NP_005152.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
apelin receptor
NCBI Official Synonym Full Names
apelin receptor
NCBI Protein Information
apelin receptor
UniProt Protein Name
Apelin receptor
UniProt Synonym Protein Names
Angiotensin receptor-like 1; G-protein coupled receptor APJ; G-protein coupled receptor HG11
UniProt Synonym Gene Names
NCBI Summary for AGTRL1
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]
UniProt Comments for AGTRL1
Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11090199, PubMed:25639753, PubMed:28137936). Plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone (). Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility, and heart failure by acting as a receptor for APLN hormone (PubMed:25639753, PubMed:28137936).
Research Articles on AGTRL1
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Products associated with anti-AGTRL1 antibody
Pathways associated with anti-AGTRL1 antibody
Diseases associated with anti-AGTRL1 antibody
Organs/Tissues associated with anti-AGTRL1 antibody
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