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anti-ADAMTS1 antibody :: Rabbit ADAMTS1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241501
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADAMTS1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Polyclonal to Human ADAMTS1

 Product Synonym Names    Anti-ADAMTS1 Antibody (Internal) IHC-plus; ADAM-TS; ADAMTS-1; ADAM-TS 1; C3-C5; ADAM-TS1; METH-1; METH1; KIAA1346; Human ADAMTS1
 Product Gene Name   

anti-ADAMTS1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605174
 3D Structure    ModBase 3D Structure for Q9UHI8
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Gibbon, Gorilla, Human, Monkey, Orangutan
Predicted Reactivity: Horse (at least 90% immunogen sequence identity)
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 Specificity    Human ADAMTS1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic 17 amino acid peptide from internal region of human ADAMTS1. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset (100%); Elephant, Horse (94%); Bat, Pig (88%).
 Immunogen Type    Synthetic peptide
 Immunogen    ADAMTS1 antibody was raised against synthetic 17 amino acid peptide from internal region of human ADAMTS1. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset (100%); Elephant, Horse (94%); Bat, Pig (88%); Mouse, Rat, Hamster, Rabbit (82%).
 Antigen Modification    Internal
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 Preparation and Storage    Store at 4 degree C for short term applications. For long term storage, aliquot and store at -20 degree C.
 Other Notes    Small volumes of anti-ADAMTS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ADAMTS1 antibody

   ADAMTS1 is a Metallopeptidase M12B type protease.
 Product Categories/Family for anti-ADAMTS1 antibody    Family: Protease
Subfamily: Metallopeptidase M12B
 Applications Tested/Suitable for anti-ADAMTS1 antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-ADAMTS1 antibody    IHC-P (20 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-ADAMTS1 antibody    Anti-ADAMTS1 antibody IHC of human testis, vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-ADAMTS1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ADAMTS1. It may not necessarily be applicable to this product.
 NCBI GI #    50845384
 NCBI GeneID    9510
 NCBI Accession #    NP_008919.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_006988.4 [Other Products]
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 UniProt Primary Accession #    Q9UHI8 [Other Products]
 UniProt Secondary Accession #    Q9NSJ8; Q9P2K0; Q9UH83; Q9UP80; D3DSD5 [Other Products]
 UniProt Related Accession #    Q9UHI8 [Other Products]
 Molecular Weight    105,358 Da
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 NCBI Official Full Name    A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase with thrombospondin type 1 motif, 1
 NCBI Official Symbol    ADAMTS1 [Similar Products]
 NCBI Official Synonym Symbols   
C3-C5; METH1
[Similar Products]
 NCBI Protein Information    A disintegrin and metalloproteinase with thrombospondin motifs 1; METH-1; ADAM-TS1; ADAMTS-1; ADAM-TS 1; human metalloproteinase with thrombospondin type 1 motifs; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1
 UniProt Protein Name    A disintegrin and metalloproteinase with thrombospondin motifs 1
 UniProt Synonym Protein Names   
METH-1
 Protein Family    A disintegrin and metalloproteinase with thrombospondin motifs
 UniProt Gene Name    ADAMTS1 [Similar Products]
 UniProt Synonym Gene Names    KIAA1346; METH1; ADAM-TS 1; ADAM-TS1; ADAMTS-1 [Similar Products]
 UniProt Entry Name    ATS1_HUMAN
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 NCBI Summary for ADAMTS1    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADAMTS1    ADAMTS1: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.

Protein type: EC 3.4.24.-; Secreted; Motility/polarity/chemotaxis; Protease; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 21q21.2

Cellular Component: cytoplasm; basement membrane; cytoplasmic vesicle

Molecular Function: heparin binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity

Biological Process: integrin-mediated signaling pathway; negative regulation of cell proliferation; proteolysis; kidney development; ovulation from ovarian follicle
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 Research Articles on ADAMTS1    1. Dysregulated expression of ADAMTS-1 in polycystic ovary syndrome may influence oocyte quality-via Granulosa cells-oocyte paracrine and endocrine mechanism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADAMTS1 antibodyPathways associated with anti-ADAMTS1 antibody
 Reference Product  PubMed Publications
 FURIN antibody  >9 publications with ADAMTS1 and FURIN
 VCAN antibody  >7 publications with ADAMTS1 and VCAN
 VEGFA antibody  >7 publications with ADAMTS1 and VEGFA
 FGF2 antibody  >4 publications with ADAMTS1 and FGF2
 ACAN antibody  >2 publications with ADAMTS1 and ACAN
 Products by Pathway  Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 O-glycosylation Of TSR Domain-containing Proteins Pathway antibodies  O-glycosylation Of TSR Domain-containing Proteins Pathway Diagram
 O-linked Glycosylation Pathway antibodies  O-linked Glycosylation Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
Diseases associated with anti-ADAMTS1 antibodyOrgans/Tissues associated with anti-ADAMTS1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >21 publications with ADAMTS1 and Inflammation
 Necrosis Antibodies  >16 publications with ADAMTS1 and Necrosis
 Neoplasms, Experimental Antibodies  >14 publications with ADAMTS1 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >13 publications with ADAMTS1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >12 publications with ADAMTS1 and Adenocarcinoma
 Kidney Diseases Antibodies  >11 publications with ADAMTS1 and Kidney Diseases
 Heart Diseases Antibodies  >11 publications with ADAMTS1 and Heart Diseases
 Fibrosis Antibodies  >9 publications with ADAMTS1 and Fibrosis
 Brain Diseases Antibodies  >9 publications with ADAMTS1 and Brain Diseases
 Lung Neoplasms Antibodies  >7 publications with ADAMTS1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >69 publications with ADAMTS1 and Vascular
 Ovary Antibodies  >38 publications with ADAMTS1 and Ovary
 Bone Antibodies  >28 publications with ADAMTS1 and Bone
 Connective Tissue Antibodies  >25 publications with ADAMTS1 and Connective Tissue
 Muscle Antibodies  >25 publications with ADAMTS1 and Muscle
 Heart Antibodies  >23 publications with ADAMTS1 and Heart
 Kidney Antibodies  >23 publications with ADAMTS1 and Kidney
 Brain Antibodies  >19 publications with ADAMTS1 and Brain
 Embryonic Tissue Antibodies  >18 publications with ADAMTS1 and Embryonic Tissue
 Lung Antibodies  >11 publications with ADAMTS1 and Lung
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