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anti-ADAMTSL4 antibody :: Mouse anti-Human ADAMTSL4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS649757 anti-ADAMTSL4 antibody
Unit / Price
0.05 mg  /  $580 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADAMTSL4, Polyclonal Antibody

 Also Known As   

ADAMTSL4 (ADAMTS-like Protein 4, ADAMTSL-4, Thrombospondin Repeat-containing Protein 1, TSRC1, PP1396, UNQ2803/PRO34012, DKFZP434K1772)

 Product Synonym Names    Anti -ADAMTSL4 (ADAMTS-like Protein 4, ADAMTSL-4, Thrombospondin Repeat-containing Protein 1, TSRC1, PP1396, UNQ2803/PRO34012, DKFZP434K1772)
 Product Gene Name   

anti-ADAMTSL4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    MPAPPHPRTP LGSPAAYWKR VGHSACSASC GKGVWRPIFL CISRESGEEL DERSCAAGAR PPASPEPCHG TPCPPYWEAG EWTSCSRSCG PGTQHRQLQC RQEFGGGGSS VPPERCGHLP RPNITQSCQL RLCGHWEVGS PWSQCSVRCG RGQRSRQVRC VGNNGDEVSE QECASGPPQP PSREACDMGP CTTAWFHSDW SSKCSAECGT GIQRRSVVCL GSGAALGPGQ GEAGAGTGQS CPTGSRPPDM RACSLGPCER TWRWYTGPWG ECSSECGSGT QRRDIICVSK LGTEFNVTSP SNCSHLPRPP ALQPCQGQAC QDRWFSTPWS PCSRSCQGGT QTREVQCLST NQTLSTRCPP QLRPSRKRPC NSQPCSQRPD DQCKDSSPHC PLVVQARLCV YPYYTATCCR SCAHVLERSP QDPS
 Chromosome Location    Chromosome: 1; NC_000001.10 (150521846..150533413). Location: 1q21.3
 OMIM    225200
 3D Structure    ModBase 3D Structure for Q6UY14
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human ADAMTSL4.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2.
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 Immunogen    Full length human ADAMTSL4, aa1-424 (AAH27478.1).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-ADAMTSL4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ADAMTSL4 antibody

   Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis.
 Product Categories/Family for anti-ADAMTSL4 antibody    Antibodies; Abs to Matrix Metalloproteinases
 Applications Tested/Suitable for anti-ADAMTSL4 antibody   

Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-ADAMTSL4 antibody    Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml
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NCBI/Uniprot data below describe general gene information for ADAMTSL4. It may not necessarily be applicable to this product.
 NCBI GI #    56788359
 NCBI GeneID    54507
 NCBI Accession #    NP_079284.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_025008.3 [Other Products]
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 UniProt Primary Accession #    Q6UY14 [Other Products]
 UniProt Secondary Accession #    Q5T5F7; Q6IPM6; Q8N643; Q9HBS6 [Other Products]
 UniProt Related Accession #    Q6UY14 [Other Products]
 Molecular Weight    116,545 Da [Similar Products]
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 NCBI Official Full Name    ADAMTS-like protein 4 isoform 2
 NCBI Official Synonym Full Names    ADAMTS-like 4
 NCBI Official Symbol    ADAMTSL4 [Similar Products]
 NCBI Official Synonym Symbols   
TSRC1; ECTOL2
[Similar Products]
 NCBI Protein Information    ADAMTS-like protein 4; ADAMTSL-4; thrombospondin repeat containing 1; thrombospondin repeat-containing protein 1
 UniProt Protein Name    ADAMTS-like protein 4
 UniProt Synonym Protein Names   
Thrombospondin repeat-containing protein 1
 Protein Family    ADAMTS-like protein
 UniProt Gene Name    ADAMTSL4 [Similar Products]
 UniProt Synonym Gene Names    TSRC1; ADAMTSL-4 [Similar Products]
 UniProt Entry Name    ATL4_HUMAN
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 NCBI Summary for ADAMTSL4    This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADAMTSL4    Function: Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis. Ref.7 Ref.10

Subunit structure: Interacts with CTSB. Interacts with FBN1. Ref.7 Ref.10

Subcellular location: Secreted › extracellular space › extracellular matrix. Note: Colocalizes with FMN1 microfibrils in the eye ECM. Ref.10

Tissue specificity: Expressed in colon, heart, leukocyte, liver, lung, skeletal muscle, spleen, testis and placenta. Weaker expression in bone marrow, brain tissue, kidney and pancreas. Expression studies in fetal tissues reveal strong expression in heart, kidney, liver, lung and skeletal muscle, but weaker expression in fetal brain and skin. Ref.8

Post-translational modification: N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion

By similarity. Ref.10

Involvement in disease: Ectopia lentis 2, isolated, autosomal recessive (ECTOL2) [MIM:225200]: An ocular abnormality characterized by partial or complete displacement of the lens from its space resulting from defective zonule formation.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8Ectopia lentis et pupillae (ECTOLP) [MIM:225200]: An ocular abnormality characterized by displacement of the lenses and the pupils, associated with other ocular anomalies, but without systemic manifestations. The condition is usually bilateral, with the lenses and pupils displaced in opposite directions. Additional signs include enlarged corneal diameter, increased corneal astigmatism, increased anterior chamber depth, thinning and flattening of the iris with loss of crypts, angle malformation caused by enlarged iris processes, persistent pupillary membrane, loss of zonular fibers, tilted disk, and increased axial length. Secondary manifestations include refractive errors, glaucoma, early cataract development, and retinal detachment. Membrane formation on the posterior aspect of the iris has been observed both in histologic sections and on ultrasound biomicroscopy.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9

Sequence similarities: Contains 1 PLAC domain.Contains 6 TSP type-1 domains.

Caution: Although similar to members of the ADAMTS family, it lacks the metalloprotease and disintegrin-like domains which are typical of that family.

Sequence caution: The sequence AAG17217.1 differs from that shown. Reason: Frameshift at position 719.
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 Research Articles on ADAMTSL4    1. This is the first detailed report of a possible genetic determinant of craniosynostosis with ectopia lentis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADAMTSL4 antibodyDiseases associated with anti-ADAMTSL4 antibody
 Reference Product  PubMed Publications
 FBN1 antibody  >6 publications with ADAMTSL4 and FBN1
 Disease Name  Pubmed Publications
 Musculoskeletal Diseases Antibodies  >3 publications with ADAMTSL4 and Musculoskeletal Diseases
 Cardiovascular Diseases Antibodies  >2 publications with ADAMTSL4 and Cardiovascular Diseases
 Neoplasms Antibodies  >2 publications with ADAMTSL4 and Neoplasms
 Immune System Diseases Antibodies  >1 publications with ADAMTSL4 and Immune System Diseases
 Ovarian Neoplasms Antibodies  >1 publications with ADAMTSL4 and Ovarian Neoplasms
 Necrosis Antibodies  >1 publications with ADAMTSL4 and Necrosis
 ECTOPIA LENTIS 2, ISOLATED, AUTOSOMAL RECESSIVE Antibodies  >1 publications with ADAMTSL4 and ECTOPIA LENTIS 2, ISOLATED, AUTOSOMAL RECESSIVE
Organs/Tissues associated with anti-ADAMTSL4 antibody
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >7 publications with ADAMTSL4 and Eye
 Blood Antibodies  >2 publications with ADAMTSL4 and Blood
 Connective Tissue Antibodies  >2 publications with ADAMTSL4 and Connective Tissue
 Embryonic Tissue Antibodies  >1 publications with ADAMTSL4 and Embryonic Tissue
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