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anti-AHSG antibody :: Goat anti-Human AHSG / Fetuin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240601
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AHSG / Fetuin, Polyclonal Antibody

 Also Known As   

Goat Polyclonal to Human AHSG / Fetuin

 Product Synonym Names    Anti-AHSG / Fetuin Antibody IHC-plus; A2HS; Alpha-2-Z-globulin; Fetuin; Fetuin-A; AHS; Alpha-2-HS-glycoprotein; Ba-alpha-2-glycoprotein; FETUA; HSGA; Human AHSG; Fetuin
 Product Gene Name   

anti-AHSG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    138680
 3D Structure    ModBase 3D Structure for P02765
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Human
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 Specificity    Recombinant human fetuin (a2-HS glycoprotein) processed to remove a 40 amino acid residue bridging peptide resulting in the mature form of the protein.
 Purity/Purification    Purified IgG
 Form/Format    0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Resuspension Liquid Description    After adding water, will consist of 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01% (w/v) Sodium Azide
 Immunogen Description    Recombinant human AHSG / Fetuin.
 Immunogen Type    Recombinant protein
 Immunogen    AHSG / Fetuin antibody was raised against recombinant human AHSG / Fetuin.
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-AHSG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-AHSG antibody

   Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue.
 Applications Tested/Suitable for anti-AHSG antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP), ELISA (EIA)

 Application Notes for anti-AHSG antibody    ELISA, IHC-P (2.5 ug/ml), IP, WB (1:10000 - 1:20000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-AHSG antibody    Anti-AHSG / Fetuin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-AHSG antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-AHSG antibody    Anti-Fetuin Antibody - Western Blot. Western blot of Fetuin. Anti-Human Fetuin antibody, generated by immunization with mature protein, was tested by western blot against fetuin in purified preparations and in human plasma. Lane 1 contains 250 ng of purified human fetuin. Lane 2 contains 5 ul of a 1:50 dilution of human serum. Dilution of Anti-Human Fetuin antibody between 1:10000 and 1:20000 showed strong reactivity by western blot. In this blot the antibody was used at a 1:10000 dilution incubated 1 h at room temperature in 1% BSA in TTBS. Detection occurred using a 1:5000 dilution of IRDye800 conjugated Donkey anti-Goat IgG (code # for 45 min at room temperature. LICORs Odyssey Infrared Imaging System was used to scan and process the image. Other detection systems will yield similar results.
anti-AHSG antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-AHSG antibody    Immunoblot of Fetuin using anti-Human Fetuin (2-HS Glycoprotein) antibody at a 1:10,000 to 1:20,000 dilution. Lane 1 contains 250 ng of purified human fetuin. Lane 2 contains 5 ml of a 1:50 dilution of human serum. Data contributed by Dr. George Grunberger, Wayne State University.
anti-AHSG antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for AHSG. It may not necessarily be applicable to this product.
 NCBI GI #    156523970
 NCBI GeneID    197
 NCBI Accession #    NP_001613.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001622.2 [Other Products]
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 UniProt Primary Accession #    P02765 [Other Products]
 UniProt Secondary Accession #    O14961; O14962; Q9P152; A8K9N6; B2R7G1 [Other Products]
 UniProt Related Accession #    P02765; AAB29984 [Other Products]
 Molecular Weight    39,325 Da
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 NCBI Official Full Name    alpha-2-HS-glycoprotein preproprotein
 NCBI Official Synonym Full Names    alpha-2-HS-glycoprotein
 NCBI Official Symbol    AHSG [Similar Products]
 NCBI Official Synonym Symbols   
AHS; A2HS; HSGA; FETUA
[Similar Products]
 NCBI Protein Information    alpha-2-HS-glycoprotein; fetuin-A; alpha-2-Z-globulin; ba-alpha-2-glycoprotein
 UniProt Protein Name    Alpha-2-HS-glycoprotein
 UniProt Synonym Protein Names   
Alpha-2-Z-globulin; Ba-alpha-2-glycoprotein; Fetuin-ACleaved into the following 2 chains:Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B
 Protein Family    Alpha-2-HS-glycoprotein
 UniProt Gene Name    AHSG [Similar Products]
 UniProt Synonym Gene Names    FETUA [Similar Products]
 UniProt Entry Name    FETUA_HUMAN
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 NCBI Summary for AHSG    Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AHSG    FETUA: Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions. Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond. Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins. Belongs to the fetuin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3q27

Cellular Component: extracellular space; extracellular region

Molecular Function: kinase inhibitor activity; cysteine protease inhibitor activity

Biological Process: pinocytosis; negative regulation of bone mineralization; ossification; positive regulation of phagocytosis; regulation of inflammatory response; acute-phase response; negative regulation of insulin receptor signaling pathway; negative regulation of phosphorylation; regulation of bone mineralization; skeletal development
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 Research Articles on AHSG    1. Fetuin-A and/or palmitate influence the expression of proinflammatory and angiogenic proteins only partially via TLR4 signalling
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AHSG antibodyPathways associated with anti-AHSG antibody
 Reference Product  PubMed Publications
 HRG antibody  >4 publications with AHSG and HRG
 ALB antibody  >3 publications with AHSG and ALB
 BMP2 antibody  >2 publications with AHSG and BMP2
 AMBP antibody  >2 publications with AHSG and AMBP
 SERPINC1 antibody  >1 publications with AHSG and SERPINC1
 APOA2 antibody  >1 publications with AHSG and APOA2
 APOH antibody  >1 publications with AHSG and APOH
 Products by Pathway  Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
Diseases associated with anti-AHSG antibodyOrgans/Tissues associated with anti-AHSG antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >112 publications with AHSG and Kidney Diseases
 Calcinosis Antibodies  >98 publications with AHSG and Calcinosis
 Inflammation Antibodies  >84 publications with AHSG and Inflammation
 Heart Diseases Antibodies  >55 publications with AHSG and Heart Diseases
 Liver Diseases Antibodies  >45 publications with AHSG and Liver Diseases
 Brain Diseases Antibodies  >21 publications with AHSG and Brain Diseases
 Liver Neoplasms Antibodies  >18 publications with AHSG and Liver Neoplasms
 Fatty Liver Antibodies  >16 publications with AHSG and Fatty Liver
 Myocardial Infarction Antibodies  >15 publications with AHSG and Myocardial Infarction
 Heart Failure Antibodies  >14 publications with AHSG and Heart Failure
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >497 publications with AHSG and Blood
 Liver Antibodies  >92 publications with AHSG and Liver
 Heart Antibodies  >38 publications with AHSG and Heart
 Muscle Antibodies  >34 publications with AHSG and Muscle
 Brain Antibodies  >19 publications with AHSG and Brain
 Lung Antibodies  >10 publications with AHSG and Lung
 Spleen Antibodies  >4 publications with AHSG and Spleen
 Embryonic Tissue Antibodies  >4 publications with AHSG and Embryonic Tissue
 Thymus Antibodies  >2 publications with AHSG and Thymus
 Testis Antibodies  >2 publications with AHSG and Testis
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