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anti-ADAMTS18 antibody :: Rabbit ADAMTS18 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS854348
Unit / Price
0.1 mg  /  $330 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADAMTS18, Polyclonal Antibody

 Also Known As   

ADAMTS18 Antibody

 Product Gene Name   

anti-ADAMTS18 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607512
 3D Structure    ModBase 3D Structure for Q8TE60
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
Predicted: Mouse, Rat
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 Form/Format    Purified by protein A column containing 0.02% NaN3
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 Preparation and Storage    Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
 Other Notes    Small volumes of anti-ADAMTS18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ADAMTS18 antibody

   Rabbit polyclonal ADAMTS18(1) antibody was raised against a recombinate human ADAMTS18 protein 712-970aa (BC063283).
 Product Categories/Family for anti-ADAMTS18 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-ADAMTS18 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ADAMTS18 antibody    ELISA: 1:20,000-1:80,000
WB: 1:500-1:1,000
IHC: 1:100-1:500
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 Testing Data of anti-ADAMTS18 antibody    anti-ADAMTS18 antibody Testing Data image
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 Testing Data of anti-ADAMTS18 antibody    anti-ADAMTS18 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for ADAMTS18. It may not necessarily be applicable to this product.
 NCBI GI #    40806187
 NCBI GeneID    170692
 NCBI Accession #    NP_955387.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_199355.3 [Other Products]
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 UniProt Primary Accession #    Q8TE60 [Other Products]
 UniProt Secondary Accession #    Q6P4R5; Q6ZWJ9 [Other Products]
 UniProt Related Accession #    Q8TE60 [Other Products]
 Molecular Weight    119,768 Da
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 NCBI Official Full Name    A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform 1 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase with thrombospondin type 1 motif 18
 NCBI Official Symbol    ADAMTS18 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    A disintegrin and metalloproteinase with thrombospondin motifs 18
 UniProt Protein Name    A disintegrin and metalloproteinase with thrombospondin motifs 18
 Protein Family    A disintegrin and metalloproteinase with thrombospondin motifs
 UniProt Gene Name    ADAMTS18 [Similar Products]
 UniProt Synonym Gene Names    ADAMTS21; ADAM-TS 18; ADAM-TS18; ADAMTS-18 [Similar Products]
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 NCBI Summary for ADAMTS18    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may regulate hemostatic balance and function as a tumor suppressor. Mutations in this gene may be associated with microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) and cone-rod dystrophy in human patients. [provided by RefSeq, May 2016]
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 UniProt Comments for ADAMTS18    CautionVariant Leu-179 has been originally reported as disease-causing mutation in a patient with Knobloch syndrome (PubMed:21862674). It has been subsequently shown that Knobloch syndrome in the patient was due to an intronic mutation in COL18A1. Variant Leu-179 is, therefore, not responsible for the disease phenotype (PubMed:23667181).
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Product References and Citations for anti-ADAMTS18 antibody

   (1) Wei, X., Prickett, T.D., Viloria, C.G., et al. Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma. Mol. Cancer Res. 8 (11), 1513-1525 (2010).
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 Research Articles on ADAMTS18    1. In summary, we demonstrate that ADAMTS18 silencing in breast cancer is significantly correlated with promoter CpG methylation. ADAMTS18 acts as an antagonist of AKT and NF-kappaB signaling, further suppressing EMT and metastasis of breast cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-ADAMTS18 antibodyOrgans/Tissues associated with anti-ADAMTS18 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5 publications with ADAMTS18 and Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with ADAMTS18 and Neoplasm Metastasis
 Nervous System Malformations Antibodies  >2 publications with ADAMTS18 and Nervous System Malformations
 Neoplasm Invasiveness Antibodies  >1 publications with ADAMTS18 and Neoplasm Invasiveness
 Atrophy Antibodies  >1 publications with ADAMTS18 and Atrophy
 Brain Diseases Antibodies  >1 publications with ADAMTS18 and Brain Diseases
 Inflammation Antibodies  >1 publications with ADAMTS18 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >3 publications with ADAMTS18 and Eye
 Lung Antibodies  >3 publications with ADAMTS18 and Lung
 Vascular Antibodies  >2 publications with ADAMTS18 and Vascular
 Brain Antibodies  >2 publications with ADAMTS18 and Brain
 Embryonic Tissue Antibodies  >1 publications with ADAMTS18 and Embryonic Tissue
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