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anti-ADRA1B antibody :: Rabbit ADRA1B Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240877
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADRA1B, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human ADRA1B

 Product Synonym Names    Anti-ADRA1B Antibody (C-Terminus) IHC-plus; ADRA1B; Alpha 1b; Alpha-1B adrenergic receptor; Alpha-1b-adrenergic; Alpha-1B-adrenergic receptor; Alpha1b; Adrenoceptor alpha 1B; Alpha-1B adrenoreceptor; Alpha1B-AR; Alpha1beta-AR; ALPHA1BAR; ADRA1; Alpha-1B adrenoceptor; Alpha1b-adrenergic; Human ADRA1B
 Product Gene Name   

anti-ADRA1B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    104220
 3D Structure    ModBase 3D Structure for P35368
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Gorilla, Human
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
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 Specificity    Human ADRA1B. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic 20 amino acid peptide from C-terminal cytoplasmic domain of human ADRA1B. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey, Marmoset (95%); Mouse, Hamster, Elephant (85%).
 Immunogen Type    Synthetic peptide
 Immunogen    ADRA1B antibody was raised against synthetic 20 amino acid peptide from C-terminal cytoplasmic domain of human ADRA1B. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey, Marmoset (95%); Mouse, Hamster, Elephant (85%).
 Antigen Modification    C-Terminus
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 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-ADRA1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ADRA1B antibody

   The alpha-1b adrenoceptor is an Adrenergic Receptor that causes contraction of smooth muscle cells and thereby controls vascular tone, blood pressure, and accelerates the development of atherosclerosis. Decreased alpha-1b adrenoceptor is associated with benign prostatic hyperplasia (BPH). This adrenergic receptor also acts as a proto-oncogene when transfected into cell lines where constitutive activation of the receptor induces neoplastic transformation.
 Product Categories/Family for anti-ADRA1B antibody    Family: GPCR
Subfamily: Adrenergic
 Applications Tested/Suitable for anti-ADRA1B antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-ADRA1B antibody    ELISA, IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-ADRA1B antibody    Anti-ADRA1B antibody IHC of human smooth muscle cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-ADRA1B antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ADRA1B. It may not necessarily be applicable to this product.
 NCBI GI #    4501959
 NCBI GeneID    147
 NCBI Accession #    NP_000670.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000679.3 [Other Products]
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 UniProt Primary Accession #    P35368 [Other Products]
 UniProt Secondary Accession #    B0LPE1 [Other Products]
 UniProt Related Accession #    P35368 [Other Products]
 Molecular Weight    56,836 Da
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 NCBI Official Full Name    alpha-1B adrenergic receptor
 NCBI Official Synonym Full Names    adrenoceptor alpha 1B
 NCBI Official Symbol    ADRA1B [Similar Products]
 NCBI Official Synonym Symbols   
ADRA1; ALPHA1BAR
[Similar Products]
 NCBI Protein Information    alpha-1B adrenergic receptor; alpha-1B adrenoceptor; alpha-1B adrenoreceptor; alpha-1B-adrenergic receptor; adrenergic, alpha-1B-, receptor
 UniProt Protein Name    Alpha-1B adrenergic receptor
 UniProt Synonym Protein Names   
Alpha-1B adrenoreceptor; Alpha-1B adrenoceptor
 Protein Family    Alpha-1B adrenergic receptor
 UniProt Gene Name    ADRA1B [Similar Products]
 UniProt Synonym Gene Names    Alpha-1B adrenoceptor [Similar Products]
 UniProt Entry Name    ADA1B_HUMAN
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 NCBI Summary for ADRA1B    Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADRA1B    ADRA1B: a G protein-coupled catecholamine receptor that activates mitogenic responses and regulates growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. Can induce neoplastic transformation when transfected into cell lines. Can regulate the phosphorylation status of the STAT3 pathway. Mediates blood pressure and aorta contractile responses induced by alpha-1 agonists. Activates a phosphatidylinositol second messenger system.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q33.3

Cellular Component: nuclear membrane; integral to plasma membrane; plasma membrane; nucleus

Molecular Function: protein heterodimerization activity; alpha1-adrenergic receptor activity

Biological Process: adult heart development; vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure; positive regulation of the force of heart contraction by epinephrine-norepinephrine; multicellular organismal development; response to amphetamine; response to morphine; locomotory behavior; glucose homeostasis; positive regulation of glycogen catabolic process; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; cell proliferation; organ growth; cell-cell signaling; positive regulation of MAPKKK cascade; behavioral response to cocaine; regulation of vasoconstriction; visual learning; blood vessel remodeling; cell growth; positive regulation of heart rate by epinephrine-norepinephrine; negative regulation of glycogen catabolic process
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 Research Articles on ADRA1B    1. Mean alpha-receptor stain rates in renal pelvis were 2.65 +/- 0.74, 1.35 +/- 0.81 and 2.9 +/- 0.30 for alpha 1A, 1B and 1D, respectively. For calyces, the rates are 2.40 +/- 0.82, 1.50 +/- 0.76 and 2.75 +/- 0.44 for alpha 1A, 1B and 1D, respectively.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADRA1B antibodyPathways associated with anti-ADRA1B antibody
 Reference Product  PubMed Publications
 ADRBK1 antibody  >15 publications with ADRA1B and ADRBK1
 TRH antibody  >9 publications with ADRA1B and TRH
 TBXA2R antibody  >7 publications with ADRA1B and TBXA2R
 AGTR1 antibody  >1 publications with ADRA1B and AGTR1
 APP antibody  >1 publications with ADRA1B and APP
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenoceptors Pathway antibodies  Adrenoceptors Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Diseases associated with anti-ADRA1B antibodyOrgans/Tissues associated with anti-ADRA1B antibody
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >687 publications with ADRA1B and Hypertension
 Heart Diseases Antibodies  >517 publications with ADRA1B and Heart Diseases
 Hypertrophy Antibodies  >303 publications with ADRA1B and Hypertrophy
 Hyperplasia Antibodies  >300 publications with ADRA1B and Hyperplasia
 Disease Models, Animal Antibodies  >239 publications with ADRA1B and Disease Models, Animal
 Heart Failure Antibodies  >206 publications with ADRA1B and Heart Failure
 Pain Antibodies  >170 publications with ADRA1B and Pain
 Hypotension Antibodies  >165 publications with ADRA1B and Hypotension
 Cardiomegaly Antibodies  >138 publications with ADRA1B and Cardiomegaly
 Arrhythmias, Cardiac Antibodies  >131 publications with ADRA1B and Arrhythmias, Cardiac
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >2404 publications with ADRA1B and Vascular
 Kidney Antibodies  >519 publications with ADRA1B and Kidney
 Lung Antibodies  >163 publications with ADRA1B and Lung
 Intestine Antibodies  >139 publications with ADRA1B and Intestine
 Bone Antibodies  >44 publications with ADRA1B and Bone
 Uncharacterized Tissue Antibodies  >2 publications with ADRA1B and Uncharacterized Tissue
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