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anti-ADAM8 antibody :: Rabbit anti-Human ADAM8 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242896
Unit / Price
0.05 mL  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADAM8, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human ADAM8

 Product Synonym Names    Anti-ADAM8 Antibody IHC-plus; ADAM metallopeptidase domain 8; Cell surface antigen MS2; ADAM 8; MS2; CD156; CD156a antigen; Human ADAM8
 Product Gene Name   

anti-ADAM8 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602267
 3D Structure    ModBase 3D Structure for P78325
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Human ADAM8.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, pH 7, 1% BSA, 20% Glycerol, 0.01% Thimerosal
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide containing a sequence corresponding to a region within amino acids 763 and 824 of Human CD156.
 Immunogen Type    Synthetic peptide
 Immunogen    ADAM8 antibody was raised against synthetic peptide containing a sequence corresponding to a region within amino acids 763 and 824 of Human CD156.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 Other Notes    Small volumes of anti-ADAM8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ADAM8 antibody

   ADAM8 is a Metallopeptidase M12B type protease.
 Product Categories/Family for anti-ADAM8 antibody    Family: Protease
Subfamily: Metallopeptidase M12B
 Applications Tested/Suitable for anti-ADAM8 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-ADAM8 antibody    IHC-P (20 ug/ml), WB (1:500 - 1:3000)
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 Immunohistochemistry (IHC) of anti-ADAM8 antibody    Anti-ADAM8 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
anti-ADAM8 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ADAM8 antibody    Anti-ADAM8 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
anti-ADAM8 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ADAM8 antibody    Anti-ADAM8 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
anti-ADAM8 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-ADAM8 antibody    Sample(30 g of whole cell lysate). A: Raji. 7.5% SDS PAGE. ADAM8 antibody diluted at 1:500.
anti-ADAM8 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ADAM8. It may not necessarily be applicable to this product.
 NCBI GI #    256773264
 NCBI GeneID    101
 NCBI Accession #    NP_001100.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001109.4 [Other Products]
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 UniProt Primary Accession #    P78325 [Other Products]
 UniProt Secondary Accession #    B4DVM6; H0YL36; H0YLR0; H0YN39 [Other Products]
 UniProt Related Accession #    P78325 [Other Products]
 Molecular Weight    80,262 Da
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 NCBI Official Full Name    disintegrin and metalloproteinase domain-containing protein 8 isoform 1
 NCBI Official Synonym Full Names    ADAM metallopeptidase domain 8
 NCBI Official Symbol    ADAM8 [Similar Products]
 NCBI Official Synonym Symbols   
MS2; CD156; CD156a
[Similar Products]
 NCBI Protein Information    disintegrin and metalloproteinase domain-containing protein 8; cell surface antigen MS2; human leukocyte differentiation antigen; a disintegrin and metalloproteinase domain 8
 UniProt Protein Name    Disintegrin and metalloproteinase domain-containing protein 8
 UniProt Synonym Protein Names   
Cell surface antigen MS2; CD_antigen: CD156a
 Protein Family    Disintegrin and metalloproteinase domain-containing protein
 UniProt Gene Name    ADAM8 [Similar Products]
 UniProt Synonym Gene Names    MS2; ADAM 8 [Similar Products]
 UniProt Entry Name    ADAM8_HUMAN
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 NCBI Summary for ADAM8    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]
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 UniProt Comments for ADAM8    ADAM8: Possible involvement in extravasation of leukocytes.

Protein type: Membrane protein, integral; Protease; Motility/polarity/chemotaxis; EC 3.4.24.-

Chromosomal Location of Human Ortholog: 10q26.3

Cellular Component: specific granule; cell surface; integral to plasma membrane; cytoplasm; plasma membrane; podosome; dense core granule membrane

Molecular Function: protein binding; protein self-association; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity; calcium ion binding; cell adhesion molecule binding

Biological Process: extracellular matrix organization and biogenesis; positive regulation of cell adhesion; cell morphogenesis; proteolysis; positive regulation of membrane protein ectodomain proteolysis; leukocyte migration during inflammatory response; activation of NF-kappaB transcription factor; positive regulation of T cell differentiation in the thymus; positive regulation of protein kinase B signaling cascade; extracellular matrix disassembly; cell-cell adhesion; regulation of cell-cell adhesion; positive regulation of protein secretion; positive regulation of acute inflammatory response; positive regulation of bone resorption; negative regulation of neuron apoptosis; angiogenesis; inflammatory response; lymphocyte chemotaxis
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 Research Articles on ADAM8    1. ADAM8 expression is increased in both severe asthma and COPD and associated with sputum total cell count and neutrophils. ADAM8 may facilitate neutrophil migration to the airways in severe asthma and COPD.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ADAM8 antibodyDiseases associated with anti-ADAM8 antibody
 Products by Pathway  Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >39 publications with ADAM8 and Inflammation
 Lung Diseases Antibodies  >21 publications with ADAM8 and Lung Diseases
 Necrosis Antibodies  >18 publications with ADAM8 and Necrosis
 Disease Models, Animal Antibodies  >13 publications with ADAM8 and Disease Models, Animal
 Brain Diseases Antibodies  >8 publications with ADAM8 and Brain Diseases
 Cardiovascular Diseases Antibodies  >8 publications with ADAM8 and Cardiovascular Diseases
 Liver Diseases Antibodies  >7 publications with ADAM8 and Liver Diseases
 Carcinoma, Squamous Cell Antibodies  >6 publications with ADAM8 and Carcinoma, Squamous Cell
 Lung Neoplasms Antibodies  >6 publications with ADAM8 and Lung Neoplasms
 Fibrosis Antibodies  >6 publications with ADAM8 and Fibrosis
Organs/Tissues associated with anti-ADAM8 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >45 publications with ADAM8 and Blood
 Lung Antibodies  >23 publications with ADAM8 and Lung
 Brain Antibodies  >16 publications with ADAM8 and Brain
 Connective Tissue Antibodies  >7 publications with ADAM8 and Connective Tissue
 Kidney Antibodies  >6 publications with ADAM8 and Kidney
 Bone Marrow Antibodies  >6 publications with ADAM8 and Bone Marrow
 Stomach Antibodies  >5 publications with ADAM8 and Stomach
 Eye Antibodies  >2 publications with ADAM8 and Eye
 Spleen Antibodies  >2 publications with ADAM8 and Spleen
 Prostate Antibodies  >2 publications with ADAM8 and Prostate
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