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anti-ADORA2B antibody :: Rabbit ADORA2B Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS153447
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADORA2B, Polyclonal Antibody

★Popular Item★
 Also Known As   

ADORA2B Antibody

 Product Synonym Names    Adenosine receptor A2b; ADORA2; adenosine A2b receptor
 Product Gene Name   

anti-ADORA2B antibody

[Similar Products]
 Antibody/Peptide Pairs    ADORA2B peptide (MBS153991) is used for blocking the activity of ADORA2B antibody (MBS153447)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600446
 3D Structure    ModBase 3D Structure for P29275
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    ADORA2B antibody is human, mouse and rat reactive. At least two isoforms of ADORA2B are known to exist; this antibody will detect both isoforms. ADORA2B antibody is predicted to not cross-react with ADORA2A.
 Purity/Purification    ADORA2B antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    ADORA2B antibody was raised against a 19 amino acid peptide near the amino terminus of human ADORA2B.
 Buffer    ADORA2B antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    ADORA2B antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
 Other Notes    Small volumes of anti-ADORA2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ADORA2B antibody

   The adenosine receptor ADORA2B is a member of the G protein-coupled receptor superfamily and is an integral membrane protein that stimulates adenylate cyclase activity in the presence of adenosine (1,2). Extracellular adenosine triggers a potent anti-inflammatory response that is mediated in part by ADORA2B including the stimulation of IL-10 production (3-5). Activation of ADORA2B can also enhance the abundance of regulatory T cells (Tregs), a class of cells that work to constrain inflammation (6).
 Applications Tested/Suitable for anti-ADORA2B antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-ADORA2B antibody    ADORA2B antibody can be used for detection of ADORA2B by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-ADORA2B antibody    Western blot analysis of ADORA2B in mouse colon tissue lysate with ADORA2B antibody at (A) 0.5 and (B) 1 μg/ml.
anti-ADORA2B antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-ADORA2B antibody    Immunofluorescence of ADORA2B in rat colon tissue with ADORA2B antibody at 20 μg/mL.
anti-ADORA2B antibody Immunofluorescence (IF) image
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 Immunohistochemistry (IHC) of anti-ADORA2B antibody    Immunohistochemistry of ADORA2B in rat colon tissue with ADORA2B antibody at 5 μg/mL.
anti-ADORA2B antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ADORA2B. It may not necessarily be applicable to this product.
 NCBI GI #    4501951
 NCBI GeneID    136
 NCBI Accession #    NP_000667 [Other Products]
 NCBI GenBank Nucleotide #    NM_000676.2 [Other Products]
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 UniProt Primary Accession #    P29275 [Other Products]
 UniProt Related Accession #    P29275 [Other Products]
 Molecular Weight    Predicted: 37 kDa

Observed: 41 kDa
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 NCBI Official Full Name    adenosine receptor A2b
 NCBI Official Synonym Full Names    adenosine A2b receptor
 NCBI Official Symbol    ADORA2B [Similar Products]
 NCBI Official Synonym Symbols   
ADORA2
[Similar Products]
 NCBI Protein Information    adenosine receptor A2b
 UniProt Protein Name    Adenosine receptor A2b
 Protein Family    Adenosine receptor
 UniProt Gene Name    ADORA2B [Similar Products]
 UniProt Entry Name    AA2BR_HUMAN
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 NCBI Summary for ADORA2B    This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADORA2B    ADORA2B: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 17p12

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: adenosine receptor activity, G-protein coupled

Biological Process: relaxation of vascular smooth muscle; activation of MAPK activity; adenylate cyclase activation; positive regulation of interleukin-6 production; positive regulation of mast cell degranulation; positive regulation of guanylate cyclase activity; excretion; G-protein signaling, adenylate cyclase activating pathway; positive regulation of chemokine production; G-protein coupled receptor protein signaling pathway; positive regulation of chronic inflammatory response to non-antigenic stimulus; cellular response to extracellular stimulus; cellular defense response; JNK cascade; adenosine receptor signaling pathway
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 Research Articles on ADORA2B    1. Data indicate adenosine receptor ADORA2B as the specific receptor and signalling pathway for the metabolite 5'-methylthioadenosine (MTA).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADORA2B antibodyPathways associated with anti-ADORA2B antibody
 Reference Product  PubMed Publications
 ADCY9 antibody  >1 publications with ADORA2B and ADCY9
 MYB antibody  >1 publications with ADORA2B and MYB
 DRD5 antibody  >1 publications with ADORA2B and DRD5
 DRD1 antibody  >1 publications with ADORA2B and DRD1
 ADM antibody  >1 publications with ADORA2B and ADM
 Products by Pathway  Pathway Diagram
 Adenosine P1 Receptors Pathway antibodies  Adenosine P1 Receptors Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
Diseases associated with anti-ADORA2B antibodyOrgans/Tissues associated with anti-ADORA2B antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >18 publications with ADORA2B and Inflammation
 Cardiovascular Diseases Antibodies  >11 publications with ADORA2B and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >7 publications with ADORA2B and Disease Models, Animal
 Hypertension Antibodies  >6 publications with ADORA2B and Hypertension
 Nervous System Diseases Antibodies  >6 publications with ADORA2B and Nervous System Diseases
 Kidney Diseases Antibodies  >5 publications with ADORA2B and Kidney Diseases
 Heart Diseases Antibodies  >5 publications with ADORA2B and Heart Diseases
 Edema Antibodies  >2 publications with ADORA2B and Edema
 Fibrosis Antibodies  >2 publications with ADORA2B and Fibrosis
 Pneumonia Antibodies  >2 publications with ADORA2B and Pneumonia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >19 publications with ADORA2B and Blood
 Lung Antibodies  >9 publications with ADORA2B and Lung
 Heart Antibodies  >6 publications with ADORA2B and Heart
 Brain Antibodies  >6 publications with ADORA2B and Brain
 Intestine Antibodies  >3 publications with ADORA2B and Intestine
 Eye Antibodies  >3 publications with ADORA2B and Eye
 Stomach Antibodies  >2 publications with ADORA2B and Stomach
 Ascites Antibodies  >1 publications with ADORA2B and Ascites
 Prostate Antibodies  >1 publications with ADORA2B and Prostate
 Placenta Antibodies  >1 publications with ADORA2B and Placenta
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