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anti-AHI1 antibody :: Rabbit anti-Human AHI1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS852881
Testing Data
Unit / Price
0.1 mg  /  $330 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AHI1, Polyclonal Antibody

 Also Known As   

AHI1 Antibody

 Product Gene Name   

anti-AHI1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608894
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Lyophilized anti-AHI1 antibody purified by peptide affinity column containing 1% BSA and 0.02% NaN3
 Concentration    100ug/200ul (lot specific)
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 Source Note    Rabbit polyclonal AHI1 (1) antibody was raised against a peptide from N terminal residues of human AHI1 protein.
 Reactivity Note    Not yet tested in other species.
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 Other Notes    Small volumes of anti-AHI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-AHI1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-AHI1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-AHI1 antibody    Peptide ELISA titer: 1:10,000-1:40,000
Western blot analysis: 1:1,000-1:2,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user.
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 Testing Data of anti-AHI1 antibody    anti-AHI1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for AHI1. It may not necessarily be applicable to this product.
 NCBI GI #    68989463
 NCBI Accession #    AAY99645.1 [Other Products]
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 UniProt Secondary Accession #    Q4FD35; Q504T3; Q5TCP9; Q6P098; Q6PIT6; Q8NDX0; Q9H0H2; E1P584 [Other Products]
 Molecular Weight    70,047 Da
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 NCBI Official Full Name    AHI1
 UniProt Protein Name    Jouberin
 UniProt Synonym Protein Names   
Abelson helper integration site 1 protein homolog; AHI-1
 Protein Family    Jouberin
 UniProt Gene Name    AHI1 [Similar Products]
 UniProt Synonym Gene Names    AHI-1 [Similar Products]
 UniProt Entry Name    AHI1_HUMAN
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 UniProt Comments for AHI1    AHI1: is up-regulated at all stages of chronic myeloid leukemia (CML). Down-regulated during early differentiation of normal hematopoietic cells. The AHI-1 gene is activated by insertional mutagenesis in mouse models of leukemia. Important for cerebellar and cortical development, and axonal decussation. Mutations of the AHI-1 gene are associated with Joubert syndrome. Highly expressed in the most primitive normal hematopoietic cells. Expressed in brain, particularly in neurons that give rise to the crossing axons of the corticospinal tract and superior cerebellar peduncles. Genetic analysis indicates that it is important in the development of human-specific motor behaviors. Three alternatively spliced isoforms have been described.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 6q23.3

Cellular Component: centriole; centrosome; photoreceptor outer segment; adherens junction; nonmotile primary cilium; intercellular junction; cilium

Molecular Function: identical protein binding; protein binding

Biological Process: positive regulation of polarized epithelial cell differentiation; central nervous system development; vesicle targeting; positive regulation of receptor internalization; specification of axis polarity; vesicle-mediated transport; protein localization in organelle; cilium biogenesis; positive regulation of transcription from RNA polymerase II promoter; heart looping; transmembrane receptor protein tyrosine kinase signaling pathway; morphogenesis of a polarized epithelium; hindbrain development; regulation of behavior; negative regulation of apoptosis

Disease: Joubert Syndrome 3
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Product References and Citations for anti-AHI1 antibody

   (1) Otto,E.A., Ramaswami,G., Janssen,S., et al. Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy. J. Med. Genet. 48 (2), 105-116 (2011)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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