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anti-ADAMTS5 antibody :: Rabbit ADAMTS5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS243899
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADAMTS5, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human ADAMTS5

 Product Synonym Names    Anti-ADAMTS5 Antibody (Internal) IHC-plus; ADAMTS5; Aggrecanase-2; ADAM-TS 11; ADAM-TS5; ADAMTS-11; ADAMTS11; ADAM-TS 5; ADAMTS-5; ADMP-2; ADMP2; Human ADAMTS5
 Product Gene Name   

anti-ADAMTS5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605007
 3D Structure    ModBase 3D Structure for Q9UNA0
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Gibbon, Gorilla, Human, Monkey
Predicted Reactivity: Rat, Bat, Bovine, Dog, Hamster, Pig, Rabbit (at least 90% immunogen sequence identity)
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 Specificity    Human ADAMTS5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic 16 amino acid peptide from internal region of human ADAMTS5. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Rat, Dog, Bat, Bovine, Hamster, Elephant, Panda, Rabbit, Pig (94%).
 Immunogen Type    Synthetic peptide
 Immunogen    ADAMTS5 antibody was raised against synthetic 16 amino acid peptide from internal region of human ADAMTS5. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Rat, Dog, Bat, Bovine, Hamster, Elephant, Panda, Rabbit, Pig (94%); Mouse, Horse, Turkey, Lizard, Xenopus (88%).
 Antigen Modification    Internal
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 Preparation and Storage    Store at 4 degree C for short term applications. For long term storage, aliquot and store at -20 degree C.
 Other Notes    Small volumes of anti-ADAMTS5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ADAMTS5 antibody

   ADAMTS5, also known as aggrecanase-2, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan. The protein contains a signal sequence, a prodomain with both a potential cysteine switch and a furin cleavage site, a metalloproteinase domain with a conserved zinc-binding motif and a 'met turn,' a disintegrin-like domain, and a spacer region between a thrombospondin type 1 motif and thrombospondin submotif.
 Product Categories/Family for anti-ADAMTS5 antibody    Family: Protease
Subfamily: Metallopeptidase M12B
 Applications Tested/Suitable for anti-ADAMTS5 antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-ADAMTS5 antibody    IHC-P (20 ug/ml)
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 Immunohistochemistry (IHC) of anti-ADAMTS5 antibody    Anti-ADAMTS5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-ADAMTS5 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ADAMTS5. It may not necessarily be applicable to this product.
 NCBI GI #    195539372
 NCBI GeneID    11096
 NCBI Accession #    NP_008969.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_007038.3 [Other Products]
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 UniProt Primary Accession #    Q9UNA0 [Other Products]
 UniProt Secondary Accession #    Q52LV4; Q9UKP2 [Other Products]
 UniProt Related Accession #    Q9UNA0 [Other Products]
 Molecular Weight    101,718 Da
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 NCBI Official Full Name    A disintegrin and metalloproteinase with thrombospondin motifs 5 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase with thrombospondin type 1 motif, 5
 NCBI Official Symbol    ADAMTS5 [Similar Products]
 NCBI Official Synonym Symbols   
ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11
[Similar Products]
 NCBI Protein Information    A disintegrin and metalloproteinase with thrombospondin motifs 5; aggrecanase-2; a disintegrin and metalloproteinase with thrombospondin motifs 11; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
 UniProt Protein Name    A disintegrin and metalloproteinase with thrombospondin motifs 5
 UniProt Synonym Protein Names   
A disintegrin and metalloproteinase with thrombospondin motifs 11; ADAM-TS 11; ADAMTS-11; ADMP-2; Aggrecanase-2
 Protein Family    A disintegrin and metalloproteinase with thrombospondin motifs
 UniProt Gene Name    ADAMTS5 [Similar Products]
 UniProt Synonym Gene Names    ADAMTS11; ADMP2; ADAM-TS 5; ADAM-TS5; ADAMTS-5; ADAM-TS 11; ADAMTS-11 [Similar Products]
 UniProt Entry Name    ATS5_HUMAN
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 NCBI Summary for ADAMTS5    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADAMTS5    ADAMTS5: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide; Protease; Extracellular matrix; EC 3.4.24.-

Chromosomal Location of Human Ortholog: 21q21.3

Cellular Component: proteinaceous extracellular matrix; endoplasmic reticulum lumen; extracellular region

Molecular Function: integrin binding; protein binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity

Biological Process: extracellular matrix disassembly; protein amino acid O-linked glycosylation; extracellular matrix organization and biogenesis; cellular protein metabolic process; defense response to bacterium; proteolysis; post-translational protein modification
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 Research Articles on ADAMTS5    1. The present study reveals ADAMT-5 expression by mast cells(MCs) and that MC activation regulates the expression of the protease, thus implicating the ADAMT-5 of protease in MC function.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADAMTS5 antibodyPathways associated with anti-ADAMTS5 antibody
 Reference Product  PubMed Publications
 MMP13 antibody  >41 publications with ADAMTS5 and MMP13
 MMP3 antibody  >19 publications with ADAMTS5 and MMP3
 TIMP3 antibody  >15 publications with ADAMTS5 and TIMP3
 ACAN antibody  >14 publications with ADAMTS5 and ACAN
 FGF2 antibody  >9 publications with ADAMTS5 and FGF2
 RUNX2 antibody  >9 publications with ADAMTS5 and RUNX2
 FURIN antibody  >4 publications with ADAMTS5 and FURIN
 SDC4 antibody  >4 publications with ADAMTS5 and SDC4
 Products by Pathway  Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 O-glycosylation Of TSR Domain-containing Proteins Pathway antibodies  O-glycosylation Of TSR Domain-containing Proteins Pathway Diagram
 O-linked Glycosylation Pathway antibodies  O-linked Glycosylation Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
Diseases associated with anti-ADAMTS5 antibodyOrgans/Tissues associated with anti-ADAMTS5 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >43 publications with ADAMTS5 and Disease Models, Animal
 Necrosis Antibodies  >36 publications with ADAMTS5 and Necrosis
 Inflammation Antibodies  >26 publications with ADAMTS5 and Inflammation
 Nervous System Diseases Antibodies  >12 publications with ADAMTS5 and Nervous System Diseases
 Hypertrophy Antibodies  >9 publications with ADAMTS5 and Hypertrophy
 Central Nervous System Diseases Antibodies  >5 publications with ADAMTS5 and Central Nervous System Diseases
 Fibrosis Antibodies  >4 publications with ADAMTS5 and Fibrosis
 Brain Diseases Antibodies  >4 publications with ADAMTS5 and Brain Diseases
 Hyperplasia Antibodies  >3 publications with ADAMTS5 and Hyperplasia
 Weight Loss Antibodies  >3 publications with ADAMTS5 and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >52 publications with ADAMTS5 and Connective Tissue
 Muscle Antibodies  >14 publications with ADAMTS5 and Muscle
 Embryonic Tissue Antibodies  >13 publications with ADAMTS5 and Embryonic Tissue
 Brain Antibodies  >11 publications with ADAMTS5 and Brain
 Skin Antibodies  >6 publications with ADAMTS5 and Skin
 Liver Antibodies  >4 publications with ADAMTS5 and Liver
 Heart Antibodies  >4 publications with ADAMTS5 and Heart
 Eye Antibodies  >4 publications with ADAMTS5 and Eye
 Placenta Antibodies  >3 publications with ADAMTS5 and Placenta
 Lung Antibodies  >2 publications with ADAMTS5 and Lung
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