Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow ADRBK1 rightarrow Polyclonal ADRBK1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • SKIV2L2 Antibody
 • CD33 Antibody
 • BRAF V600E Antibody
 • hGH Antibody
 • DARPP32 Antibody
 • Probable sucrose-phosphate synthase 2 (SPS2) Recombinant Protein
 • Dyslexia-Associated Protein KIAA0319-Like Protein (KIAA0319L... ELISA Kit
 • Prostate Specific Antigen (PSA) ACT Complex >95% Pure (KLK3) Native Protein
 • MAP2K6 Antibody
 • IGF-I Recombinant Protein
 • 27 OHC (27-Hydroxycholesterol) ELISA Kit
 • hydroxysteroid (17-beta) dehydrogenase 4 (HSD17B4) Antibody
 • HLAABC Antibody
 • Poly [ADP-ribose] polymerase 1 (Parp1) Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-ADRBK1 antibody :: Rabbit anti-Human ADRBK1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2526542
Testing Data
Unit / Price
0.06 mL  /  $195 +1 FREE 8GB USB
0.12 mL  /  $270 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADRBK1, Polyclonal Antibody

 Also Known As   

ADRBK1 Antibody

 Product Synonym Names    BARK1; BETA-ARK1; FLJ16718; GRK2
 Product Gene Name   

anti-ADRBK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    109635
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Section Bar
 Purity/Purification    Antigen affinity purification
Section Bar
 Immunogen    Fusion protein of ADRBK1
 Calculated Molecular Weight: 689aa; 80kd
Observed Molecular Weight: 80kd
  
 Buffer    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-18409 / sc-562 / sc-8329
Section Bar
 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ADRBK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-ADRBK1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ADRBK1 antibody    WB: 1:500-1:5000
IHC: 1:50-1:200
Section Bar
 Testing Data of anti-ADRBK1 antibody    anti-ADRBK1 antibody Testing Data image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for ADRBK1. It may not necessarily be applicable to this product.
 NCBI GI #    60552563
 NCBI GeneID    156
 NCBI Accession #    AAH90863.1 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q13837; Q6GTT3; B0ZBE1 [Other Products]
 UniProt Related Accession #    P25098 [Other Products]
 Molecular Weight    79,574 Da
Table BarTOPTable Bar
 NCBI Official Full Name    ADRBK1 protein
 NCBI Official Synonym Full Names    adrenergic, beta, receptor kinase 1
 NCBI Official Symbol    ADRBK1 [Similar Products]
 NCBI Official Synonym Symbols   
GRK2; BARK1; BETA-ARK1
[Similar Products]
 NCBI Protein Information    beta-adrenergic receptor kinase 1; G-protein coupled receptor kinase 2; beta-ARK-1
 UniProt Protein Name    Beta-adrenergic receptor kinase 1
 UniProt Synonym Protein Names   
G-protein coupled receptor kinase 2
 UniProt Gene Name    ADRBK1 [Similar Products]
 UniProt Synonym Gene Names    BARK; BARK1; GRK2; Beta-ARK-1 [Similar Products]
 UniProt Entry Name    ARBK1_HUMAN
Section Bar
 NCBI Summary for ADRBK1    The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for ADRBK1    GRK2: a ubiquitous protein kinase of the GRK family. Phosphorylates the beta-2-adrenergic receptor and related G-protein-coupled receptors. Appears to mediate agonist-specific desensitization observed at high agonist concentrations. Expression level is consistently elevated in chronic human heart failure. Mouse models of severe heart failure have been used to demonstrate that inhibition of BARK1 with a peptide inhibitor is sufficient to increase mean survival, reduce dialation and improve cardiac function.

Protein type: EC 2.7.11.15; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; AGC group; GRK family; BARK subfamily

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: membrane; cytoplasm; plasma membrane; cytosol

Molecular Function: G-protein coupled receptor kinase activity; protein binding; beta-adrenergic receptor kinase activity; Edg-2 lysophosphatidic acid receptor binding; alpha-2A adrenergic receptor binding; ATP binding; protein kinase activity

Biological Process: epidermal growth factor receptor signaling pathway; tachykinin signaling pathway; desensitization of G-protein coupled receptor protein signaling pathway; fibroblast growth factor receptor signaling pathway; acetylcholine receptor signaling, muscarinic pathway; nerve growth factor receptor signaling pathway; heart development; peptidyl-threonine phosphorylation; signal transduction; negative regulation of striated muscle contraction; peptidyl-serine phosphorylation; negative regulation of the force of heart contraction by chemical signal; phospholipase C activation; receptor internalization; innate immune response; positive regulation of catecholamine secretion; cardiac muscle contraction
Table BarTOPTable Bar
 Research Articles on ADRBK1    1. Data indicate that residues on the G-protein coupled receptor kinase 2 (GRK2) N terminus and kinase domain extension collaborate to create a G protein-coupled receptor (GPCR) docking site.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-ADRBK1 antibodyPathways associated with anti-ADRBK1 antibody
 Reference Product  PubMed Publications
 ADRB2 antibody  >57 publications with ADRBK1 and ADRB2
 RHO antibody  >11 publications with ADRBK1 and RHO
 GIT1 antibody  >9 publications with ADRBK1 and GIT1
 CXCR4 antibody  >6 publications with ADRBK1 and CXCR4
 CCR5 antibody  >2 publications with ADRBK1 and CCR5
 Products by Pathway  Pathway Diagram
 Activation Of SMO Pathway antibodies  Activation Of SMO Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Ca-dependent Events Pathway antibodies  Ca-dependent Events Pathway Diagram
 CaM Pathway antibodies  CaM Pathway Diagram
 Calmodulin Induced Events Pathway antibodies  Calmodulin Induced Events Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 DAG And IP3 Signaling Pathway antibodies  DAG And IP3 Signaling Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
Diseases associated with anti-ADRBK1 antibodyOrgans/Tissues associated with anti-ADRBK1 antibody
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >102 publications with ADRBK1 and Heart Diseases
 Inflammation Antibodies  >55 publications with ADRBK1 and Inflammation
 Hypertension Antibodies  >45 publications with ADRBK1 and Hypertension
 Myocardial Ischemia Antibodies  >35 publications with ADRBK1 and Myocardial Ischemia
 Pain Antibodies  >28 publications with ADRBK1 and Pain
 Myocardial Infarction Antibodies  >27 publications with ADRBK1 and Myocardial Infarction
 Cardiomegaly Antibodies  >16 publications with ADRBK1 and Cardiomegaly
 Cardiomyopathies Antibodies  >14 publications with ADRBK1 and Cardiomyopathies
 Ventricular Dysfunction Antibodies  >13 publications with ADRBK1 and Ventricular Dysfunction
 Postoperative Complications Antibodies  >13 publications with ADRBK1 and Postoperative Complications
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >127 publications with ADRBK1 and Muscle
 Blood Antibodies  >115 publications with ADRBK1 and Blood
 Brain Antibodies  >99 publications with ADRBK1 and Brain
 Vascular Antibodies  >67 publications with ADRBK1 and Vascular
 Kidney Antibodies  >66 publications with ADRBK1 and Kidney
 Nerve Antibodies  >24 publications with ADRBK1 and Nerve
 Lung Antibodies  >16 publications with ADRBK1 and Lung
 Bone Antibodies  >15 publications with ADRBK1 and Bone
 Liver Antibodies  >14 publications with ADRBK1 and Liver
 Embryonic Tissue Antibodies  >14 publications with ADRBK1 and Embryonic Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions