NP_001116244.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
90,537 Da
NCBI Official Full Name
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform PIKE-L
NCBI Official Synonym Full Names
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
NCBI Protein Information
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
UniProt Protein Name
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
UniProt Synonym Protein Names
Centaurin-gamma-1; Cnt-g1; GTP-binding and GTPase-activating protein 2; GGAP2; Phosphatidylinositol 3-kinase enhancer; PIKE
UniProt Synonym Gene Names
NCBI Summary for AGAP2
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
UniProt Comments for AGAP2
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
Product References and Citations for anti-AGAP2 antibody
(1) Shiba, Y., Romer, W., Mardones, G.A., . AGAP2 regulates retrograde transport between early endosomes and the TGN. J. Cell. Sci. 123 (PT 14), 2381-2390 (2010).
Research Articles on AGAP2
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Products associated with anti-AGAP2 antibody
Pathways associated with anti-AGAP2 antibody
Diseases associated with anti-AGAP2 antibody
Organs/Tissues associated with anti-AGAP2 antibody
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