AAH15982.2
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,245 Da
NCBI Official Full Name
ADCY4 protein, partial
NCBI Official Synonym Full Names
adenylate cyclase 4
NCBI Official Synonym Symbols
NCBI Protein Information
adenylate cyclase type 4; ATP pyrophosphate-lyase 4; adenylate cyclase type IV; adenylyl cyclase 4
UniProt Protein Name
Adenylate cyclase type 4
UniProt Synonym Protein Names
ATP pyrophosphate-lyase 4; Adenylate cyclase type IV; Adenylyl cyclase 4
UniProt Entry Name
ADCY4_HUMAN
NCBI Summary for ADCY4
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
UniProt Comments for ADCY4
ADCY4: This is a membrane-bound, calmodulin-insensitive adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Protein type: Lyase; Nucleotide Metabolism - purine; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family; Membrane protein, integral; EC 4.6.1.1; Adenylyl cyclase
Chromosomal Location of Human Ortholog: 14q12
Cellular Component: membrane; cytoplasm; dendrite; integral to membrane; plasma membrane
Molecular Function: protein binding; metal ion binding; ATP binding; adenylate cyclase activity
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; signal transduction; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; synaptic transmission; phospholipase C activation; energy reserve metabolic process; renal water homeostasis; innate immune response; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; transmembrane transport
Research Articles on ADCY4
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Pathways associated with anti-ADCY4 antibody
Organs/Tissues associated with anti-ADCY4 antibody
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