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anti-ADAMTS1 antibody :: Goat anti-Human ADAMTS1 Propeptide 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS621940 anti-ADAMTS1 antibody
Unit / Price
0.1 mg  /  $710 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADAMTS1 Propeptide 1, Polyclonal Antibody

 Also Known As   

ADAMTS1 Propeptide 1 (A Disintegrin And Metalloproteinase with ThromboSpondin-1 motif, METH-1)

 Product Synonym Names    Anti -ADAMTS1 Propeptide 1 (A Disintegrin And Metalloproteinase with ThromboSpondin-1 motif, METH-1)
 Product Gene Name   

anti-ADAMTS1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 21; NC_000021.8 (28208606..28217728, complement). Location: 21q21.2
 3D Structure    ModBase 3D Structure for Q5HYL0
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Goat
 Species Reactivity    Human
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 Specificity    Recognizes human ADAMTS1 Propeptide.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a lyophilized powder in 0.2um sterile-filtered solution in PBS with 5% trehalose. Reconstitute with 40-50% glycerol, PBS.
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 Immunogen    NS0-derived, recombinat human ADAMTS1 Propeptide; aa50-252.
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 Preparation and Storage    Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-ADAMTS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ADAMTS1 antibody    Antibodies; Abs to Matrix Metalloproteinases
 Applications Tested/Suitable for anti-ADAMTS1 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

 Application Notes for anti-ADAMTS1 antibody    Suitable for use in ELISA, Western Blot, and Immunoprecipitation.
Dilution: ELISA: 0.5-1.0ug/ml
Western Blot: 0.1-0.2ug/ml
Immunoprecipitation: 15ug/ml
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NCBI/Uniprot data below describe general gene information for ADAMTS1. It may not necessarily be applicable to this product.
 NCBI GI #    50845384
 NCBI GeneID    9510
 NCBI Accession #    NP_008919.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_006988.3 [Other Products]
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 UniProt Primary Accession #    Q5HYL0 [Other Products]
 UniProt Related Accession #    Q5HYL0; Q6ZP79; Q8NE26; Q9UHI8 [Other Products]
 Molecular Weight    105,354 Da [Similar Products]
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 NCBI Official Full Name    A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase with thrombospondin type 1 motif, 1
 NCBI Official Symbol    ADAMTS1 [Similar Products]
 NCBI Official Synonym Symbols   
C3-C5; METH1; KIAA1346
[Similar Products]
 NCBI Protein Information    A disintegrin and metalloproteinase with thrombospondin motifs 1; METH-1; ADAM-TS1; ADAMTS-1; ADAM-TS 1; OTTHUMP00000096354; human metalloproteinase with thrombospondin type 1 motifs; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1
 UniProt Protein Name    Putative uncharacterized protein DKFZp686E01144
 Protein Family    A disintegrin and metalloproteinase with thrombospondin motifs
 UniProt Gene Name    DKFZp686E01144 [Similar Products]
 UniProt Entry Name    Q5HYL0_HUMAN
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 NCBI Summary for ADAMTS1    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq]
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 UniProt Comments for ADAMTS1    ADAMTS1: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.

Protein type: Secreted; Protease; Motility/polarity/chemotaxis; EC 3.4.24.-; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 21q21.2

Cellular Component: cytoplasm; basement membrane; cytoplasmic vesicle

Molecular Function: heparin binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity

Biological Process: integrin-mediated signaling pathway; negative regulation of cell proliferation; ovulation from ovarian follicle; kidney development; proteolysis
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 Research Articles on ADAMTS1    1. AHR, a novel acute hypoxia-response sequence, drives reporter gene expression under hypoxia in vitro and in vivo.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADAMTS1 antibodyPathways associated with anti-ADAMTS1 antibody
 Reference Product  PubMed Publications
 FURIN antibody  >8 publications with ADAMTS1 and FURIN
 VCAN antibody  >5 publications with ADAMTS1 and VCAN
 VEGFA antibody  >3 publications with ADAMTS1 and VEGFA
 ACAN antibody  >2 publications with ADAMTS1 and ACAN
 Products by Pathway  Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
Diseases associated with anti-ADAMTS1 antibodyOrgans/Tissues associated with anti-ADAMTS1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >50 publications with ADAMTS1 and Neoplasms
 Cardiovascular Diseases Antibodies  >22 publications with ADAMTS1 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >21 publications with ADAMTS1 and Vascular Diseases
 Metaplasia Antibodies  >17 publications with ADAMTS1 and Metaplasia
 Neovascularization, Pathologic Antibodies  >16 publications with ADAMTS1 and Neovascularization, Pathologic
 Carcinoma Antibodies  >15 publications with ADAMTS1 and Carcinoma
 Inflammation Antibodies  >14 publications with ADAMTS1 and Inflammation
 Osteoarthritis Antibodies  >12 publications with ADAMTS1 and Osteoarthritis
 Neoplasm Metastasis Antibodies  >10 publications with ADAMTS1 and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >10 publications with ADAMTS1 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >48 publications with ADAMTS1 and Vascular
 Ovary Antibodies  >24 publications with ADAMTS1 and Ovary
 Bone Antibodies  >20 publications with ADAMTS1 and Bone
 Kidney Antibodies  >19 publications with ADAMTS1 and Kidney
 Heart Antibodies  >18 publications with ADAMTS1 and Heart
 Connective Tissue Antibodies  >18 publications with ADAMTS1 and Connective Tissue
 Muscle Antibodies  >18 publications with ADAMTS1 and Muscle
 Embryonic Tissue Antibodies  >12 publications with ADAMTS1 and Embryonic Tissue
 Brain Antibodies  >12 publications with ADAMTS1 and Brain
 Lung Antibodies  >10 publications with ADAMTS1 and Lung
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