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anti-ADRA2A antibody :: Rabbit ADRA2A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242887
Unit / Price
0.05 mL  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADRA2A, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal (IgG) to Human ADRA2A

 Product Synonym Names    Anti-ADRA2A Antibody (aa331-380) IHC-plus; ADRA2A; Alpha-2A adrenoreceptor; Alpha-2AAR; Alpha-2AAR subtype C10; ADRA2; ADRA2R; ADRAR; Adrenoceptor alpha 2A; Alpha 2a; Alpha(2A)-AR; Alpha2a; ALPHA2AAR; Alpha-2A adrenoceptor; Adrenergic alpha 2a receptor; Adrenergic alpha 2a receptor; Human ADRA2A
 Product Gene Name   

anti-ADRA2A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    104210
 3D Structure    ModBase 3D Structure for P08913
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Adrenergic Receptor alpha-2A Antibody detects endogenous levels of total Adrenergic Receptor alpha-2A protein.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human Adrenergic Receptor alpha-2A (aa331-380).
 Immunogen    ADRA2A antibody was raised against synthetic peptide from human Adrenergic Receptor alpha-2A (aa331-380).
 Antigen Modification    aa331-380
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 Preparation and Storage    Store at -20 degree C for up to one year.
 Other Notes    Small volumes of anti-ADRA2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ADRA2A antibody

   The Alpha 2a- Adrenergic Receptor functions as a post-synaptic receptor that mediates the effects of epinephrine and norepinephrine. This adrenoceptor also functions as a presynaptic autoreceptor, inhibiting the subsequent release of neurotransmitter, especially epinephrine, from sympathetic nerves and from adrenergic neurons in the central nervous system. Adrenergic Alpha-2A Receptor polymorphisms have been identified in individuals with Tourette's syndrome.
 Product Categories/Family for anti-ADRA2A antibody    Family: GPCR
Subfamily: Adrenergic
 Applications Tested/Suitable for anti-ADRA2A antibody   

Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-ADRA2A antibody    ELISA (1:20000), IF (1:100 - 1:500), IHC-P (10 ug/ml), WB (1:500 - 1:1000)
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 Immunohistochemistry (IHC) of anti-ADRA2A antibody    Anti-ADRA2A antibody IHC of human colon, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-ADRA2A antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-ADRA2A antibody    Immunofluorescence of NIH-3T3 cells, using Adrenergic Receptor alpha-2A Antibody. The picture on the right is treated with the synthesized peptide.
anti-ADRA2A antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-ADRA2A antibody    Western blot of extracts from Jurkat/LOVO cells, using Adrenergic Receptor alpha-2A Antibody. The lane on the right is treated with the synthesized peptide.
anti-ADRA2A antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ADRA2A. It may not necessarily be applicable to this product.
 NCBI GI #    194353970
 NCBI GeneID    150
 NCBI Accession #    NP_000672.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000681.3 [Other Products]
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 UniProt Primary Accession #    P08913 [Other Products]
 UniProt Secondary Accession #    Q2I8G2; Q2XN99; Q86TH8; Q9BZK1; B0LPF6 [Other Products]
 UniProt Related Accession #    P08913 [Other Products]
 Molecular Weight    48,957 Da
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 NCBI Official Full Name    alpha-2A adrenergic receptor
 NCBI Official Synonym Full Names    adrenoceptor alpha 2A
 NCBI Official Symbol    ADRA2A [Similar Products]
 NCBI Official Synonym Symbols   
ADRA2; ADRAR; ZNF32; ADRA2R; ALPHA2AAR
[Similar Products]
 NCBI Protein Information    alpha-2A adrenergic receptor; alpha-2A adrenoceptor; alpha-2AAR subtype C10; alpha-2A adrenoreceptor; adrenergic, alpha-2A-, receptor; alpha-2 adrenergic receptor subtype C10; alpha-2-adrenergic receptor, platelet type
 UniProt Protein Name    Alpha-2A adrenergic receptor
 UniProt Synonym Protein Names   
Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2AAR
 Protein Family    Alpha-2A adrenergic receptor
 UniProt Gene Name    ADRA2A [Similar Products]
 UniProt Synonym Gene Names    ADRA2R; ADRAR; Alpha-2A adrenoceptor; Alpha-2AAR [Similar Products]
 UniProt Entry Name    ADA2A_HUMAN
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 NCBI Summary for ADRA2A    Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADRA2A    ADRA2A: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q25.2

