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anti-AGTR1 antibody :: anti-Human, Mouse AGTR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS178133
Unit / Price
0.1 mg  /  $280 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AGTR1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-AGTR1 Antibody

 Product Synonym Names    Type-1 angiotensin II receptor; AG2S; Agtr 1; Agtr1; AGTR1_HUMAN; Agtr1a; AGTR1B; Ang II; Angiotensin II receptor type 1; Angiotensin II type-1 receptor; Angiotensin receptor 1; Angiotensin receptor 1B; AT 1B; AT 1r; AT1; At1a; AT1AR; AT1B; AT1BR; AT1R; AT2R1; AT2R1A; AT2R1B; HAT1R; Type 1 angiotensin II receptor; Type 1B angiotensin II receptor; Type-1 angiotensin II receptor; angiotensin II receptor, type 1
 Product Gene Name   

anti-AGTR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    106165
 3D Structure    ModBase 3D Structure for P30556
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 Clonality    Polyclonal
 Species Reactivity    Human, Mouse
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 Specificity    No cross reactivity with other protiens.
 Purity/Purification    Immunogen Affinity Purified
 Form/Format    Lyophilized
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 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
 Immunogen    A synthetic peptide corresponding to a sequence at the N-terminus of human AGTR1 (1-28aa MILNSSTEDGIKRIQDDCPKAGRHNYIF), different from the related mouse and rat sequences by one amino acid.
 Ig Type    Rabbit IgG
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquoted and stored frozen at -20C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-AGTR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-AGTR1 antibody

   Description: Rabbit IgG polyclonal antibody for Type-1 angiotensin II receptor(AGTR1) detection. Tested with WB, IHC-P in Human;Mouse.

Background: AGTR1 is known as Angiotensin II Type 1 Receptor. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. And it acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. Moreover, this gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene.
 Applications Tested/Suitable for anti-AGTR1 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-AGTR1 antibody    Western Blot
Concentration: 0.1-0.5ug/ml
Tested Species: Hu, Ms


Immunohistochemistry (IHC) Paraffin:
Concentration: 0.5-1ug/ml
Tested Species: Hu
Antigen Retrieval: By Heat

Tested Species: In-house tested species with positive results.
By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Other applications have not been tested.
Optimal dilutions shold be determined by end users.
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 Western Blot (WB) of anti-AGTR1 antibody    Anti- AGTR1 Picoband antibody, MBS178133, Western blotting
All lanes: Anti AGTR1 (MBS178133) at 0.5ug/ml
Lane 1: HELA Whole Cell Lysate at 40ug
Lane 2: HEPA Whole Cell Lysate at 40ug
Predicted bind size: 47KD
Observed bind size: 47KD
anti-AGTR1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-AGTR1 antibody    Anti- AGTR1 Picoband antibody, MBS178133, IHC(P)
IHC(P): Human Mammary Cancer Tissue
anti-AGTR1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for AGTR1. It may not necessarily be applicable to this product.
 NCBI GI #    4501997
 NCBI GeneID    185
 NCBI Accession #    NP_000676.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000685.4 [Other Products]
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 UniProt Primary Accession #    P30556 [Other Products]
 UniProt Secondary Accession #    Q13725; Q8TBK4 [Other Products]
 UniProt Related Accession #    P30556 [Other Products]
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 NCBI Official Full Name    type-1 angiotensin II receptor isoform 1
 NCBI Official Synonym Full Names    angiotensin II receptor type 1
 NCBI Official Symbol    AGTR1 [Similar Products]
 NCBI Official Synonym Symbols   
AT1; AG2S; AT1B; AT1R; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1B
[Similar Products]
 NCBI Protein Information    type-1 angiotensin II receptor
 UniProt Protein Name    Type-1 angiotensin II receptor
 UniProt Synonym Protein Names   
AT1AR; AT1BR; Angiotensin II type-1 receptor; AT1
 Protein Family    Type-1 angiotensin II receptor
 UniProt Gene Name    AGTR1 [Similar Products]
 UniProt Synonym Gene Names    AGTR1A; AGTR1B; AT2R1; AT2R1B; AT1 [Similar Products]
 UniProt Entry Name    AGTR1_HUMAN
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 NCBI Summary for AGTR1    Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
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 UniProt Comments for AGTR1    AT1: receptor for angiotensin II. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. Mediates the major cardiovascular effects of angiotensin II. May play role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3q24

