Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow AHR rightarrow Polyclonal AHR  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Tristetraprolin (TTP-ZFP36) ELISA Kit
 • interferon, gamma (IFNG) ELISA Kit
 • MMP-2 Antibody
 • Long neurotoxin 1 (Alpha-EPTX-Nk2a) Recombinant Protein
 • T cell receptor beta variable 12-3 (TRBV12-3) ELISA Kit
 • SOX14 cDNA Clone
 • Interleukin 21 (IL21) ELISA Kit
 • GAL9 ELISA Kit
 • 5HT2A Receptor (HTR2A) Peptide
 • Malaria Antibody
 • nerve growth factor receptor (TNFRSF16) associated protein 1... Antibody
 • CD2 - CD4 Antibody
 • Nerve Growth Factor (NGF) ELISA Kit
 • 5'-AMP-activated protein kinase subunit gamma-2 (PRKAG2) Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-AHR antibody :: Rabbit AHR Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240061
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AHR, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human AHR

 Product Synonym Names    Anti-AHR Antibody (C-Terminus) IHC-plus; AHR; Ah receptor; AH-receptor; Aryl hydrocarbon receptor; BHLHe76; Aromatic hydrocarbon receptor; Human AHR
 Product Gene Name   

anti-AHR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    600253
 3D Structure    ModBase 3D Structure for P35869
Section Bar
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Gorilla, Human
Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
Section Bar
 Specificity    Human Aryl Hydrocarbon Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except TCHHL1 (56%).
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
Section Bar
 Target Species    Human
 Immunogen Description    Synthetic 16 amino acid peptide from C-terminus of human Aryl Hydrocarbon Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon (94%); Monkey, Bat, Elephant, Guinea pig (88%).
 Immunogen Type    Synthetic peptide
 Immunogen    AHR antibody was raised against synthetic 16 amino acid peptide from C-terminus of human Aryl Hydrocarbon Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon (94%); Monkey, Bat, Elephant, Guinea pig (88%); Marmoset, Bovine, Hamster (81%).
 Antigen Modification    C-Terminus
Section Bar
 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-AHR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-AHR antibody

   Aryl hydrocarbon receptor is a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. AHR has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450.
 Applications Tested/Suitable for anti-AHR antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-AHR antibody    IHC-P (15 - 20 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
Section Bar
 Immunohistochemistry (IHC) of anti-AHR antibody    Anti-Aryl Hydrocarbon Receptor antibody IHC of human respiratory epithelium and bronchial smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-AHR antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for AHR. It may not necessarily be applicable to this product.
 NCBI GI #    4502003
 NCBI GeneID    196
 NCBI Accession #    NP_001612.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001621.4 [Other Products]
Section Bar
 UniProt Primary Accession #    P35869 [Other Products]
 UniProt Secondary Accession #    Q13728; Q13803; Q13804; A4D130 [Other Products]
 UniProt Related Accession #    P35869 [Other Products]
 Molecular Weight    96,147 Da
Table BarTOPTable Bar
 NCBI Official Full Name    aryl hydrocarbon receptor
 NCBI Official Synonym Full Names    aryl hydrocarbon receptor
 NCBI Official Symbol    AHR [Similar Products]
 NCBI Official Synonym Symbols   
bHLHe76
[Similar Products]
 NCBI Protein Information    aryl hydrocarbon receptor; AH-receptor; ah receptor; aromatic hydrocarbon receptor; class E basic helix-loop-helix protein 76
 UniProt Protein Name    Aryl hydrocarbon receptor
 UniProt Synonym Protein Names   
Class E basic helix-loop-helix protein 76; bHLHe76
 Protein Family    Aldehyde reductase
 UniProt Gene Name    AHR [Similar Products]
 UniProt Synonym Gene Names    BHLHE76; Ah receptor; AhR; bHLHe76 [Similar Products]
 UniProt Entry Name    AHR_HUMAN
Section Bar
 NCBI Summary for AHR    This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for AHR    AHR: a nuclear receptor for aryl hydrocarbons involved in xenobiotic metabolism, cell cycle regulation, and development in response to both endogenous and environmental signals. AhR was initially identified as a receptor for dioxins, which are environmental pollutants generated by waste incineration and other industrial processes . AhR ligands include polycyclic aromatic hydrocarbons, including the carcinogen benzo(a)pyrene and other components of cigarette smoke. Naturally occurring AhR ligands include flavonoids, which are aromatic plant secondary compounds commonly found in vegetables and fruits. Cytoplasmic aryl hydrocarbon receptors are found in protein complexes with heat shock proteins. Upon ligand binding, AhR dissociates from heat shock proteins and translocate to the nucleus where it dimerizes with AhR nuclear translocator (ARNT, HIF-1b). The AhR/ARNT heterodimer binds to nuclear xenobiotic response elements to control the expression of genes associated with xenobiotic metabolism, including several cytochrome P450 genes. AhR is ubiquitously expressed and is thought to play a role in regulation of cell proliferation and differentiation, cytokine expression, and xenobiotic metabolism. Research studies link AhR activity with the control of regulatory T-cell and T-helper 17 cell differentiation, regulation of the inflammatory response, and the onset of lung cancer.

