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anti-ACY1 antibody :: Rabbit anti-Human ACY1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9127408
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACY1, Polyclonal Antibody

 Also Known As   

ACY1 Polyclonal Antibody

 Product Synonym Names    ACY-1; ACY1D; HEL-S-5
 Product Gene Name   

anti-ACY1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 609924
 3D Structure    ModBase 3D Structure for Q03154
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human ACY1
 Calculated Molecular Weight    45kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-ACY1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ACY1 antibody

   This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.
 Product Categories/Family for anti-ACY1 antibody    Polyclonal
 Applications Tested/Suitable for anti-ACY1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-ACY1 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
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 Western Blot (WB) of anti-ACY1 antibody    Western blot analysis of extracts of various cell lines, using ACY1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
anti-ACY1 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-ACY1 antibody    Immunofluorescence analysis of HeLa cells using ACY1 antibody. Blue: DAPI for nuclear staining.
anti-ACY1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for ACY1. It may not necessarily be applicable to this product.
 NCBI GI #    461466
 NCBI GeneID    95
 NCBI Accession #    Q03154.1 [Other Products]
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 UniProt Primary Accession #    Q03154 [Other Products]
 UniProt Secondary Accession #    C9J6I6; C9J9D8; C9JWD4 [Other Products]
 UniProt Related Accession #    Q03154 [Other Products]
 Molecular Weight    408
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 NCBI Official Full Name    Aminoacylase-1
 NCBI Official Synonym Full Names    aminoacylase 1
 NCBI Official Symbol    ACY1 [Similar Products]
 NCBI Official Synonym Symbols   
ACY-1; ACY1D; HEL-S-5
[Similar Products]
 NCBI Protein Information    aminoacylase-1; epididymis secretory protein Li 5; N-acyl-L-amino-acid amidohydrolase
 UniProt Protein Name    Aminoacylase-1
 UniProt Synonym Protein Names   
N-acyl-L-amino-acid amidohydrolase
 Protein Family    Aminoacylase
 UniProt Gene Name    ACY1 [Similar Products]
 UniProt Synonym Gene Names    ACY-1 [Similar Products]
 UniProt Entry Name    ACY1_HUMAN
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 NCBI Summary for ACY1    This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Nov 2010]
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 UniProt Comments for ACY1    ACY1: Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). Defects in ACY1 are the cause of aminoacylase-1 deficiency (ACY1D). ACY1D results in a metabolic disorder manifesting with encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked muscular hypotonia or normal clinical features. Epileptic seizures are a frequent feature. All affected individuals exhibit markedly increased urinary excretion of several N-acetylated amino acids. Belongs to the peptidase M20A family.

Protein type: Hydrolase; EC 3.5.1.14; Amino Acid Metabolism - arginine and proline

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: cytosol

Molecular Function: metallopeptidase activity; metal ion binding; aminoacylase activity

Biological Process: amino acid metabolic process; xenobiotic metabolic process; proteolysis

Disease: Aminoacylase 1 Deficiency
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 Research Articles on ACY1    1. ACY1 acts as a tumor suppressor in hepatocellular carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACY1 antibodyPathways associated with anti-ACY1 antibody
 Reference Product  PubMed Publications
 ASPA antibody  >1 publications with ACY1 and ASPA
 OTC antibody  >1 publications with ACY1 and OTC
 SPHK1 antibody  >1 publications with ACY1 and SPHK1
 Products by Pathway  Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 Aflatoxin Activation And Detoxification Pathway antibodies  Aflatoxin Activation And Detoxification Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Defective ACY1 Causes Encephalopathy Pathway antibodies  Defective ACY1 Causes Encephalopathy Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
Diseases associated with anti-ACY1 antibodyOrgans/Tissues associated with anti-ACY1 antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >8 publications with ACY1 and Adenocarcinoma
 Carcinoma, Renal Cell Antibodies  >6 publications with ACY1 and Carcinoma, Renal Cell
 Liver Diseases Antibodies  >4 publications with ACY1 and Liver Diseases
 Kidney Diseases Antibodies  >4 publications with ACY1 and Kidney Diseases
 Liver Neoplasms Antibodies  >4 publications with ACY1 and Liver Neoplasms
 Kidney Neoplasms Antibodies  >3 publications with ACY1 and Kidney Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with ACY1 and Carcinoma, Hepatocellular
 Aminoacylase 1 deficiency Antibodies  >3 publications with ACY1 and Aminoacylase 1 deficiency
 Neoplasms, Experimental Antibodies  >2 publications with ACY1 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >1 publications with ACY1 and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >8 publications with ACY1 and Lung
 Kidney Antibodies  >7 publications with ACY1 and Kidney
 Liver Antibodies  >6 publications with ACY1 and Liver
 Blood Antibodies  >3 publications with ACY1 and Blood
 Brain Antibodies  >2 publications with ACY1 and Brain
 Muscle Antibodies  >1 publications with ACY1 and Muscle
 Lymph Node Antibodies  >1 publications with ACY1 and Lymph Node
 Embryonic Tissue Antibodies  >1 publications with ACY1 and Embryonic Tissue
 Bone Antibodies  >1 publications with ACY1 and Bone
 Prostate Antibodies  >1 publications with ACY1 and Prostate
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