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anti-ADAM10 antibody :: Rabbit anti-Human ADAM10 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1498028 anti-ADAM10 antibody
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADAM10, Polyclonal Antibody

 Also Known As   

ADAM10 Antibody, Biotin conjugated

 Product Synonym Names    Disintegrin and metalloproteinase domain-containing protein 10 (EC:3.4.24.81); ADAM 10; ADAM10; KUZ; MADM; CDw156; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; CD_antigen: CD156c
 Product Gene Name   

anti-ADAM10 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602192
 3D Structure    ModBase 3D Structure for O14672
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Biotin
 Immunogen    Recombinant human Disintegrin and metalloproteinase domain-containing protein 10 protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-16523 / sc-31853 / sc-31855 / sc-16524 / sc-25578
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ADAM10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ADAM10 antibody

   Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.
 Applications Tested/Suitable for anti-ADAM10 antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for ADAM10. It may not necessarily be applicable to this product.
 NCBI GI #    4557251
 NCBI GeneID    102
 NCBI Accession #    NP_001101.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001110.3 [Other Products]
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 UniProt Primary Accession #    O14672 [Other Products]
 UniProt Secondary Accession #    Q10742; Q92650; B4DU28 [Other Products]
 UniProt Related Accession #    O14672 [Other Products]
 Molecular Weight    49,047 Da
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 NCBI Official Full Name    disintegrin and metalloproteinase domain-containing protein 10
 NCBI Official Synonym Full Names    ADAM metallopeptidase domain 10
 NCBI Official Symbol    ADAM10 [Similar Products]
 NCBI Official Synonym Symbols   
RAK; kuz; AD10; AD18; MADM; CD156c; HsT18717
[Similar Products]
 NCBI Protein Information    disintegrin and metalloproteinase domain-containing protein 10
 UniProt Protein Name    Disintegrin and metalloproteinase domain-containing protein 10
 UniProt Synonym Protein Names   
CDw156; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; CD_antigen: CD156c
 Protein Family    Disintegrin and metalloproteinase domain-containing protein
 UniProt Gene Name    ADAM10 [Similar Products]
 UniProt Synonym Gene Names    KUZ; MADM; ADAM 10 [Similar Products]
 UniProt Entry Name    ADA10_HUMAN
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 NCBI Summary for ADAM10    Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADAM10    ADAM10: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth- like factor, ephrin-A2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.

Protein type: Vesicle; Protease; EC 3.4.24.81; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Cell surface

Chromosomal Location of Human Ortholog: 15q22

Cellular Component: cell surface; cytoplasm; focal adhesion; Golgi apparatus; Golgi-associated vesicle; integral to membrane; intracellular membrane-bound organelle; membrane; nucleus; plasma membrane; postsynaptic density; trans-Golgi network

Molecular Function: endopeptidase activity; integrin binding; metalloendopeptidase activity; metallopeptidase activity; protein binding; protein homodimerization activity; protein kinase binding; receptor binding; SH3 domain binding; zinc ion binding

Biological Process: axon guidance; cell-cell signaling; collagen catabolic process; constitutive protein ectodomain proteolysis; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; extracellular matrix disassembly; extracellular matrix organization and biogenesis; in utero embryonic development; integrin-mediated signaling pathway; membrane protein ectodomain proteolysis; monocyte activation; negative regulation of cell adhesion; Notch receptor processing; Notch signaling pathway; PMA-inducible membrane protein ectodomain proteolysis; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; protein amino acid phosphorylation; protein processing

Disease: Alzheimer Disease 18; Reticulate Acropigmentation Of Kitamura
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 Research Articles on ADAM10    1. B cell levels of ADAM10, specifically, are increased in allergic patients and Th2 prone WT mouse strains.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADAM10 antibodyPathways associated with anti-ADAM10 antibody
 Reference Product  PubMed Publications
 APP antibody  >180 publications with ADAM10 and APP
 EGFR antibody  >40 publications with ADAM10 and EGFR
 NOTCH1 antibody  >23 publications with ADAM10 and NOTCH1
 PSEN2 antibody  >6 publications with ADAM10 and PSEN2
 NCSTN antibody  >3 publications with ADAM10 and NCSTN
 NOTCH3 antibody  >3 publications with ADAM10 and NOTCH3
 DLL1 antibody  >3 publications with ADAM10 and DLL1
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies  Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
Diseases associated with anti-ADAM10 antibodyOrgans/Tissues associated with anti-ADAM10 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >242 publications with ADAM10 and Necrosis
 Inflammation Antibodies  >73 publications with ADAM10 and Inflammation
 Skin Diseases Antibodies  >38 publications with ADAM10 and Skin Diseases
 Cardiovascular Diseases Antibodies  >32 publications with ADAM10 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >22 publications with ADAM10 and Kidney Diseases
 Breast Neoplasms Antibodies  >22 publications with ADAM10 and Breast Neoplasms
 Lung Diseases Antibodies  >19 publications with ADAM10 and Lung Diseases
 Liver Diseases Antibodies  >18 publications with ADAM10 and Liver Diseases
 Neoplasms, Experimental Antibodies  >14 publications with ADAM10 and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >14 publications with ADAM10 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >182 publications with ADAM10 and Brain
 Kidney Antibodies  >43 publications with ADAM10 and Kidney
 Embryonic Tissue Antibodies  >38 publications with ADAM10 and Embryonic Tissue
 Lung Antibodies  >30 publications with ADAM10 and Lung
 Bone Antibodies  >29 publications with ADAM10 and Bone
 Liver Antibodies  >27 publications with ADAM10 and Liver
 Skin Antibodies  >26 publications with ADAM10 and Skin
 Intestine Antibodies  >12 publications with ADAM10 and Intestine
 Placenta Antibodies  >9 publications with ADAM10 and Placenta
 Testis Antibodies  >8 publications with ADAM10 and Testis
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