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anti-ADAMTS18 antibody :: Rabbit anti-Human, Mouse ADAMTS18 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2521398
Western Blot (WB)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADAMTS18, Polyclonal Antibody

★Popular Item★
 Also Known As   

ADAMTS18 Polyclonal Antibody

 Product Synonym Names    KNO2; MMCAT; ADAMTS21
 Product Gene Name   

anti-ADAMTS18 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607512
 3D Structure    ModBase 3D Structure for Q8TE60
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Affinity purification
 Concentration    0.3mg/mL (lot specific)
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 Immunogen    Synthetic peptide of human ADAMTS18
 Calculated Molecular Weight    135kDa
 Observed molecular weight    refer to figures
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20C. Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-ADAMTS18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ADAMTS18 antibody

   This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.
 Product Categories/Family for anti-ADAMTS18 antibody    Cell biology; Epigenetics
 Applications Tested/Suitable for anti-ADAMTS18 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-ADAMTS18 antibody    WB: 1:200-1:1000
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 Western Blot (WB) of anti-ADAMTS18 antibody    Western blot analysis of Human prostate tissue, using ADAMTS18 Polyclonal Antibody at dilution of 1:250
anti-ADAMTS18 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ADAMTS18. It may not necessarily be applicable to this product.
 NCBI GI #    40806187
 NCBI GeneID    170692
 NCBI Accession #    NP_955387 [Other Products]
 NCBI GenBank Nucleotide #    NM_199355.2 [Other Products]
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 UniProt Primary Accession #    Q8TE60 [Other Products]
 UniProt Secondary Accession #    Q6P4R5; Q6ZWJ9 [Other Products]
 UniProt Related Accession #    Q8TE60 [Other Products]
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 NCBI Official Full Name    A disintegrin and metalloproteinase with thrombospondin motifs 18 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase with thrombospondin type 1 motif, 18
 NCBI Official Symbol    ADAMTS18 [Similar Products]
 NCBI Official Synonym Symbols   
KNO2; MMCAT; ADAMTS21
[Similar Products]
 NCBI Protein Information    A disintegrin and metalloproteinase with thrombospondin motifs 18; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 21; disintegrin and metalloprotease-like protein
 UniProt Protein Name    A disintegrin and metalloproteinase with thrombospondin motifs 18
 Protein Family    A disintegrin and metalloproteinase with thrombospondin motifs
 UniProt Gene Name    ADAMTS18 [Similar Products]
 UniProt Synonym Gene Names    ADAMTS21; ADAM-TS 18; ADAM-TS18; ADAMTS-18 [Similar Products]
 UniProt Entry Name    ATS18_HUMAN
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 NCBI Summary for ADAMTS18    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADAMTS18    ADAMTS18: Defects in ADAMTS18 are the cause of Knobloch syndrome type 2 (KNO2). A developmental disorder primarily characterized by typical eye abnormalities, including high myopia, cataracts, dislocated lens, vitreoretinal degeneration, and retinal detachment, with occipital skull defects, which can range from occipital encephalocele to occult cutis aplasia. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; EC 3.4.24.-; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 16q23

Cellular Component: proteinaceous extracellular matrix

Molecular Function: zinc ion binding; metalloendopeptidase activity

Biological Process: eye development; proteolysis

Disease: Microcornea, Myopic Chorioretinal Atrophy, And Telecanthus
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 Research Articles on ADAMTS18    1. Novel homozygous mutations in ADAMTS18 were identified, consisting of c.1067T>A [p.L356*] in the first proband, c.2159G>C [p.C720S] in the 2 affected brothers
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADAMTS18 antibodyPathways associated with anti-ADAMTS18 antibody
 Reference Product  PubMed Publications
 CATSPERB antibody  >1 publications with ADAMTS18 and CATSPERB
 TGFBR3 antibody  >1 publications with ADAMTS18 and TGFBR3
 Products by Pathway  Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 O-glycosylation Of TSR Domain-containing Proteins Pathway antibodies  O-glycosylation Of TSR Domain-containing Proteins Pathway Diagram
 O-linked Glycosylation Pathway antibodies  O-linked Glycosylation Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
Diseases associated with anti-ADAMTS18 antibodyOrgans/Tissues associated with anti-ADAMTS18 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with ADAMTS18 and Nervous System Diseases
 Nervous System Malformations Antibodies  >3 publications with ADAMTS18 and Nervous System Malformations
 Atrophy Antibodies  >2 publications with ADAMTS18 and Atrophy
 Neoplasm Metastasis Antibodies  >2 publications with ADAMTS18 and Neoplasm Metastasis
 Inflammation Antibodies  >2 publications with ADAMTS18 and Inflammation
 Musculoskeletal Abnormalities Antibodies  >1 publications with ADAMTS18 and Musculoskeletal Abnormalities
 Brain Diseases Antibodies  >1 publications with ADAMTS18 and Brain Diseases
 Craniofacial Abnormalities Antibodies  >1 publications with ADAMTS18 and Craniofacial Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >6 publications with ADAMTS18 and Eye
 Lung Antibodies  >3 publications with ADAMTS18 and Lung
 Vascular Antibodies  >2 publications with ADAMTS18 and Vascular
 Brain Antibodies  >2 publications with ADAMTS18 and Brain
 Embryonic Tissue Antibodies  >1 publications with ADAMTS18 and Embryonic Tissue
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