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anti-AES antibody :: Rabbit AES Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150968
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AES, Polyclonal Antibody

 Also Known As   

AES Antibody

 Product Synonym Names    AES; GRG; ESP1; GRG5; TLE5; AES-1; AES-2; GRG; Amino-terminal enhancer of split; Gp130-associated protein GAM; Amino enhancer of split; amino-terminal enhancer of split
 Product Gene Name   

anti-AES antibody

[Similar Products]
 Antibody/Peptide Pairs    AES peptide (MBS152200) is used for blocking the activity of AES antibody (MBS150968)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600188
 3D Structure    ModBase 3D Structure for Q08117
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    AES Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    AES antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human AES.
 Buffer    AES Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    AES antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-AES antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-AES antibody

   AES Antibody: Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis. It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family. Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin.
 Applications Tested/Suitable for anti-AES antibody   

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-AES antibody    AES antibody can be used for the detection of AES by Western blot at 1 - 4 mug/mL. Antibody can also be used for immunocytochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-AES antibody    Western blot analysis of AES in 293 cell lysate with AES antibody at (A) 1, (B) 2 and (C) 4 μg/mL.
anti-AES antibody Western Blot (WB) (WB) image
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 Immunocytochemistry (ICC) of anti-AES antibody    Immunocytochemistry of AES in HeLa cells with AES antibody at 10 μg/mL.
anti-AES antibody Immunocytochemistry (ICC) (ICC) image
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 Immunofluorescence (IF) of anti-AES antibody    Immunofluorescence of AES in Hela cells with AES antibody at 20 μg/mL.
anti-AES antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for AES. It may not necessarily be applicable to this product.
 NCBI GI #    39812019
 NCBI GeneID    166
 NCBI Accession #    NP_945320 [Other Products]
 NCBI GenBank Nucleotide #    NM_198969.1 [Other Products]
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 UniProt Primary Accession #    Q08117 [Other Products]
 UniProt Secondary Accession #    Q12808; Q14CJ1; Q96TG9; Q9UDY9; B2RBL0 [Other Products]
 UniProt Related Accession #    Q08117 [Other Products]
 Molecular Weight    29,091 Da
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 NCBI Official Full Name    amino-terminal enhancer of split isoform a
 NCBI Official Synonym Full Names    amino-terminal enhancer of split
 NCBI Official Symbol    AES [Similar Products]
 NCBI Official Synonym Symbols   
GRG; ESP1; GRG5; TLE5; AES-1; AES-2; Grg-5
[Similar Products]
 NCBI Protein Information    amino-terminal enhancer of split; groucho-related protein 5; gp130-associated protein GAM
 UniProt Protein Name    Amino-terminal enhancer of split
 UniProt Synonym Protein Names   
Gp130-associated protein GAM; Grg-5; Groucho-related protein 5; Protein ESP1; Protein GRG
 Protein Family    Acetyl esterase
 UniProt Gene Name    AES [Similar Products]
 UniProt Synonym Gene Names    GRG; GRG5; Amino enhancer of split [Similar Products]
 UniProt Entry Name    AES_HUMAN
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 NCBI Summary for AES    The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AES    AES: Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Belongs to the WD repeat Groucho/TLE family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleus

Molecular Function: protein binding; transcription corepressor activity

Biological Process: organ morphogenesis; Wnt receptor signaling pathway; transcription, DNA-dependent; regulation of growth; multicellular organismal development; cellular response to extracellular stimulus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of protein binding; negative regulation of transcription, DNA-dependent; skeletal development
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 Research Articles on AES    1. AES binds to PROP1 and represses its expression; PROP1 mutation is a likely cause of combined pituitary hormone deficiency.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AES antibodyPathways associated with anti-AES antibody
 Reference Product  PubMed Publications
 TLE1 antibody  >16 publications with AES and TLE1
 CTNNB1 antibody  >9 publications with AES and CTNNB1
 CCND1 antibody  >5 publications with AES and CCND1
 SIX3 antibody  >2 publications with AES and SIX3
 MYC antibody  >2 publications with AES and MYC
 HDAC1 antibody  >1 publications with AES and HDAC1
 LEF1 antibody  >1 publications with AES and LEF1
 HNF1A antibody  >1 publications with AES and HNF1A
 Products by Pathway  Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway antibodies  APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
 AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway antibodies  AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Degradation Of Beta-catenin By The Destruction Complex Pathway antibodies  Degradation Of Beta-catenin By The Destruction Complex Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Presenilin Action In Notch And Wnt Signaling Pathway antibodies  Presenilin Action In Notch And Wnt Signaling Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
Diseases associated with anti-AES antibodyOrgans/Tissues associated with anti-AES antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >455 publications with AES and Brain Diseases
 Cardiovascular Diseases Antibodies  >450 publications with AES and Cardiovascular Diseases
 Hypertension Antibodies  >332 publications with AES and Hypertension
 Drug-Related Side Effects and Adverse Reactions Antibodies  >284 publications with AES and Drug-Related Side Effects and Adverse Reactions
 Liver Diseases Antibodies  >205 publications with AES and Liver Diseases
 Heart Diseases Antibodies  >169 publications with AES and Heart Diseases
 Kidney Diseases Antibodies  >154 publications with AES and Kidney Diseases
 Edema Antibodies  >145 publications with AES and Edema
 Inflammation Antibodies  >117 publications with AES and Inflammation
 Neoplasm Metastasis Antibodies  >110 publications with AES and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1416 publications with AES and Blood
 Liver Antibodies  >395 publications with AES and Liver
 Skin Antibodies  >379 publications with AES and Skin
 Lung Antibodies  >309 publications with AES and Lung
 Bone Antibodies  >291 publications with AES and Bone
 Heart Antibodies  >286 publications with AES and Heart
 Brain Antibodies  >271 publications with AES and Brain
 Kidney Antibodies  >243 publications with AES and Kidney
 Vascular Antibodies  >227 publications with AES and Vascular
 Muscle Antibodies  >187 publications with AES and Muscle
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