies  >54 publications with ACVRL1 and Lung Diseases
 Heart Diseases Antibodies  >22 publications with ACVRL1 and Heart Diseases
 Fibrosis Antibodies  >15 publications with ACVRL1 and Fibrosis
 Inflammation Antibodies  >13 publications with ACVRL1 and Inflammation
 Liver Diseases Antibodies  >11 publications with ACVRL1 and Liver Diseases
 Granuloma Antibodies  >8 publications with ACVRL1 and Granuloma
 Atherosclerosis Antibodies  >8 publications with ACVRL1 and Atherosclerosis
Organs/Tissues associated with anti-ACVRL1 antibody
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >235 publications with ACVRL1 and Vascular
 Bone Antibodies  >97 publications with ACVRL1 and Bone
 Brain Antibodies  >55 publications with ACVRL1 and Brain
 Lung Antibodies  >52 publications with ACVRL1 and Lung
 Heart Antibodies  >43 publications with ACVRL1 and Heart
 Liver Antibodies  >43 publications with ACVRL1 and Liver
 Muscle Antibodies  >39 publications with ACVRL1 and Muscle
 Skin Antibodies  >33 publications with ACVRL1 and Skin
 Kidney Antibodies  >14 publications with ACVRL1 and Kidney
 Connective Tissue Antibodies  >9 publications with ACVRL1 and Connective Tissue
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