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anti-ADRBK1 antibody :: Rabbit ADRBK1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS127677
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADRBK1, Polyclonal Antibody

★Popular Item★
 Also Known As   

ADRBK1 Polyclonal Antibody

 Product Synonym Names    BARK1; BETA-ARK1; FLJ16718; GRK2
 Product Gene Name   

anti-ADRBK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    109635
 3D Structure    ModBase 3D Structure for P25098
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human ADRBK1
 Calculated Molecular Weight    80kDa
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at -20 degree C (regular). Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-ADRBK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ADRBK1 antibody

   G-protein-coupled receptor kinase 2 (GRK2), also known as beta-adrenergic receptor kinase 1 (beta-ARK1), is a member of the GRK family, which phosphorylates the activated form of G-protein-coupled receptors (GPCRs) and initiates the desensitization process of GPCR (1). GRK2 kinase activity and cellular localization are tightly regulated by interactions with activated receptors, G-beta and G-gamma subunits, adaptor proteins, phospholipids, caveolin and calmodulin, as well as by phosphorylation (1). PKC phosphorylation enhances GRK2 activity by promoting its membrane localization and by abolishing the inhibitory association of calmodulin (2,3). PKA phosphorylates GRK2 at Ser685, which facilitates the association of GRK2 with a beta-adrenergic receptor (4). Erk inhibits GRK2 activity via phosphorylation at Ser670 (5). Src phosphorylates GRK2 at multiple tyrosine residues (Tyr13, 86 and 92), which activates GRK2 activity and promotes GRK2 degradation (6,7).
 Product Categories/Family for anti-ADRBK1 antibody    Polyclonal
 Applications Tested/Suitable for anti-ADRBK1 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ADRBK1 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
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 Western Blot (WB) of anti-ADRBK1 antibody    Western blot analysis of extracts of various cell lines, using ADRBK1 antibody.
anti-ADRBK1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ADRBK1. It may not necessarily be applicable to this product.
 NCBI GI #    126302521
 NCBI GeneID    156
 NCBI Accession #    P25098.2 [Other Products]
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 UniProt Primary Accession #    P25098 [Other Products]
 UniProt Secondary Accession #    Q13837; Q6GTT3; B0ZBE1 [Other Products]
 UniProt Related Accession #    P25098 [Other Products]
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 NCBI Official Full Name    Beta-adrenergic receptor kinase 1
 NCBI Official Synonym Full Names    adrenergic, beta, receptor kinase 1
 NCBI Official Symbol    ADRBK1 [Similar Products]
 NCBI Official Synonym Symbols   
GRK2; BARK1; BETA-ARK1
[Similar Products]
 NCBI Protein Information    beta-adrenergic receptor kinase 1; beta-ARK-1; G-protein coupled receptor kinase 2
 UniProt Protein Name    Beta-adrenergic receptor kinase 1
 UniProt Synonym Protein Names   
G-protein coupled receptor kinase 2
 UniProt Gene Name    ADRBK1 [Similar Products]
 UniProt Synonym Gene Names    BARK; BARK1; GRK2; Beta-ARK-1 [Similar Products]
 UniProt Entry Name    ARBK1_HUMAN
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 NCBI Summary for ADRBK1    The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADRBK1    GRK2: a ubiquitous protein kinase of the GRK family. Phosphorylates the beta-2-adrenergic receptor and related G-protein-coupled receptors. Appears to mediate agonist-specific desensitization observed at high agonist concentrations. Expression level is consistently elevated in chronic human heart failure. Mouse models of severe heart failure have been used to demonstrate that inhibition of BARK1 with a peptide inhibitor is sufficient to increase mean survival, reduce dialation and improve cardiac function.

Protein type: Kinase, protein; EC 2.7.11.15; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; AGC group; GRK family; BARK subfamily

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: membrane; cytoplasm; plasma membrane; cytosol

Molecular Function: G-protein coupled receptor kinase activity; protein binding; Edg-2 lysophosphatidic acid receptor binding; beta-adrenergic receptor kinase activity; alpha-2A adrenergic receptor binding; ATP binding; protein kinase activity

Biological Process: epidermal growth factor receptor signaling pathway; desensitization of G-protein coupled receptor protein signaling pathway; tachykinin signaling pathway; fibroblast growth factor receptor signaling pathway; acetylcholine receptor signaling, muscarinic pathway; nerve growth factor receptor signaling pathway; heart development; peptidyl-threonine phosphorylation; signal transduction; negative regulation of striated muscle contraction; peptidyl-serine phosphorylation; negative regulation of the force of heart contraction by chemical signal; phospholipase C activation; receptor internalization; positive regulation of catecholamine secretion; innate immune response; cardiac muscle contraction
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 Research Articles on ADRBK1    1. Low levels of GRK2/GRK5 causes a slow and not complete desensitization/down-regulation of GPR17.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADRBK1 antibodyPathways associated with anti-ADRBK1 antibody
 Reference Product  PubMed Publications
 ADRB2 antibody  >57 publications with ADRBK1 and ADRB2
 RHO antibody  >11 publications with ADRBK1 and RHO
 GIT1 antibody  >9 publications with ADRBK1 and GIT1
 CXCR4 antibody  >6 publications with ADRBK1 and CXCR4
 CCR5 antibody  >2 publications with ADRBK1 and CCR5
 Products by Pathway  Pathway Diagram
 Activation Of SMO Pathway antibodies  Activation Of SMO Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Ca-dependent Events Pathway antibodies  Ca-dependent Events Pathway Diagram
 CaM Pathway antibodies  CaM Pathway Diagram
 Calmodulin Induced Events Pathway antibodies  Calmodulin Induced Events Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 DAG And IP3 Signaling Pathway antibodies  DAG And IP3 Signaling Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
Diseases associated with anti-ADRBK1 antibodyOrgans/Tissues associated with anti-ADRBK1 antibody
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >100 publications with ADRBK1 and Heart Diseases
 Inflammation Antibodies  >54 publications with ADRBK1 and Inflammation
 Hypertension Antibodies  >44 publications with ADRBK1 and Hypertension
 Myocardial Ischemia Antibodies  >35 publications with ADRBK1 and Myocardial Ischemia
 Pain Antibodies  >28 publications with ADRBK1 and Pain
 Myocardial Infarction Antibodies  >27 publications with ADRBK1 and Myocardial Infarction
 Cardiomegaly Antibodies  >16 publications with ADRBK1 and Cardiomegaly
 Cardiomyopathies Antibodies  >14 publications with ADRBK1 and Cardiomyopathies
 Postoperative Complications Antibodies  >13 publications with ADRBK1 and Postoperative Complications
 Necrosis Antibodies  >12 publications with ADRBK1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >123 publications with ADRBK1 and Muscle
 Blood Antibodies  >114 publications with ADRBK1 and Blood
 Brain Antibodies  >99 publications with ADRBK1 and Brain
 Kidney Antibodies  >66 publications with ADRBK1 and Kidney
 Vascular Antibodies  >66 publications with ADRBK1 and Vascular
 Nerve Antibodies  >24 publications with ADRBK1 and Nerve
 Lung Antibodies  >15 publications with ADRBK1 and Lung
 Bone Antibodies  >15 publications with ADRBK1 and Bone
 Liver Antibodies  >14 publications with ADRBK1 and Liver
 Embryonic Tissue Antibodies  >13 publications with ADRBK1 and Embryonic Tissue
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