Cellular Component: integral to membrane; integral to plasma membrane; intracellular; plasma membrane

Molecular Function: angiotensin type I receptor activity; angiotensin type II receptor activity; bradykinin receptor binding; protein binding; protein heterodimerization activity

Biological Process: calcium-mediated signaling; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); kidney development; positive regulation of cellular protein metabolic process; positive regulation of inflammatory response; positive regulation of NAD(P)H oxidase activity; positive regulation of phospholipase A2 activity; regulation of cell growth; regulation of cell proliferation; regulation of inflammatory response; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of vasoconstriction; regulation of vasodilation; renin-angiotensin regulation of aldosterone production; renin-angiotensin regulation of blood vessel size; Rho protein signal transduction

Disease: Hypertension, Essential; Renal Tubular Dysgenesis
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Product References and Citations for anti-AGTR1 antibody

   1. "Entrez Gene: AGTR1 angiotensin II receptor, type 1". 2. Catt KJ, Mendelsohn FA, Millan MA, Aguilera G (1984). "The role of angiotensin II receptors in vascular regulation". J. Cardiovasc. Pharmacol. 6(Suppl 4): S575-86. 3. Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S (2007). "Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology". Clin. Sci. 112 (8): 417-28.
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 Research Articles on AGTR1    1. CC AT1R genotype was associated with deteriorated endothelial functions in the target vessels of PCI and intermediate to long-term in-stent restenosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AGTR1 antibodyPathways associated with anti-AGTR1 antibody
 Reference Product  PubMed Publications
 AGT antibody  >133 publications with AGTR1 and AGT
 NOS3 antibody  >21 publications with AGTR1 and NOS3
 ACE2 antibody  >19 publications with AGTR1 and ACE2
 BDKRB2 antibody  >7 publications with AGTR1 and BDKRB2
 JAK2 antibody  >1 publications with AGTR1 and JAK2
 KNG1 antibody  >1 publications with AGTR1 and KNG1
 GRK5 antibody  >1 publications with AGTR1 and GRK5
 Products by Pathway  Pathway Diagram
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 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
Diseases associated with anti-AGTR1 antibodyOrgans/Tissues associated with anti-AGTR1 antibody
 Disease Name  Pubmed Publications
 Vascular Diseases Antibodies  >138 publications with AGTR1 and Vascular Diseases
 Hypertension Antibodies  >123 publications with AGTR1 and Hypertension
 Heart Diseases Antibodies  >79 publications with AGTR1 and Heart Diseases
 Kidney Diseases Antibodies  >44 publications with AGTR1 and Kidney Diseases
 Atherosclerosis Antibodies  >28 publications with AGTR1 and Atherosclerosis
 Inflammation Antibodies  >28 publications with AGTR1 and Inflammation
 Hypertrophy Antibodies  >22 publications with AGTR1 and Hypertrophy
 Heart Failure Antibodies  >18 publications with AGTR1 and Heart Failure
 Diabetic Nephropathies Antibodies  >18 publications with AGTR1 and Diabetic Nephropathies
 Myocardial Infarction Antibodies  >16 publications with AGTR1 and Myocardial Infarction
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >67 publications with AGTR1 and Heart
 Kidney Antibodies  >46 publications with AGTR1 and Kidney
 Muscle Antibodies  >31 publications with AGTR1 and Muscle
 Brain Antibodies  >19 publications with AGTR1 and Brain
 Lung Antibodies  >15 publications with AGTR1 and Lung
 Placenta Antibodies  >15 publications with AGTR1 and Placenta
 Liver Antibodies  >13 publications with AGTR1 and Liver
 Connective Tissue Antibodies  >9 publications with AGTR1 and Connective Tissue
 Embryonic Tissue Antibodies  >8 publications with AGTR1 and Embryonic Tissue
 Intestine Antibodies  >5 publications with AGTR1 and Intestine
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