NP_000670
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,836 Da
NCBI Official Full Name
alpha-1B adrenergic receptor
NCBI Official Synonym Full Names
adrenoceptor alpha 1B
NCBI Protein Information
alpha-1B adrenergic receptor
UniProt Protein Name
Alpha-1B adrenergic receptor
UniProt Synonym Protein Names
Alpha-1B adrenoreceptor; Alpha-1B adrenoceptor
UniProt Synonym Gene Names
UniProt Entry Name
ADA1B_HUMAN
NCBI Summary for ADRA1B
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]
UniProt Comments for ADRA1B
ADRA1B: a G protein-coupled catecholamine receptor that activates mitogenic responses and regulates growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. Can induce neoplastic transformation when transfected into cell lines. Can regulate the phosphorylation status of the STAT3 pathway. Mediates blood pressure and aorta contractile responses induced by alpha-1 agonists. Activates a phosphatidylinositol second messenger system.
Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1
Chromosomal Location of Human Ortholog: 5q33.3
Cellular Component: nuclear membrane; integral to plasma membrane; plasma membrane; nucleus
Molecular Function: protein heterodimerization activity; alpha1-adrenergic receptor activity
Biological Process: adult heart development; vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure; positive regulation of the force of heart contraction by epinephrine-norepinephrine; multicellular organismal development; response to amphetamine; response to morphine; locomotory behavior; glucose homeostasis; positive regulation of glycogen catabolic process; G-protein signaling, coupled to cAMP nucleotide second messenger; organ growth; G-protein coupled receptor protein signaling pathway; cell proliferation; positive regulation of MAPKKK cascade; cell-cell signaling; behavioral response to cocaine; regulation of vasoconstriction; visual learning; blood vessel remodeling; cell growth; positive regulation of heart rate by epinephrine-norepinephrine; negative regulation of glycogen catabolic process
Research Articles on ADRA1B
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Products associated with anti-ADRA1B antibody
Pathways associated with anti-ADRA1B antibody
Diseases associated with anti-ADRA1B antibody
Organs/Tissues associated with anti-ADRA1B antibody
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