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anti-ADORA2A antibody :: Rabbit anti-Human ADORA2A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS853220
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADORA2A, Polyclonal Antibody

 Also Known As   

ADORA2A Antibody

 Product Gene Name   

anti-ADORA2A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    102776
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Lyophilized ADORA2A antibody purified by protein affinity column containing 0.02% NaN3
 Concentration    100ug/200ul (lot specific)
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 Source Note    Rabbit polyclonal ADORA2A (1) antibody was raised against a recombinate human ADORA2A protein 290-412aa (BC013780).
 Reactivity Note    Predicted: Mouse, Rat; Not yet tested in other species.
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 Preparation and Storage    Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
 Other Notes    Small volumes of anti-ADORA2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ADORA2A antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-ADORA2A antibody   

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-ADORA2A antibody    ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:500-1:1,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user.
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 Testing Data of anti-ADORA2A antibody    anti-ADORA2A antibody Testing Data image
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 Testing Data #2 of anti-ADORA2A antibody    anti-ADORA2A antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for ADORA2A. It may not necessarily be applicable to this product.
 NCBI GI #    5921992
 NCBI GeneID    135
 NCBI Accession #    NP_000666.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000675.5 [Other Products]
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 UniProt Secondary Accession #    B2R7E0 [Other Products]
 UniProt Related Accession #    P29274 [Other Products]
 Molecular Weight    44,707 Da
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 NCBI Official Full Name    adenosine receptor A2a
 NCBI Official Synonym Full Names    adenosine A2a receptor
 NCBI Official Symbol    ADORA2A [Similar Products]
 NCBI Official Synonym Symbols   
A2aR; RDC8; ADORA2
[Similar Products]
 NCBI Protein Information    adenosine receptor A2a; adenosine receptor subtype A2a
 UniProt Protein Name    Adenosine receptor A2a
 Protein Family    Adenosine receptor
 UniProt Gene Name    ADORA2A [Similar Products]
 UniProt Synonym Gene Names    ADORA2 [Similar Products]
 UniProt Entry Name    AA2AR_HUMAN
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 NCBI Summary for ADORA2A    This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
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 UniProt Comments for ADORA2A    ADORA2A: one of several receptor subtypes for adenosine. A G-protein coupled receptor. Activation is mediated by G proteins which activate adenylyl cyclase. Abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 22q11.23

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: identical protein binding; protein binding; enzyme binding; adenosine receptor activity, G-protein coupled

Biological Process: central nervous system development; nerve growth factor receptor signaling pathway; blood circulation; apoptosis; adenylate cyclase activation; phagocytosis; G-protein signaling, coupled to cAMP nucleotide second messenger; cell-cell signaling; sensory perception; cellular defense response; cAMP biosynthetic process; blood coagulation; inflammatory response; adenosine receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
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 Research Articles on ADORA2A    1. This study demonistrated that statistically significant lower levels of A2AR mRNA in vascular dementia compared to Alzheimer's disease subjects.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADORA2A antibodyPathways associated with anti-ADORA2A antibody
 Reference Product  PubMed Publications
 ADM antibody  >2 publications with ADORA2A and ADM
 DRD5 antibody  >2 publications with ADORA2A and DRD5
 DRD1 antibody  >2 publications with ADORA2A and DRD1
 Products by Pathway  Pathway Diagram
 Activation Of TRKA Receptors Pathway antibodies  Activation Of TRKA Receptors Pathway Diagram
 Adenosine P1 Receptors Pathway antibodies  Adenosine P1 Receptors Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
Diseases associated with anti-ADORA2A antibodyOrgans/Tissues associated with anti-ADORA2A antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >19 publications with ADORA2A and Inflammation
 Genetic Predisposition to Disease Antibodies  >18 publications with ADORA2A and Genetic Predisposition to Disease
 Anxiety Disorders Antibodies  >10 publications with ADORA2A and Anxiety Disorders
 Disease Models, Animal Antibodies  >10 publications with ADORA2A and Disease Models, Animal
 Movement Disorders Antibodies  >7 publications with ADORA2A and Movement Disorders
 Panic Disorder Antibodies  >6 publications with ADORA2A and Panic Disorder
 Parkinson Disease Antibodies  >3 publications with ADORA2A and Parkinson Disease
 Cognition Disorders Antibodies  >3 publications with ADORA2A and Cognition Disorders
 Hypertension Antibodies  >3 publications with ADORA2A and Hypertension
 Amphetamine-Related Disorders Antibodies  >2 publications with ADORA2A and Amphetamine-Related Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >32 publications with ADORA2A and Brain
 Blood Antibodies  >21 publications with ADORA2A and Blood
 Vascular Antibodies  >9 publications with ADORA2A and Vascular
 Eye Antibodies  >4 publications with ADORA2A and Eye
 Lung Antibodies  >4 publications with ADORA2A and Lung
 Liver Antibodies  >3 publications with ADORA2A and Liver
 Heart Antibodies  >2 publications with ADORA2A and Heart
 Embryonic Tissue Antibodies  >2 publications with ADORA2A and Embryonic Tissue
 Intestine Antibodies  >1 publications with ADORA2A and Intestine
 Stomach Antibodies  >1 publications with ADORA2A and Stomach
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