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anti-ADRA2B antibody :: Rabbit anti-Human ADRA2B Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS628940 anti-ADRA2B antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADRA2B, Polyclonal Antibody

 Also Known As   

ADRA2B, ID (Alpha-2B Adrenergic Receptor, Alpha-2B Adrenoreceptor, Alpha-2B Adrenoceptor, Alpha-2BAR, Alpha-2 Adrenergic Receptor Subtype C2, ADRA2L1, ADRA2RL1)

 Product Synonym Names    Anti -ADRA2B, ID (Alpha-2B Adrenergic Receptor, Alpha-2B Adrenoreceptor, Alpha-2B Adrenoceptor, Alpha-2BAR, Alpha-2 Adrenergic Receptor Subtype C2, ADRA2L1, ADRA2RL1)
 Product Gene Name   

anti-ADRA2B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (96778623..96781888, complement). Location: 2p13-q13
 OMIM    104260
 3D Structure    ModBase 3D Structure for P18089
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human ADRA2B.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.09% sodium azide.
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 Immunogen    Synthetic peptide selected from the Center region of human ADRA2B (KLH).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-ADRA2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ADRA2B antibody

   Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.
 Product Categories/Family for anti-ADRA2B antibody    Antibodies; Abs to Receptors
 Applications Tested/Suitable for anti-ADRA2B antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-ADRA2B antibody    Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
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NCBI/Uniprot data below describe general gene information for ADRA2B. It may not necessarily be applicable to this product.
 NCBI GI #    33598960
 NCBI GeneID    151
 NCBI Accession #    NP_000673.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000682.5 [Other Products]
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 UniProt Primary Accession #    P18089 [Other Products]
 UniProt Secondary Accession #    Q4TUH9; Q53RF2; Q9BZK0 [Other Products]
 UniProt Related Accession #    P18089 [Other Products]
 Molecular Weight    49,954 Da [Similar Products]
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 NCBI Official Full Name    alpha-2B adrenergic receptor
 NCBI Official Synonym Full Names    adrenergic, alpha-2B-, receptor
 NCBI Official Symbol    ADRA2B [Similar Products]
 NCBI Official Synonym Symbols   
ADRA2L1; ADRARL1; ADRA2RL1; ALPHA2BAR
[Similar Products]
 NCBI Protein Information    alpha-2B adrenergic receptor; alpha-2BAR; OTTHUMP00000205577; alpha-2B adrenoceptor; alpha-2B adrenoreceptor; G-protein coupled receptor; adrenergic receptor alpha 2B; alpha-2B-adrenergic receptor; alpha-2-adrenergic receptor-like 1; ADRA2B adrenergic, alpha-2B-, receptor; alpha-2 adrenergic receptor subtype C2
 UniProt Protein Name    Alpha-2B adrenergic receptor
 UniProt Synonym Protein Names   
Alpha-2 adrenergic receptor subtype C2; Alpha-2B adrenoreceptor
 Protein Family    Alpha-2B adrenergic receptor
 UniProt Gene Name    ADRA2B [Similar Products]
 UniProt Synonym Gene Names    ADRA2L1; ADRA2RL1 [Similar Products]
 UniProt Entry Name    ADA2B_HUMAN
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 NCBI Summary for ADRA2B    Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences. [provided by RefSeq]
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 UniProt Comments for ADRA2B    ADRA2B: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.

Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q11.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; alpha2-adrenergic receptor activity; epinephrine binding

Biological Process: platelet activation; G-protein coupled receptor protein signaling pathway; cell-cell signaling; activation of protein kinase B; regulation of vascular smooth muscle contraction; MAPKKK cascade; negative regulation of epinephrine secretion; angiogenesis; female pregnancy; positive regulation of neuron differentiation; blood coagulation; positive regulation of blood pressure

Disease: Epilepsy, Familial Adult Myoclonic, 2
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 Research Articles on ADRA2B    1. Alpha2B-adrenergic receptor interaction with tubulin controls its transport from the endoplasmic reticulum to the cell surface
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADRA2B antibodyPathways associated with anti-ADRA2B antibody
 Reference Product  PubMed Publications
 GNAI2 antibody  >2 publications with ADRA2B and GNAI2
 Products by Pathway  Pathway Diagram
 Adrenaline Signalling Through Alpha-2 Adrenergic Receptor Pathway antibodies  Adrenaline Signalling Through Alpha-2 Adrenergic Receptor Pathway Diagram
 Adrenoceptors Pathway antibodies  Adrenoceptors Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (z) Signalling Events Pathway antibodies  G Alpha (z) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
Diseases associated with anti-ADRA2B antibodyOrgans/Tissues associated with anti-ADRA2B antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >812 publications with ADRA2B and Nervous System Diseases
 Hypertension Antibodies  >634 publications with ADRA2B and Hypertension
 Brain Diseases Antibodies  >261 publications with ADRA2B and Brain Diseases
 Neoplasms Antibodies  >152 publications with ADRA2B and Neoplasms
 Bradycardia Antibodies  >136 publications with ADRA2B and Bradycardia
 Inflammation Antibodies  >88 publications with ADRA2B and Inflammation
 Arrhythmias, Cardiac Antibodies  >64 publications with ADRA2B and Arrhythmias, Cardiac
 Hypertrophy Antibodies  >48 publications with ADRA2B and Hypertrophy
 Glioma Antibodies  >43 publications with ADRA2B and Glioma
 Parkinson Disease Antibodies  >26 publications with ADRA2B and Parkinson Disease
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >1150 publications with ADRA2B and Heart
 Nerve Antibodies  >1055 publications with ADRA2B and Nerve
 Kidney Antibodies  >565 publications with ADRA2B and Kidney
 Ganglia Antibodies  >168 publications with ADRA2B and Ganglia
 Embryonic Tissue Antibodies  >35 publications with ADRA2B and Embryonic Tissue
 Uncharacterized Tissue Antibodies  >6 publications with ADRA2B and Uncharacterized Tissue
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