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anti-ADRB3 antibody :: Rabbit anti-Human, Mouse ADRB3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9216255
Western Blot (WB)
Unit / Price
0.05 mL  /  $155 +1 FREE 8GB USB
0.2 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADRB3, Polyclonal Antibody

 Also Known As   

ADRB3 Antibody (C-Term)

 Product Synonym Names    Purified Rabbit Polyclonal Antibody (Pab); Beta-3 adrenergic receptor; Beta-3 adrenoreceptor; Beta-3 adrenoceptor; ADRB3; ADRB3R; B3AR
 Product Gene Name   

anti-ADRB3 antibody

[Similar Products]
 Antibody/Peptide Pairs    ADRB3 peptide (MBS9230424) is used for blocking the activity of ADRB3 antibody (MBS9216255)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    109691
 3D Structure    ModBase 3D Structure for P13945
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 Clonality    Polyclonal
 Isotype    Ig
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    This ADRB3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 255-289 amino acids from human ADRB3.
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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 Antigen Source    Human
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-ADRB3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ADRB3 antibody

   Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
 Product Categories/Family for anti-ADRB3 antibody    Cardiovascular; Metabolism; Neuroscience; Signal Transduction
 Applications Tested/Suitable for anti-ADRB3 antibody   

Western Blot (WB)

 Application Notes for anti-ADRB3 antibody    WB ~~ 1:2000
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 Western Blot (WB) of anti-ADRB3 antibody    All lanes : Anti-ADRB3 Antibody (C-Term) at 1:2000 dilution
Lane 1: mouse adipose tissue lysate
Lane 2: human brain lysate
Lane 3: HepG2 whole cell lysate
Lane 4: HL-60 whole cell lysate
Lane 5: 3T3-L1 whole cell lysate
Lane 6: NCI-H1299 whole cell lysate
Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.

Predicted band size : 44 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.
anti-ADRB3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ADRB3. It may not necessarily be applicable to this product.
 NCBI GI #    4557267
 NCBI GeneID    155
 NCBI Accession #    NP_000016.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000025.2 [Other Products]
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 UniProt Primary Accession #    P13945 [Other Products]
 UniProt Secondary Accession #    Q4JFT4 [Other Products]
 UniProt Related Accession #    P13945 [Other Products]
 Molecular Weight    43519
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 NCBI Official Full Name    beta-3 adrenergic receptor
 NCBI Official Synonym Full Names    adrenoceptor beta 3
 NCBI Official Symbol    ADRB3 [Similar Products]
 NCBI Official Synonym Symbols   
BETA3AR
[Similar Products]
 NCBI Protein Information    beta-3 adrenergic receptor
 UniProt Protein Name    Beta-3 adrenergic receptor
 UniProt Synonym Protein Names   
Beta-3 adrenoreceptor; Beta-3 adrenoceptor
 Protein Family    Beta-3 adrenergic receptor
 UniProt Gene Name    ADRB3 [Similar Products]
 UniProt Synonym Gene Names    ADRB3R; B3AR; Beta-3 adrenoceptor [Similar Products]
 UniProt Entry Name    ADRB3_HUMAN
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 NCBI Summary for ADRB3    The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009]
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 UniProt Comments for ADRB3    ADRB3: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8p12

Cellular Component: integral to plasma membrane; plasma membrane; nucleus; receptor complex

Molecular Function: beta3-adrenergic receptor activity; protein binding; protein homodimerization activity; beta-3 adrenergic receptor binding; norepinephrine binding; epinephrine binding; beta-adrenergic receptor activity

Biological Process: arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; receptor-mediated endocytosis; generation of precursor metabolites and energy; diet induced thermogenesis; negative regulation of multicellular organism growth; eating behavior; adenylate cyclase activation; thermoregulation; response to antibiotic; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to cyclic nucleotide second messenger; cell-cell signaling; positive regulation of MAPKKK cascade; heat generation; carbohydrate metabolic process; brown fat cell differentiation; energy reserve metabolic process; response to cold; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; aging

Disease: Obesity
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Product References and Citations for anti-ADRB3 antibody

   Emorine L.J.,et al.Science 245:1118-1121(1989). van Spronsen A.,et al.Eur. J. Biochem. 213:1117-1124(1993). Lelias J.M.,et al.FEBS Lett. 324:127-130(1993). Kopatz S.A.,et al.Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases. Granneman J.G.,et al.Mol. Pharmacol. 42:964-970(1992).
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 Research Articles on ADRB3    1. in the codominant model Trp/Arg genotype, there was an odds ratio or 1.67 which was increased to 2.56 for the Arg/Arg genotype for association with type 2 diabetes
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADRB3 antibodyPathways associated with anti-ADRB3 antibody
 Reference Product  PubMed Publications
 ADRB2 antibody  >45 publications with ADRB3 and ADRB2
 ADRB1 antibody  >24 publications with ADRB3 and ADRB1
 UCP1 antibody  >12 publications with ADRB3 and UCP1
 POMC antibody  >1 publications with ADRB3 and POMC
 GNAS antibody  >1 publications with ADRB3 and GNAS
 Products by Pathway  Pathway Diagram
 Adrenoceptors Pathway antibodies  Adrenoceptors Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
Diseases associated with anti-ADRB3 antibodyOrgans/Tissues associated with anti-ADRB3 antibody
 Disease Name  Pubmed Publications
 Obesity Antibodies  >89 publications with ADRB3 and Obesity
 Hypertension Antibodies  >20 publications with ADRB3 and Hypertension
 Heart Diseases Antibodies  >12 publications with ADRB3 and Heart Diseases
 Myocardial Ischemia Antibodies  >8 publications with ADRB3 and Myocardial Ischemia
 Necrosis Antibodies  >6 publications with ADRB3 and Necrosis
 Hyperglycemia Antibodies  >5 publications with ADRB3 and Hyperglycemia
 Atherosclerosis Antibodies  >4 publications with ADRB3 and Atherosclerosis
 Myocardial Infarction Antibodies  >4 publications with ADRB3 and Myocardial Infarction
 Heart Failure Antibodies  >4 publications with ADRB3 and Heart Failure
 Inflammation Antibodies  >3 publications with ADRB3 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >6 publications with ADRB3 and Ovary
 Brain Antibodies  >5 publications with ADRB3 and Brain
 Placenta Antibodies  >3 publications with ADRB3 and Placenta
 Mixed Antibodies  >2 publications with ADRB3 and Mixed
 Uterus Antibodies  >2 publications with ADRB3 and Uterus
 Eye Antibodies  >1 publications with ADRB3 and Eye
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