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anti-ADH5 antibody :: Goat ADH5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420931
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADH5, Polyclonal Antibody

 Also Known As   

Goat anti-ADH5 Antibody

 Product Synonym Names    ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide; ADH-3; ADHX; FDH; Alcohol dehydrogenase (class III), chi polypeptide; class III alcohol dehydrogenase 5 chi subunit; formaldehyde dehydrogenase; glutathione-dependent formaldehyde dehydrogenase; ADH5 antibody; alcohol dehydrogenase 5 (class III); chi polypeptide antibody; ADH-3 antibody; ADHX antibody; FDH antibody; Alcohol dehydrogenase (class III); chi polypeptide antibody; class III alcohol dehydrogenase 5 chi subunit antibody; formaldehyde dehydrogenase antibody; glutathione-dependent formaldehyde dehydrogenase antibody; GSNOR antibody
 Product Gene Name   

anti-ADH5 antibody

[Similar Products]
 Antibody/Peptide Pairs    ADH5 peptide (MBS425283) is used for blocking the activity of ADH5 antibody (MBS420931)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KKIKVDEFVT HN
 OMIM    103710
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-KKIKVDEFVTHN, from the internal region of the protein sequence according to NP_000662.3.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-ADH5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ADH5 antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ADH5 antibody    Peptide ELISA: Antibody detection limit dilution 1: 4000.
Immunohistochemistry: An anonymous customer found positive results in IHC on Rat penile tissue.
Western Blot: Approx 38kDa band observed in Human Testis lysates (calculated MW of 39.7kDa according to NP_000662.3). Recommended concentration: 0.5-1.5ug/ml. An anonymous customer found positive results in WB on Rat penis tissue. An anonymous customer found positive results in WB on Mouse penile tissue.
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 Western Blot (WB) of anti-ADH5 antibody    (0.5ug/ml) staining of Human Testis lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-ADH5 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ADH5. It may not necessarily be applicable to this product.
 NCBI GI #    71565154
 NCBI GeneID    128
 NCBI Accession #    NP_000662.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000671.4 [Other Products]
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 UniProt Secondary Accession #    Q6FHR2 [Other Products]
 UniProt Related Accession #    P11766 [Other Products]
 Molecular Weight    39,724 Da
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 NCBI Official Full Name    alcohol dehydrogenase class-3
 NCBI Official Synonym Full Names    alcohol dehydrogenase 5 (class III), chi polypeptide
 NCBI Official Symbol    ADH5 [Similar Products]
 NCBI Official Synonym Symbols   
FDH; ADHX; ADH-3; FALDH; GSNOR; GSH-FDH; HEL-S-60p
[Similar Products]
 NCBI Protein Information    alcohol dehydrogenase class-3
 UniProt Protein Name    Alcohol dehydrogenase class-3
 UniProt Synonym Protein Names   
Alcohol dehydrogenase 5; Alcohol dehydrogenase class chi chain; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-); FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284)
 Protein Family    Alcohol dehydrogenase
 UniProt Gene Name    ADH5 [Similar Products]
 UniProt Synonym Gene Names    FALDH; FDH; GSH-FDH [Similar Products]
 UniProt Entry Name    ADHX_HUMAN
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 NCBI Summary for ADH5    This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]
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 UniProt Comments for ADH5    ADH5: Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

Protein type: Lipid Metabolism - fatty acid; Amino Acid Metabolism - tyrosine; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.1.1.284; Oxidoreductase; Energy Metabolism - methane; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Cofactor and Vitamin Metabolism - retinol; EC 1.1.1.1; Mitochondrial; Xenobiotic Metabolism - metabolism by cytochrome P450

Chromosomal Location of Human Ortholog: 4q23

Cellular Component: cytosol; mitochondrion

Molecular Function: alcohol dehydrogenase activity; electron carrier activity; fatty acid binding; formaldehyde dehydrogenase activity; protein homodimerization activity; S-(hydroxymethyl)glutathione dehydrogenase activity; zinc ion binding

Biological Process: ethanol oxidation; formaldehyde catabolic process; peptidyl-cysteine S-nitrosylation; positive regulation of blood pressure; respiratory system process; response to lipopolysaccharide; response to nitrosative stress; response to redox state; retinoid metabolic process
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 Research Articles on ADH5    1. ADH5 counteracts neuronal differentiation of neural stem cells and this effect can be reversed by pharmacological inhibition of ADH5.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADH5 antibodyPathways associated with anti-ADH5 antibody
 Reference Product  PubMed Publications
 ALDH1A1 antibody  >5 publications with ADH5 and ALDH1A1
 ALDH3A1 antibody  >1 publications with ADH5 and ALDH3A1
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Ethanol Oxidation Pathway antibodies  Ethanol Oxidation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
Diseases associated with anti-ADH5 antibodyOrgans/Tissues associated with anti-ADH5 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >8 publications with ADH5 and Inflammation
 Heart Diseases Antibodies  >6 publications with ADH5 and Heart Diseases
 Cardiovascular Diseases Antibodies  >6 publications with ADH5 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >5 publications with ADH5 and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >4 publications with ADH5 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >2 publications with ADH5 and Liver Diseases
 Fibrosis Antibodies  >2 publications with ADH5 and Fibrosis
 Micronuclei, Chromosome-Defective Antibodies  >2 publications with ADH5 and Micronuclei, Chromosome-Defective
 Edema Antibodies  >1 publications with ADH5 and Edema
 Liver Neoplasms Antibodies  >1 publications with ADH5 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >18 publications with ADH5 and Liver
 Blood Antibodies  >17 publications with ADH5 and Blood
 Lung Antibodies  >10 publications with ADH5 and Lung
 Muscle Antibodies  >10 publications with ADH5 and Muscle
 Heart Antibodies  >9 publications with ADH5 and Heart
 Kidney Antibodies  >5 publications with ADH5 and Kidney
 Vascular Antibodies  >5 publications with ADH5 and Vascular
 Brain Antibodies  >5 publications with ADH5 and Brain
 Spleen Antibodies  >3 publications with ADH5 and Spleen
 Bone Antibodies  >3 publications with ADH5 and Bone
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