Cellular Component: basolateral plasma membrane; integral to plasma membrane; cytoplasm; plasma membrane; synapse; receptor complex

Molecular Function: protein binding; protein homodimerization activity; alpha-2C adrenergic receptor binding; protein heterodimerization activity; thioesterase binding; alpha2-adrenergic receptor activity; norepinephrine binding; alpha-1B adrenergic receptor binding; epinephrine binding; protein kinase binding; heterotrimeric G-protein binding

Biological Process: fear response; negative regulation of calcium ion-dependent exocytosis; positive regulation of potassium ion transport; female pregnancy; thermoception; glucose homeostasis; positive regulation of vasodilation; signal transduction; positive regulation of membrane protein ectodomain proteolysis; Rho protein signal transduction; intestinal absorption; negative regulation of insulin secretion; positive regulation of MAP kinase activity; negative regulation of cAMP biosynthetic process; positive regulation of epidermal growth factor receptor activity; negative regulation of lipid catabolic process; positive regulation of cell proliferation; DNA replication; positive regulation of cytokine production; platelet activation; negative regulation of calcium ion transport; activation of protein kinase B; negative regulation of adenylate cyclase activity; cellular response to hormone stimulus; G-protein coupled receptor protein signaling pathway; regulation of vasoconstriction; Ras protein signal transduction; activation of protein kinase activity; energy reserve metabolic process; negative regulation of epinephrine secretion; actin cytoskeleton organization and biogenesis; blood coagulation; cell motility; regulation of insulin secretion; acute inflammatory response; positive regulation of cell migration
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 Research Articles on ADRA2A    1. The study data indicated that carriage of the ADRA2A rs1800544 GG genotype was associated with body mass index reduction in schizophrenia patients following switching of antipsychotics to aripiprazole and ziprasidone.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADRA2A antibodyPathways associated with anti-ADRA2A antibody
 Reference Product  PubMed Publications
 POMC antibody  >93 publications with ADRA2A and POMC
 NPY antibody  >93 publications with ADRA2A and NPY
 RGS4 antibody  >7 publications with ADRA2A and RGS4
 ADCY5 antibody  >6 publications with ADRA2A and ADCY5
 MTNR1B antibody  >3 publications with ADRA2A and MTNR1B
 GNAI2 antibody  >2 publications with ADRA2A and GNAI2
 Products by Pathway  Pathway Diagram
 Adrenaline Signalling Through Alpha-2 Adrenergic Receptor Pathway antibodies  Adrenaline Signalling Through Alpha-2 Adrenergic Receptor Pathway Diagram
 Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway antibodies  Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway Diagram
 Adrenoceptors Pathway antibodies  Adrenoceptors Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (z) Signalling Events Pathway antibodies  G Alpha (z) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
Diseases associated with anti-ADRA2A antibodyOrgans/Tissues associated with anti-ADRA2A antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >920 publications with ADRA2A and Nervous System Diseases
 Hypertension Antibodies  >657 publications with ADRA2A and Hypertension
 Pain Antibodies  >533 publications with ADRA2A and Pain
 Disease Models, Animal Antibodies  >293 publications with ADRA2A and Disease Models, Animal
 Heart Diseases Antibodies  >275 publications with ADRA2A and Heart Diseases
 Hypotension Antibodies  >225 publications with ADRA2A and Hypotension
 Depressive Disorder Antibodies  >168 publications with ADRA2A and Depressive Disorder
 Bradycardia Antibodies  >141 publications with ADRA2A and Bradycardia
 Tachycardia Antibodies  >139 publications with ADRA2A and Tachycardia
 Heart Failure Antibodies  >130 publications with ADRA2A and Heart Failure
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3277 publications with ADRA2A and Brain
 Heart Antibodies  >1222 publications with ADRA2A and Heart
 Nerve Antibodies  >1115 publications with ADRA2A and Nerve
 Kidney Antibodies  >578 publications with ADRA2A and Kidney
 Intestine Antibodies  >275 publications with ADRA2A and Intestine
 Eye Antibodies  >250 publications with ADRA2A and Eye
 Connective Tissue Antibodies  >225 publications with ADRA2A and Connective Tissue
 Pancreas Antibodies  >132 publications with ADRA2A and Pancreas
 Adrenal Gland Antibodies  >123 publications with ADRA2A and Adrenal Gland
 Stomach Antibodies  >117 publications with ADRA2A and Stomach
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