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anti-ADA antibody :: Rabbit anti-Human ADA Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9210674
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADA, Polyclonal Antibody

★Popular Item★
 Also Known As   

ADA Antibody (C-term)

 Product Synonym Names    Adenosine deaminase; Adenosine aminohydrolase; ADA; ADA1
 Product Gene Name   

anti-ADA antibody

[Similar Products]
 Antibody/Peptide Pairs    ADA peptide (MBS9218533) is used for blocking the activity of ADA antibody (MBS9210674)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    287-314
 OMIM    102700
 3D Structure    ModBase 3D Structure for P00813
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This ADA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-314 amino acids from the C-terminal region of human ADA.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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 Antigen Type    Synthetic Peptide
 Crown Antibody    Yes
 Antigen Source    HUMAN
 Function    Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte- epithelial cell adhesion.
  Cellular Location    Cell membrane; Peripheral membrane protein; Extracellular side. Cell junction. Cytoplasmic vesicle lumen. Cytoplasm. Note=Colocalized with DPP4 at the cell junction in lymphocyte-epithelial cell adhesion
  Tissue Location    Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time of weaning, in gastrointestinal tissues
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-ADA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ADA antibody

   This gene encodes an enzyme that catalyzes the hydrolysis
of adenosine to inosine. Various mutations have been described for
this gene and have been linked to human diseases. Deficiency in
this enzyme causes a form of severe combined immunodeficiency
disease (SCID), in which there is dysfunction of both B and T
lymphocytes with impaired cellular immunity and decreased
production of immunoglobulins, whereas elevated levels of this
enzyme have been associated with congenital hemolytic anemia.
 Product Categories/Family for anti-ADA antibody    Crown Antibodies; Cancer; Metabolism; Neuroscience
 Applications Tested/Suitable for anti-ADA antibody   

Flow Cytometry (FC/FACS), Western Blot (WB)

 Application Notes for anti-ADA antibody    WB~~1:1000
FC~~1:10~50
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 Western Blot (WB) of anti-ADA antibody    ADA Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the ADA antibody detected the ADA protein (arrow).
anti-ADA antibody Western Blot (WB) (WB) image
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 Flow Cytometry (FC/FACS) of anti-ADA antibody    ADA Antibody (C-term) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-ADA antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for ADA. It may not necessarily be applicable to this product.
 NCBI GI #    47078295
 NCBI GeneID    100
 NCBI Accession #    NP_000013.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000022.2 [Other Products]
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 UniProt Primary Accession #    P00813 [Other Products]
 UniProt Secondary Accession #    Q53F92; Q6LA59 [Other Products]
 UniProt Related Accession #    P00813 [Other Products]
 Molecular Weight    40764
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 NCBI Official Full Name    adenosine deaminase
 NCBI Official Synonym Full Names    adenosine deaminase
 NCBI Official Symbol    ADA [Similar Products]
 NCBI Protein Information    adenosine deaminase
 UniProt Protein Name    Adenosine deaminase
 UniProt Synonym Protein Names   
Adenosine aminohydrolase
 Protein Family    ADAM
 UniProt Gene Name    ADA [Similar Products]
 UniProt Synonym Gene Names    ADA1 [Similar Products]
 UniProt Entry Name    ADA_HUMAN
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 NCBI Summary for ADA    This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADA    ADA: a enzyme that converts adenosine + H2O into inosine + NH3. Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time of weaning, in gastrointestinal tissues. Genetic ADA deficiencies are a cause of autosomal recessive severe combined immuno-deficiency (SCID). Hereditary hemolytic anemia is caused by expression levels in erythrocytes 50-70 times greater than the norm.

Protein type: Nucleotide Metabolism - purine; EC 3.5.4.4; Hydrolase

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: dendrite cytoplasm; extracellular space; cell surface; cell soma; membrane; lysosome; cytoplasm; plasma membrane; cell junction; cytosol; external side of plasma membrane

Molecular Function: adenosine deaminase activity; protein binding; zinc ion binding; purine nucleoside binding

Biological Process: negative regulation of circadian sleep/wake cycle, non-REM sleep; T cell activation; adenosine catabolic process; deoxyadenosine catabolic process; response to morphine; positive regulation of calcium-mediated signaling; purine salvage; histamine secretion; positive regulation of T cell differentiation in the thymus; purine ribonucleoside monophosphate biosynthetic process; response to vitamin E; regulation of cell-cell adhesion mediated by integrin; positive regulation of T cell receptor signaling pathway; negative regulation of mature B cell apoptosis; positive regulation of germinal center formation; positive regulation of B cell proliferation; hypoxanthine salvage; negative regulation of adenosine receptor signaling pathway; positive regulation of smooth muscle contraction; embryonic gut development; placenta development; aging; Peyer's patch development; response to drug; nucleobase, nucleoside and nucleotide metabolic process; dATP catabolic process; positive regulation of heart rate; liver development; negative regulation of leukocyte migration; purine base metabolic process; trophectodermal cell differentiation; purine nucleotide salvage; xanthine biosynthetic process; response to hydrogen peroxide; negative regulation of inflammatory response; response to hypoxia; inosine biosynthetic process; germinal center B cell differentiation; alveolus development; positive regulation of alpha-beta T cell differentiation

Disease: Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-negative, B Cell-negative, Nk Cell-negative, Due To Adenosine Deaminase Deficiency
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Product References and Citations for anti-ADA antibody

   Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Gloria-Bottini, F., et al. Am. J. Med. Sci. 340(2):103-108(2010)
Levine, A.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1812-1821(2010)
Spina, C., et al. Cancer Invest. (2010) In press :
Ri, G., et al. Anticancer Res. 30(6):2347-2349(2010)
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 Research Articles on ADA    1. We conclude that ADA is an effective test for the diagnosis of pleural tuberculosis; ADA values varied with age in our study population
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADA antibodyDiseases associated with anti-ADA antibody
 Reference Product  PubMed Publications
 PNP antibody  >160 publications with ADA and PNP
 DCK antibody  >10 publications with ADA and DCK
 MYB antibody  >6 publications with ADA and MYB
 ADK antibody  >6 publications with ADA and ADK
 NT5E antibody  >3 publications with ADA and NT5E
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >468 publications with ADA and Nervous System Diseases
 Necrosis Antibodies  >240 publications with ADA and Necrosis
 Brain Diseases Antibodies  >230 publications with ADA and Brain Diseases
 Inflammation Antibodies  >227 publications with ADA and Inflammation
 Heart Diseases Antibodies  >208 publications with ADA and Heart Diseases
 Hypertension Antibodies  >180 publications with ADA and Hypertension
 Glucose Intolerance Antibodies  >136 publications with ADA and Glucose Intolerance
 Disease Models, Animal Antibodies  >136 publications with ADA and Disease Models, Animal
 Pain Antibodies  >121 publications with ADA and Pain
 Liver Diseases Antibodies  >97 publications with ADA and Liver Diseases
Organs/Tissues associated with anti-ADA antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2513 publications with ADA and Blood
 Bone Antibodies  >333 publications with ADA and Bone
 Heart Antibodies  >286 publications with ADA and Heart
 Brain Antibodies  >280 publications with ADA and Brain
 Lung Antibodies  >236 publications with ADA and Lung
 Bone Marrow Antibodies  >229 publications with ADA and Bone Marrow
 Liver Antibodies  >218 publications with ADA and Liver
 Kidney Antibodies  >167 publications with ADA and Kidney
 Spleen Antibodies  >156 publications with ADA and Spleen
 Skin Antibodies  >148 publications with ADA and Skin
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