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anti-ADAM 17 antibody :: Rabbit ADAM 17 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9409378
Western Blot (WB)
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADAM 17, Polyclonal Antibody

★Popular Item★
 Also Known As   

ADAM 17 (Thr735) Antibody

 Product Synonym Names    CSVP, TACE, NISBD, ADAM18, CD156B
 Product Gene Name   

anti-ADAM 17 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603639
 3D Structure    ModBase 3D Structure for P78536
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    The antibody detects endogenous level of ADAM 17 only when phosphorylated at Threonine 735.
 Purity/Purification    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
 Form/Format    Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1.0 mg/ml (lot specific)
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 Immunogen Type    Peptide-KLH
 Immunogen Description    Peptide sequence around phosphorylation site of Threonine 735
 Modification    Phospho-Thr735
 Target Name    ADAM17
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 Preparation and Storage    Store at -20 degree C/1 year
 Other Notes    Small volumes of anti-ADAM 17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ADAM 17 antibody

   Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway.
 Product Categories/Family for anti-ADAM 17 antibody    Phospho-specific Ab
 Applications Tested/Suitable for anti-ADAM 17 antibody   

Western Blot (WB)

 Application Notes for anti-ADAM 17 antibody    Western blotting: 1:500~1:1000
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 Western Blot (WB) of anti-ADAM 17 antibody    Western blot analysis of extracts from K562 cells treated with UV using ADAM 17 (Phospho-Thr735) Antibody.The lane on the left is treated with the antigen-specific peptide.
anti-ADAM 17 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ADAM 17. It may not necessarily be applicable to this product.
 NCBI GI #    73747889
 NCBI GeneID    6868
 NCBI Accession #    NP_003174.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_003183.4 [Other Products]
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 UniProt Primary Accession #    P78536 [Other Products]
 UniProt Secondary Accession #    O60226 [Other Products]
 UniProt Related Accession #    P78536 [Other Products]
 Molecular Weight    78,543 Da
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 NCBI Official Full Name    disintegrin and metalloproteinase domain-containing protein 17 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase domain 17
 NCBI Official Symbol    ADAM17 [Similar Products]
 NCBI Official Synonym Symbols   
CSVP; TACE; NISBD; ADAM18; CD156B; NISBD1
[Similar Products]
 NCBI Protein Information    disintegrin and metalloproteinase domain-containing protein 17
 UniProt Protein Name    Disintegrin and metalloproteinase domain-containing protein 17
 UniProt Synonym Protein Names   
Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD_antigen: CD156b
 Protein Family    ADAM 17-like protease
 UniProt Gene Name    ADAM17 [Similar Products]
 UniProt Synonym Gene Names    CSVP; TACE; ADAM 17 [Similar Products]
 UniProt Entry Name    ADA17_HUMAN
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 NCBI Summary for ADAM 17    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADAM 17    TACE: a type I membrane protein with disintegrin and metalloprotease activity. An ubiquitously expressed ectoenzyme of peptidase family M12B. Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Possesses a narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha) to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, and the amyloid precursor protein. Also involved in the activation of Notch pathway. Binds 1 zinc ion per subunit. Two splice variant isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; EC 3.4.24.86; Protease

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: focal adhesion; cell surface; membrane; integral to plasma membrane; cytoplasm; apical plasma membrane; plasma membrane; intercellular junction; lipid raft; actin cytoskeleton

Molecular Function: integrin binding; protein binding; interleukin-6 receptor binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; Notch binding; SH3 domain binding; PDZ domain binding

Biological Process: extracellular matrix organization and biogenesis; nerve growth factor receptor signaling pathway; neutrophil mediated immunity; T cell differentiation in the thymus; cell motility involved in cell locomotion; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; proteolysis; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; extracellular matrix disassembly; positive regulation of epidermal growth factor receptor activity; positive regulation of cell proliferation; germinal center formation; negative regulation of interleukin-8 production; cell adhesion; epidermal growth factor receptor signaling pathway; spleen development; response to drug; Notch signaling pathway; response to high density lipoprotein stimulus; membrane protein intracellular domain proteolysis; membrane protein ectodomain proteolysis; positive regulation of transforming growth factor beta receptor signaling pathway; Notch receptor processing; positive regulation of cell motility; positive regulation of cell growth; positive regulation of chemokine production; collagen catabolic process; regulation of mast cell apoptosis; PMA-inducible membrane protein ectodomain proteolysis; B cell differentiation; response to hypoxia; cell adhesion mediated by integrin; positive regulation of protein amino acid phosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of cell migration; wound healing, spreading of epidermal cells

Disease: Inflammatory Skin And Bowel Disease, Neonatal, 1
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 Research Articles on ADAM 17    1. Human NOTCH2 but not mouse Notch2 is resistant to negative regulatory region perturbation and ligand-independent activation by Adam17.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADAM 17 antibodyPathways associated with anti-ADAM 17 antibody
 Reference Product  PubMed Publications
 EGFR antibody  >153 publications with ADAM 17 and EGFR
 TIMP3 antibody  >23 publications with ADAM 17 and TIMP3
 NOTCH1 antibody  >15 publications with ADAM 17 and NOTCH1
 ERBB2 antibody  >7 publications with ADAM 17 and ERBB2
 ERBB4 antibody  >2 publications with ADAM 17 and ERBB4
 PSEN2 antibody  >1 publications with ADAM 17 and PSEN2
 NCSTN antibody  >1 publications with ADAM 17 and NCSTN
 NOTCH3 antibody  >1 publications with ADAM 17 and NOTCH3
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies  Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
Diseases associated with anti-ADAM 17 antibodyOrgans/Tissues associated with anti-ADAM 17 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >557 publications with ADAM 17 and Necrosis
 Inflammation Antibodies  >133 publications with ADAM 17 and Inflammation
 Disease Models, Animal Antibodies  >31 publications with ADAM 17 and Disease Models, Animal
 Breast Neoplasms Antibodies  >28 publications with ADAM 17 and Breast Neoplasms
 Liver Diseases Antibodies  >26 publications with ADAM 17 and Liver Diseases
 Kidney Diseases Antibodies  >24 publications with ADAM 17 and Kidney Diseases
 Atherosclerosis Antibodies  >23 publications with ADAM 17 and Atherosclerosis
 Neoplasm Invasiveness Antibodies  >17 publications with ADAM 17 and Neoplasm Invasiveness
 Carcinoma, Hepatocellular Antibodies  >16 publications with ADAM 17 and Carcinoma, Hepatocellular
 Neoplasm Metastasis Antibodies  >16 publications with ADAM 17 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >87 publications with ADAM 17 and Brain
 Kidney Antibodies  >52 publications with ADAM 17 and Kidney
 Lung Antibodies  >48 publications with ADAM 17 and Lung
 Liver Antibodies  >42 publications with ADAM 17 and Liver
 Muscle Antibodies  >41 publications with ADAM 17 and Muscle
 Embryonic Tissue Antibodies  >33 publications with ADAM 17 and Embryonic Tissue
 Ovary Antibodies  >19 publications with ADAM 17 and Ovary
 Prostate Antibodies  >13 publications with ADAM 17 and Prostate
 Bone Marrow Antibodies  >11 publications with ADAM 17 and Bone Marrow
 Eye Antibodies  >11 publications with ADAM 17 and Eye
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