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anti-GATM antibody :: AGAT Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8245218
Unit / Price
0.05 mL  /  $195 +1 FREE 8GB USB
0.1 mL  /  $250 +1 FREE 8GB USB
0.2 mL  /  $350 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AGAT (GATM), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-AGAT Antibody

 Product Synonym Names    AGAT; Glycine amidinotransferase, mitochondrial; L-arginine:glycine amidinotransferase; Transamidinase
 Product Gene Name   

anti-GATM antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602360
 3D Structure    ModBase 3D Structure for P50440
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 Clonality    Polyclonal
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes endogenous levels of AGAT protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Source    Rabbit
 Immunogen    Recombinant full length protein of human AGAT
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-GATM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GATM antibody

   Rabbit polyclonal antibody to AGAT
 Applications Tested/Suitable for anti-GATM antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

 Application Notes for anti-GATM antibody    WB: 1/500 - 1/2000; IHC: 1/50 - 1/200; IF/ICC: 1/50 - 1/200
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 Western Blot (WB) of anti-GATM antibody    Western blot analysis of AGAT expression in mouse kidney (A), rat kidney (B) whole cell lysates.
anti-GATM antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-GATM antibody    Immunohistochemical analysis of AGAT staining in mouse kidney formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-GATM antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-GATM antibody    Immunofluorescent analysis of AGAT staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 degree C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
anti-GATM antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for GATM. It may not necessarily be applicable to this product.
 NCBI GI #    4503933
 NCBI GeneID    2628
 NCBI Accession #    NP_001473.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001482.2 [Other Products]
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 UniProt Primary Accession #    P50440 [Other Products]
 UniProt Secondary Accession #    Q53EQ4; B4DH99; B4DPI3 [Other Products]
 UniProt Related Accession #    P50440 [Other Products]
 Molecular Weight    44,943 Da
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 NCBI Official Full Name    glycine amidinotransferase, mitochondrial isoform 1
 NCBI Official Synonym Full Names    glycine amidinotransferase
 NCBI Official Symbol    GATM [Similar Products]
 NCBI Official Synonym Symbols   
AT; AGAT; CCDS3
[Similar Products]
 NCBI Protein Information    glycine amidinotransferase, mitochondrial
 UniProt Protein Name    Glycine amidinotransferase, mitochondrial
 UniProt Synonym Protein Names   
L-arginine:glycine amidinotransferase; Transamidinase
 Protein Family    Glycine amidinotransferase
 UniProt Gene Name    GATM [Similar Products]
 UniProt Synonym Gene Names    AGAT [Similar Products]
 UniProt Entry Name    GATM_HUMAN
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 NCBI Summary for GATM    This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by mental retardation, language impairment, and behavioral disorders. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GATM    GATM: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis. Defects in GATM are the cause of arginine:glycine amidinotransferase deficiency (AGAT deficiency). AGAT deficiency is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of expressive and cognitive speech, and severe depletion of creatine/phosphocreatine in the brain. Belongs to the amidinotransferase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; Amino Acid Metabolism - arginine and proline; Mitochondrial; EC 2.1.4.1; Amino Acid Metabolism - glycine, serine and threonine

Chromosomal Location of Human Ortholog: 15q21.1

Cellular Component: mitochondrial inner membrane; mitochondrial intermembrane space

Molecular Function: glycine amidinotransferase activity

Biological Process: creatine biosynthetic process; creatine metabolic process

Disease: Cerebral Creatine Deficiency Syndrome 3
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 Research Articles on GATM    1. Meta-analysis yielded a marginal, but null, association of GATM rs9806699 with statin-induced myopathy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-GATM antibodyDiseases associated with anti-GATM antibody
 Products by Pathway  Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Creatine Metabolism Pathway antibodies  Creatine Metabolism Pathway Diagram
 Creatine Pathway antibodies  Creatine Pathway Diagram
 Creatine Pathway antibodies  Creatine Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >10 publications with GATM and Nervous System Diseases
 Arginine:Glycine Amidinotransferase Deficiency Antibodies  >7 publications with GATM and Arginine:Glycine Amidinotransferase Deficiency
 Inflammation Antibodies  >4 publications with GATM and Inflammation
 Brain Diseases Antibodies  >3 publications with GATM and Brain Diseases
 Kidney Diseases Antibodies  >3 publications with GATM and Kidney Diseases
 Lung Neoplasms Antibodies  >2 publications with GATM and Lung Neoplasms
 Lung Diseases Antibodies  >2 publications with GATM and Lung Diseases
 Neurobehavioral Manifestations Antibodies  >1 publications with GATM and Neurobehavioral Manifestations
 Disease Models, Animal Antibodies  >1 publications with GATM and Disease Models, Animal
 Carcinoma Antibodies  >1 publications with GATM and Carcinoma
Organs/Tissues associated with anti-GATM antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >8 publications with GATM and Kidney
 Brain Antibodies  >8 publications with GATM and Brain
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