Protein type: DNA-binding; Transcription factor; Nuclear receptor

Chromosomal Location of Human Ortholog: 7p15

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus

Molecular Function: protein dimerization activity; RNA polymerase II transcription factor activity, enhancer binding; signal transducer activity; ligand-dependent nuclear receptor activity; protein binding; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; Hsp90 protein binding; transcription factor activity; transcription factor binding

Biological Process: transcription from RNA polymerase II promoter; prostate gland development; blood vessel development; intracellular receptor-mediated signaling pathway; apoptosis; positive regulation of transcription, DNA-dependent; response to toxin; negative regulation of transcription from RNA polymerase II promoter; cell cycle; regulation of transcription from RNA polymerase II promoter; response to xenobiotic stimulus; regulation of transcription, DNA-dependent; regulation of gene expression; xenobiotic metabolic process; positive regulation of transcription from RNA polymerase II promoter; regulation of B cell proliferation; circadian regulation of gene expression; positive regulation of transcriptional preinitiation complex assembly; negative regulation of transcription, DNA-dependent
Table BarTOPTable Bar
 Research Articles on AHR    1. Through the modulation of E2F1, AHR regulates MYCN gene expression, which may in turn affect neuroblastoma differentiation.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-AHR antibodyPathways associated with anti-AHR antibody
 Reference Product  PubMed Publications
 CYP1A1 antibody  >1383 publications with AHR and CYP1A1
 ARNT antibody  >640 publications with AHR and ARNT
 CYP1B1 antibody  >382 publications with AHR and CYP1B1
 SRC antibody  >46 publications with AHR and SRC
 AIP antibody  >28 publications with AHR and AIP
 RELA antibody  >18 publications with AHR and RELA
 ESR1 antibody  >13 publications with AHR and ESR1
 RB1 antibody  >6 publications with AHR and RB1
 HSP90AA1 antibody  >3 publications with AHR and HSP90AA1
 SMARCA4 antibody  >2 publications with AHR and SMARCA4
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
Diseases associated with anti-AHR antibodyOrgans/Tissues associated with anti-AHR antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1334 publications with AHR and Inflammation
 Liver Diseases Antibodies  >345 publications with AHR and Liver Diseases
 Breast Neoplasms Antibodies  >260 publications with AHR and Breast Neoplasms
 Liver Neoplasms Antibodies  >254 publications with AHR and Liver Neoplasms
 Necrosis Antibodies  >211 publications with AHR and Necrosis
 Pneumonia Antibodies  >154 publications with AHR and Pneumonia
 Hyperplasia Antibodies  >149 publications with AHR and Hyperplasia
 Neoplasms, Experimental Antibodies  >143 publications with AHR and Neoplasms, Experimental
 Kidney Diseases Antibodies  >120 publications with AHR and Kidney Diseases
 Hypertension Antibodies  >110 publications with AHR and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1618 publications with AHR and Blood
 Lung Antibodies  >1425 publications with AHR and Lung
 Liver Antibodies  >1078 publications with AHR and Liver
 Muscle Antibodies  >396 publications with AHR and Muscle
 Kidney Antibodies  >377 publications with AHR and Kidney
 Heart Antibodies  >377 publications with AHR and Heart
 Vascular Antibodies  >283 publications with AHR and Vascular
 Skin Antibodies  >273 publications with AHR and Skin
 Brain Antibodies  >255 publications with AHR and Brain
 Bone Antibodies  >219 publications with AHR and Bone
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions