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anti-AFAP1L1 antibody :: Rabbit anti-Human, Mouse AFAP1L Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150104
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AFAP1L (AFAP1L1), Polyclonal Antibody

 Also Known As   

AFAP1L Antibody

 Product Synonym Names    AFAP1L; Actin filament-associated protein 1-like 1; AFAP1-like protein 1; actin filament associated protein 1-like 1
 Product Gene Name   

anti-AFAP1L1 antibody

[Similar Products]
 Antibody/Peptide Pairs    AFAP1L1 peptide (MBS152864) is used for blocking the activity of AFAP1L antibody (MBS150104)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    614410
 3D Structure    ModBase 3D Structure for Q8TED9
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    At least four isoforms of AFAP1L1 are known to exist. This antibody is predicted to not cross-react with other AFAP family members.
 Purity/Purification    AFAP1L Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    AFAP1L1 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human AFAP1L1.
 Buffer    AFAP1L Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    AFAP1L antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-AFAP1L1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-AFAP1L1 antibody

   AFAP1L Antibody: The actin filament-associated protein 1 (AFAP1)-like 1 protein is one of three members in the AFAP1 family of adaptor proteins. Like AFAP1, AFAP1L1 is an actin binding protein that has a role in actin cytoskeleton arrangement, but AFAP1L1 is thought to have a unique function distinct from AFAP1. AFAP1L1 colocalizes with cortactin and localizes to invadosomes, highly dynamic, actin-rich adhesion structures harboring metalloproteases, suggesting that AFAP1L1 affects invadosome formation (1, 4). Recent reports suggest that AFAP1L1 can be used as a prognostic marker for spindle cell sarcomas.
 Applications Tested/Suitable for anti-AFAP1L1 antibody   

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-AFAP1L1 antibody    AFAP1L1 antibody can be used for detection of AFAP1L1 by Western blot at 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-AFAP1L1 antibody    Western blot analysis of AFAP1L1 in A549 cell lysate with AFAP1L1 antibody at 1 μg/mL.
anti-AFAP1L1 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-AFAP1L1 antibody    Immunofluorescence of AFAP1L in A549 cells with AFAP1L antibody at 20 μg/mL.
anti-AFAP1L1 antibody Immunofluorescence (IF) image
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 Immunocytochemistry (ICC) of anti-AFAP1L1 antibody    Immunocytochemistry of AFAP1L in A549 cells with AFAP1L antibody at 5 μg/mL.
anti-AFAP1L1 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for AFAP1L1. It may not necessarily be applicable to this product.
 NCBI GI #    55742689
 NCBI GeneID    134265
 NCBI Accession #    NP_689619 [Other Products]
 NCBI GenBank Nucleotide #    NM_152406.2 [Other Products]
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 UniProt Primary Accession #    Q8TED9 [Other Products]
 UniProt Secondary Accession #    Q08AN4; Q08AN5; Q8IW82; Q8N8Z5; Q8N9Q4 [Other Products]
 UniProt Related Accession #    Q8TED9 [Other Products]
 Molecular Weight    43,455 Da
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 NCBI Official Full Name    actin filament-associated protein 1-like 1 isoform 1
 NCBI Official Synonym Full Names    actin filament associated protein 1-like 1
 NCBI Official Symbol    AFAP1L1 [Similar Products]
 NCBI Protein Information    actin filament-associated protein 1-like 1; AFAP1-like protein 1
 UniProt Protein Name    Actin filament-associated protein 1-like 1
 Protein Family    Actin filament-associated protein
 UniProt Gene Name    AFAP1L1 [Similar Products]
 UniProt Synonym Gene Names    AFAP1-like protein 1 [Similar Products]
 UniProt Entry Name    AF1L1_HUMAN
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 UniProt Comments for AFAP1L1    AFAP1L1: a protein containing two pleckstrin homology (PH) domains, which mediate protein-protein and protein-lipid interactions.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: cytoplasm; plasma membrane; podosome; cell junction; nucleus
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 Research Articles on AFAP1L1    1. Findings indicate a role for transcription factor Sp3 in sarcomas as a driver for expression of the metastasis-related gene AFAP1L1 (actin filament-associated protein 1-like 1).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-AFAP1L1 antibodyOrgans/Tissues associated with anti-AFAP1L1 antibody
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >2 publications with AFAP1L1 and Neoplasm Metastasis
 Neurobehavioral Manifestations Antibodies  >1 publications with AFAP1L1 and Neurobehavioral Manifestations
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >1 publications with AFAP1L1 and Lymph Node
 Muscle Antibodies  >1 publications with AFAP1L1 and Muscle
 Vascular Antibodies  >1 publications with AFAP1L1 and Vascular
 Heart Antibodies  >1 publications with AFAP1L1 and Heart
 Brain Antibodies  >1 publications with AFAP1L1 and Brain
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