AAI32820.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,010 Da
NCBI Official Full Name
Alanine-glyoxylate aminotransferase
NCBI Official Synonym Full Names
alanine-glyoxylate aminotransferase
NCBI Official Synonym Symbols
AGT; PH1; SPT; AGT1; SPAT; TLH6; AGXT1 [Similar Products]
NCBI Protein Information
serine--pyruvate aminotransferase
UniProt Protein Name
Serine--pyruvate aminotransferase
UniProt Synonym Protein Names
Alanine--glyoxylate aminotransferase (EC:2.6.1.44); AGT
UniProt Synonym Gene Names
NCBI Summary for AGXT
This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008]
UniProt Comments for AGXT
AGXT: Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1); also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - glycine, serine and threonine; EC 2.6.1.44; EC 2.6.1.51; Mitochondrial; Motility/polarity/chemotaxis; Transferase
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: peroxisomal matrix; peroxisome
Molecular Function: alanine-glyoxylate transaminase activity; amino acid binding; protein binding; protein homodimerization activity; protein self-association; pyridoxal phosphate binding; receptor binding; serine-pyruvate transaminase activity; transaminase activity
Biological Process: glycine biosynthetic process, by transamination of glyoxylate; glyoxylate catabolic process; glyoxylate metabolic process; L-alanine catabolic process; L-cysteine catabolic process; proteasomal protein catabolic process
Disease: Hyperoxaluria, Primary, Type I
Research Articles on AGXT
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Products associated with anti-AGXT antibody
Pathways associated with anti-AGXT antibody
Diseases associated with anti-AGXT antibody
Organs/Tissues associated with anti-AGXT antibody
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