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anti-ADRA1A antibody :: Rabbit ADRA1A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS126515
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADRA1A, Polyclonal Antibody

 Also Known As   

ADRA1A Polyclonal Antibody

 Product Synonym Names    ADRA1C; ADRA1L1; ALPHA1AAR
 Product Gene Name   

anti-ADRA1A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    104221
 3D Structure    ModBase 3D Structure for P35348
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Route    Synthetic Peptide
 Immunogen    A synthetic peptide of human ADRA1A
 Calculated Molecular Weight    52kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-ADRA1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ADRA1A antibody

   ADRA1A, also named as ADRA1C, belongs to the G-protein coupled receptor 1 family. ADRA1A mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. The antibody is specific to ADRA1A.
 Product Categories/Family for anti-ADRA1A antibody    Polyclonal
 Applications Tested/Suitable for anti-ADRA1A antibody   

Western Blot (WB)

 Application Notes for anti-ADRA1A antibody    WB: 1:500 - 1:2000
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 Western Blot (WB) of anti-ADRA1A antibody    Western blot analysis of extracts of various cell lines, using ADRA1A antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
anti-ADRA1A antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ADRA1A. It may not necessarily be applicable to this product.
 NCBI GI #    1168246
 NCBI GeneID    148
 NCBI Accession #    P35348.2 [Other Products]
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 UniProt Primary Accession #    P35348 [Other Products]
 UniProt Secondary Accession #    O60451; Q13675; Q13729; A8K0I3; B0ZBD1; B0ZBD2; B0ZBD4; B0ZBD5; B0ZBD6; B0ZBD8; B0ZBD9 [Other Products]
 UniProt Related Accession #    P35348 [Other Products]
 Molecular Weight    466
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 NCBI Official Full Name    Alpha-1A adrenergic receptor
 NCBI Official Synonym Full Names    adrenoceptor alpha 1A
 NCBI Official Symbol    ADRA1A [Similar Products]
 NCBI Official Synonym Symbols   
ADRA1C; ADRA1L1; ALPHA1AAR
[Similar Products]
 NCBI Protein Information    alpha-1A adrenergic receptor; alpha-1A adrenoceptor; alpha-1A adrenoreceptor; G protein coupled receptor; alpha-1C adrenergic receptor; adrenergic, alpha-1A-, receptor variant 1; adrenergic, alpha-1A-, receptor variant 3; adrenergic, alpha-1A-, receptor variant 5; adrenergic, alpha-1A-, receptor variant 8; adrenergic, alpha-1A-, receptor variant 11
 UniProt Protein Name    Alpha-1A adrenergic receptor
 UniProt Synonym Protein Names   
Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c
 Protein Family    Alpha-1A adrenergic receptor
 UniProt Gene Name    ADRA1A [Similar Products]
 UniProt Synonym Gene Names    ADRA1C; Alpha-1A adrenoceptor [Similar Products]
 UniProt Entry Name    ADA1A_HUMAN
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 NCBI Summary for ADRA1A    Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADRA1A    ADRA1A: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 8p21.2

Cellular Component: nuclear membrane; integral to plasma membrane; T-tubule; plasma membrane; nucleus; Z disc

Molecular Function: protein heterodimerization activity; alpha1-adrenergic receptor activity

Biological Process: apoptosis; response to hormone stimulus; positive regulation of systemic arterial blood pressure; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; signal transduction; negative regulation of cell proliferation; elevation of cytosolic calcium ion concentration; smooth muscle contraction; cell-cell signaling; positive regulation of MAPKKK cascade; positive regulation of action potential; positive regulation of smooth muscle contraction; cell growth; aging; adult heart development; response to drug; positive regulation of the force of heart contraction by epinephrine-norepinephrine; positive regulation of synaptic transmission, GABAergic; micturition; negative regulation of heart rate in baroreceptor response to increased systemic arterial blood pressure; organ growth; G-protein coupled receptor protein signaling pathway; negative regulation of Rho protein signal transduction; phospholipase C activation; positive regulation of vasoconstriction; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of heart rate by epinephrine-norepinephrine
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 Research Articles on ADRA1A    1. alpha1-AR expression is greater on nerve fibers in skin affected by complex regional pain syndrome type II (CRPS) than in unaffected skin from the same patient or from pain-free controls.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ADRA1A antibodyDiseases associated with anti-ADRA1A antibody
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenoceptors Pathway antibodies  Adrenoceptors Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >690 publications with ADRA1A and Hypertension
 Heart Diseases Antibodies  >518 publications with ADRA1A and Heart Diseases
 Hyperplasia Antibodies  >301 publications with ADRA1A and Hyperplasia
 Prostatic Hyperplasia Antibodies  >280 publications with ADRA1A and Prostatic Hyperplasia
 Prostatic Diseases Antibodies  >219 publications with ADRA1A and Prostatic Diseases
 Ischemia Antibodies  >216 publications with ADRA1A and Ischemia
 Heart Failure Antibodies  >207 publications with ADRA1A and Heart Failure
 Urologic Diseases Antibodies  >175 publications with ADRA1A and Urologic Diseases
 Pain Antibodies  >170 publications with ADRA1A and Pain
 Hypotension Antibodies  >165 publications with ADRA1A and Hypotension
Organs/Tissues associated with anti-ADRA1A antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2274 publications with ADRA1A and Brain
 Liver Antibodies  >464 publications with ADRA1A and Liver
 Testis Antibodies  >20 publications with ADRA1A and Testis
 Uncharacterized Tissue Antibodies  >2 publications with ADRA1A and Uncharacterized Tissue
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