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anti-ADAM17/TACE antibody :: Rabbit anti-Human ADAM17/TACE Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS851568
Unit / Price
0.1 mg  /  $330 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADAM17/TACE, Polyclonal Antibody

 Also Known As   

ADAM17/TACE Antibody

 Product Gene Name   

anti-ADAM17/TACE antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 614328
 3D Structure    ModBase 3D Structure for P78536
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Lyophilized anti- ADAM17antibody purified by peptide affinity column containing 2% BSA and 0.02% NaN3
 Concentration    100ug/200ul (lot specific)
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 Source Note    Rabbit polyclonal ADAM17 (1) antibody was raised against a peptide from near the C terminal residues of human ADAM17 protein.
 Reactivity Note    Not yet tested in other species.
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 Preparation and Storage    Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
 Other Notes    Small volumes of anti-ADAM17/TACE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ADAM17/TACE antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-ADAM17/TACE antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ADAM17/TACE antibody    Peptide ELISA titer: 1:1,000-1:10,000
Western blot analysis: 1:200-1,000
Immunohistochemistry: 1:100-500
Optimal dilutions/concentrations should be determined by the end user.
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 Testing Data of anti-ADAM17/TACE antibody    anti-ADAM17/TACE antibody Testing Data image
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 Testing Data #2 of anti-ADAM17/TACE antibody    anti-ADAM17/TACE antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for ADAM17/TACE. It may not necessarily be applicable to this product.
 NCBI GI #    73747889
 NCBI GeneID    6868
 NCBI Accession #    NP_003174.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_003183.4 [Other Products]
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 UniProt Primary Accession #    P78536 [Other Products]
 UniProt Secondary Accession #    O60226 [Other Products]
 UniProt Related Accession #    P78536 [Other Products]
 Molecular Weight    78,543 Da
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 NCBI Official Full Name    disintegrin and metalloproteinase domain-containing protein 17 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase domain 17
 NCBI Official Symbol    ADAM17 [Similar Products]
 NCBI Official Synonym Symbols   
CSVP; TACE; NISBD; ADAM18; CD156B; NISBD1
[Similar Products]
 NCBI Protein Information    disintegrin and metalloproteinase domain-containing protein 17; TNF-alpha convertase; snake venom-like protease; TNF-alpha converting enzyme; ADAM metallopeptidase domain 18; tumor necrosis factor, alpha, converting enzyme
 UniProt Protein Name    Disintegrin and metalloproteinase domain-containing protein 17
 UniProt Synonym Protein Names   
Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD_antigen: CD156b
 UniProt Gene Name    ADAM17 [Similar Products]
 UniProt Synonym Gene Names    CSVP; TACE; ADAM 17 [Similar Products]
 UniProt Entry Name    ADA17_HUMAN
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 NCBI Summary for ADAM17/TACE    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADAM17/TACE    TACE: a type I membrane protein with disintegrin and metalloprotease activity. An ubiquitously expressed ectoenzyme of peptidase family M12B. Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Possesses a narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha) to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, and the amyloid precursor protein. Also involved in the activation of Notch pathway. Binds 1 zinc ion per subunit. Two splice variant isoforms have been described.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; EC 3.4.24.86; Protease

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: cell surface; focal adhesion; membrane; integral to plasma membrane; cytoplasm; apical plasma membrane; plasma membrane; intercellular junction; lipid raft; actin cytoskeleton

Molecular Function: integrin binding; protein binding; interleukin-6 receptor binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; Notch binding; SH3 domain binding; PDZ domain binding

Biological Process: extracellular matrix organization and biogenesis; nerve growth factor receptor signaling pathway; cell motility involved in cell locomotion; T cell differentiation in the thymus; neutrophil mediated immunity; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; proteolysis; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; extracellular matrix disassembly; positive regulation of epidermal growth factor receptor activity; positive regulation of cell proliferation; germinal center formation; negative regulation of interleukin-8 production; cell adhesion; response to drug; spleen development; epidermal growth factor receptor signaling pathway; Notch signaling pathway; response to high density lipoprotein stimulus; membrane protein intracellular domain proteolysis; membrane protein ectodomain proteolysis; positive regulation of transforming growth factor beta receptor signaling pathway; Notch receptor processing; positive regulation of cell motility; positive regulation of cell growth; positive regulation of chemokine production; collagen catabolic process; regulation of mast cell apoptosis; PMA-inducible membrane protein ectodomain proteolysis; B cell differentiation; response to hypoxia; cell adhesion mediated by integrin; positive regulation of protein amino acid phosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway; wound healing, spreading of epidermal cells; positive regulation of cell migration

Disease: Inflammatory Skin And Bowel Disease, Neonatal, 1
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 Research Articles on ADAM17/TACE    1. identified the region in IL-6R that binds to CANDIS. In contrast to the type I transmembrane proteins, the IL-6R, and IL-1RII, CANDIS does not bind the type II transmembrane protein TNF-alpha, demonstrating differences in the respective shedding by ADAM17
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADAM17/TACE antibodyPathways associated with anti-ADAM17/TACE antibody
 Reference Product  PubMed Publications
 EGFR antibody  >134 publications with ADAM17/TACE and EGFR
 ADAM12 antibody  >27 publications with ADAM17/TACE and ADAM12
 TIMP3 antibody  >21 publications with ADAM17/TACE and TIMP3
 NOTCH1 antibody  >13 publications with ADAM17/TACE and NOTCH1
 ERBB2 antibody  >5 publications with ADAM17/TACE and ERBB2
 HBEGF antibody  >1 publications with ADAM17/TACE and HBEGF
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
Diseases associated with anti-ADAM17/TACE antibodyOrgans/Tissues associated with anti-ADAM17/TACE antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >499 publications with ADAM17/TACE and Necrosis
 Inflammation Antibodies  >111 publications with ADAM17/TACE and Inflammation
 Nervous System Diseases Antibodies  >54 publications with ADAM17/TACE and Nervous System Diseases
 Brain Diseases Antibodies  >46 publications with ADAM17/TACE and Brain Diseases
 Disease Models, Animal Antibodies  >30 publications with ADAM17/TACE and Disease Models, Animal
 Liver Diseases Antibodies  >23 publications with ADAM17/TACE and Liver Diseases
 Breast Neoplasms Antibodies  >23 publications with ADAM17/TACE and Breast Neoplasms
 Atherosclerosis Antibodies  >21 publications with ADAM17/TACE and Atherosclerosis
 Kidney Diseases Antibodies  >19 publications with ADAM17/TACE and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >16 publications with ADAM17/TACE and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >79 publications with ADAM17/TACE and Brain
 Kidney Antibodies  >44 publications with ADAM17/TACE and Kidney
 Liver Antibodies  >40 publications with ADAM17/TACE and Liver
 Lung Antibodies  >39 publications with ADAM17/TACE and Lung
 Muscle Antibodies  >37 publications with ADAM17/TACE and Muscle
 Embryonic Tissue Antibodies  >31 publications with ADAM17/TACE and Embryonic Tissue
 Ovary Antibodies  >17 publications with ADAM17/TACE and Ovary
 Prostate Antibodies  >12 publications with ADAM17/TACE and Prostate
 Eye Antibodies  >10 publications with ADAM17/TACE and Eye
 Bone Marrow Antibodies  >8 publications with ADAM17/TACE and Bone Marrow
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