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anti-ADAM17/TACE antibody :: Rabbit anti-Human ADAM17/TACE Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS851568
Unit / Price
0.1 mg  /  $330 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADAM17/TACE, Polyclonal Antibody

★Popular Item★
 Also Known As   

ADAM17/TACE Antibody

 Product Gene Name   

anti-ADAM17/TACE antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603639
 3D Structure    ModBase 3D Structure for P78536
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Purified by peptide affinity column containing 2% BSA and 0.02% NaN3
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 Preparation and Storage    Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C.
 Other Notes    Small volumes of anti-ADAM17/TACE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ADAM17/TACE antibody

   Rabbit polyclonal ADAM17 (1) antibody was raised against a peptide from near the C terminal residues of human ADAM17 protein.
 Product Categories/Family for anti-ADAM17/TACE antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-ADAM17/TACE antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ADAM17/TACE antibody    Peptide ELISA: 1:1,000-1:10,000
WB: 1:200-1,000
IHC: 1:100-500
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 Testing Data of anti-ADAM17/TACE antibody    anti-ADAM17/TACE antibody Testing Data image
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 Testing Data of anti-ADAM17/TACE antibody    anti-ADAM17/TACE antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for ADAM17/TACE. It may not necessarily be applicable to this product.
 NCBI GI #    73747889
 NCBI GeneID    6868
 NCBI Accession #    NP_003174.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_003183.6 [Other Products]
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 UniProt Primary Accession #    P78536 [Other Products]
 UniProt Secondary Accession #    O60226 [Other Products]
 UniProt Related Accession #    P78536 [Other Products]
 Molecular Weight    78,543 Da
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 NCBI Official Full Name    disintegrin and metalloproteinase domain-containing protein 17 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase domain 17
 NCBI Official Symbol    ADAM17 [Similar Products]
 NCBI Official Synonym Symbols   
CSVP; TACE; NISBD; ADAM18; CD156B; NISBD1
[Similar Products]
 NCBI Protein Information    disintegrin and metalloproteinase domain-containing protein 17
 UniProt Protein Name    Disintegrin and metalloproteinase domain-containing protein 17
 UniProt Synonym Protein Names   
Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD_antigen: CD156b
 UniProt Gene Name    ADAM17 [Similar Products]
 UniProt Synonym Gene Names    CSVP; TACE; ADAM 17 [Similar Products]
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 NCBI Summary for ADAM17/TACE    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016]
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 UniProt Comments for ADAM17/TACE    Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
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Product References and Citations for anti-ADAM17/TACE antibody

   (1) Waldhauer, I., Goehlsdorf, D., Gieseke, F., et al.Tumor-associated MICA is shed by ADAM proteases.Cancer Res. 68 (15), 6368-6376 (2008).
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 Research Articles on ADAM17/TACE    1. Plasma levels of ADAM17 are increased in Tanzanian children hospitalized with a malaria infection compared with asymptomatic children but similar to children hospitalized with other infectious diseases. The plasma levels of ADAM17 decreased during recovery after an acute malaria episode.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADAM17/TACE antibodyPathways associated with anti-ADAM17/TACE antibody
 Reference Product  PubMed Publications
 TNF antibody  >112 publications with ADAM17/TACE and TNF
 TIMP3 antibody  >18 publications with ADAM17/TACE and TIMP3
 NOTCH1 antibody  >8 publications with ADAM17/TACE and NOTCH1
 TNFSF11 antibody  >1 publications with ADAM17/TACE and TNFSF11
 TGFA antibody  >1 publications with ADAM17/TACE and TGFA
 DLG1 antibody  >1 publications with ADAM17/TACE and DLG1
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies  Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
Diseases associated with anti-ADAM17/TACE antibodyOrgans/Tissues associated with anti-ADAM17/TACE antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >383 publications with ADAM17/TACE and Necrosis
 Neoplasms Antibodies  >118 publications with ADAM17/TACE and Neoplasms
 Inflammation Antibodies  >85 publications with ADAM17/TACE and Inflammation
 Nervous System Diseases Antibodies  >43 publications with ADAM17/TACE and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >37 publications with ADAM17/TACE and Cardiovascular Diseases
 Liver Diseases Antibodies  >18 publications with ADAM17/TACE and Liver Diseases
 Atherosclerosis Antibodies  >15 publications with ADAM17/TACE and Atherosclerosis
 Lung Diseases Antibodies  >14 publications with ADAM17/TACE and Lung Diseases
 Kidney Diseases Antibodies  >11 publications with ADAM17/TACE and Kidney Diseases
 Liver Neoplasms Antibodies  >11 publications with ADAM17/TACE and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >64 publications with ADAM17/TACE and Brain
 Kidney Antibodies  >32 publications with ADAM17/TACE and Kidney
 Muscle Antibodies  >31 publications with ADAM17/TACE and Muscle
 Liver Antibodies  >31 publications with ADAM17/TACE and Liver
 Lung Antibodies  >30 publications with ADAM17/TACE and Lung
 Embryonic Tissue Antibodies  >26 publications with ADAM17/TACE and Embryonic Tissue
 Ovary Antibodies  >15 publications with ADAM17/TACE and Ovary
 Prostate Antibodies  >10 publications with ADAM17/TACE and Prostate
 Eye Antibodies  >10 publications with ADAM17/TACE and Eye
 Bone Marrow Antibodies  >4 publications with ADAM17/TACE and Bone Marrow
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