NP_001159577.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,054 Da
NCBI Official Full Name
transcriptional adapter 2-alpha isoform a
NCBI Official Synonym Full Names
transcriptional adaptor 2A
NCBI Official Synonym Symbols
ADA2; ADA2A; KL04P; hADA2; TADA2L [Similar Products]
NCBI Protein Information
transcriptional adapter 2-alpha
UniProt Protein Name
Transcriptional adapter 2-alpha
UniProt Synonym Protein Names
Transcriptional adapter 2-like; ADA2-like protein
UniProt Synonym Gene Names
UniProt Entry Name
TAD2A_HUMAN
NCBI Summary for ADA2L
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009]
UniProt Comments for ADA2L
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling.
Research Articles on ADA2L
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Products associated with anti-ADA2L antibody
Pathways associated with anti-ADA2L antibody
Diseases associated with anti-ADA2L antibody
Organs/Tissues associated with anti-ADA2L antibody
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