Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
Fax 1.858.633.0166    Email 
menu1 Home Products Ordering Company Help menu7
   MyBioSource rightarrow Antibody rightarrow AICDA rightarrow Polyclonal AICDA  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
Our Best Sellers moreseparator
 • Aldolase A (ALDOA) Antibody
 • Akt 1 Antibody
 • Putative defensin-like protein 73 (LCR44) Recombinant Protein
 • Glutamine synthetase (GS) ELISA Kit
 • NT-proBNP Antibody
 • TNFalpha ELISA Kit
 • FAT3 Antibody
 • Peptide Yy (PYY) ELISA Kit
 • matrix metallopeptidase 13 (collagenase 3) (MMP13) ELISA Kit
 • C1QB Antibody
 • Superoxide Dismutase 1, Soluble (SOD1) ELISA Kit
 • OCT-2 (POU2F2) Antibody
 downarrow more ...
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-AICDA antibody :: Rabbit anti-Human AICDA / AID Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242990
Immunohistochemistry (IHC)
Unit / Price
0.1 mL  /  $530 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AICDA / AID, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human AICDA / AID

 Product Synonym Names    Anti-AICDA / AID Antibody (N-Terminus) IHC-plus; AICDA; AID; ARP2; CDA2; Cytidine aminohydrolase; HIGM2; Human AICDA; AID
 Product Gene Name   

anti-AICDA antibody

[Similar Products]
 Product Synonym Gene Name    AID [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    gene 605258
 3D Structure    ModBase 3D Structure for Q9GZX7
Section Bar
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
Section Bar
 Specificity    Human 24 kD AICDA protein
 Purity/Purification    Unpurified serum
 Form/Format    Lyophilized antiserum
Section Bar
 Target Species    Human
 Resuspension Liquid Description    Distilled water
 Immunogen Description    Synthetic peptide
 Immunogen Type    Synthetic peptide
 Antigen Modification    N-Terminus
Section Bar
 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-AICDA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar

Related Product Information for anti-AICDA antibody

   Activation-induced cytidine deaminase (AICDA) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines. AICDA is necessary for somatic hypermutation and class switch recombination in B cells, but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms.
 Applications Tested/Suitable for anti-AICDA antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-AICDA antibody    IHC-P (1:100 - 1:200), WB (1:500 - 1:2000)
Section Bar
 Immunohistochemistry (IHC) of anti-AICDA antibody    Anti-AICDA antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-AICDA antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for AICDA. It may not necessarily be applicable to this product.
 NCBI GI #    10190700
 NCBI GeneID    57379
 NCBI Accession #    NP_065712.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020661.2 [Other Products]
Section Bar
 UniProt Primary Accession #    Q9GZX7 [Other Products]
 UniProt Secondary Accession #    Q6QJ81; Q8NFC1 [Other Products]
 UniProt Related Accession #    Q9GZX7 [Other Products]
 Molecular Weight    22,614 Da
Table BarTOPTable Bar
 NCBI Official Full Name    single-stranded DNA cytosine deaminase
 NCBI Official Synonym Full Names    activation-induced cytidine deaminase
 NCBI Official Symbol    AICDA [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    single-stranded DNA cytosine deaminase; cytidine aminohydrolase; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos
 UniProt Protein Name    Single-stranded DNA cytosine deaminase
 UniProt Synonym Protein Names   
Activation-induced cytidine deaminase; Cytidine aminohydrolase
 Protein Family    Single-stranded DNA cytosine deaminase
 UniProt Gene Name    AICDA [Similar Products]
 UniProt Synonym Gene Names    AID [Similar Products]
 UniProt Entry Name    AICDA_HUMAN
Section Bar
 NCBI Summary for AICDA    This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]
Section Bar
 UniProt Comments for AICDA    AID: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family.

Protein type: EC; Hydrolase

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cytoplasm; exosome (RNase complex); nucleus

Molecular Function: protein binding; zinc ion binding; ubiquitin protein ligase binding; cytidine deaminase activity

Biological Process: somatic diversification of immunoglobulins; B cell differentiation; somatic hypermutation of immunoglobulin genes; isotype switching; cytidine deamination; mRNA processing

Disease: Immunodeficiency With Hyper-igm, Type 2
Table BarTOPTable Bar
 Research Articles on AICDA    1. analysis of a possible association between AID expression and BRAF mutation in melanoma
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-AICDA antibodyPathways associated with anti-AICDA antibody
 Reference Product  PubMed Publications
 TNFSF13B antibody  >6 publications with AICDA and TNFSF13B
 STAT6 antibody  >5 publications with AICDA and STAT6
 IL4 antibody  >3 publications with AICDA and IL4
 Products by Pathway  Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
Diseases associated with anti-AICDA antibodyOrgans/Tissues associated with anti-AICDA antibody
 Disease Name  Pubmed Publications
 Leukemia Antibodies  >64 publications with AICDA and Leukemia
 Leukemia, Lymphoid Antibodies  >45 publications with AICDA and Leukemia, Lymphoid
 Autoimmune Diseases Antibodies  >38 publications with AICDA and Autoimmune Diseases
 Inflammation Antibodies  >37 publications with AICDA and Inflammation
 Necrosis Antibodies  >28 publications with AICDA and Necrosis
 Disease Models, Animal Antibodies  >25 publications with AICDA and Disease Models, Animal
 Hyper-IgM Immunodeficiency Syndrome Antibodies  >19 publications with AICDA and Hyper-IgM Immunodeficiency Syndrome
 Liver Diseases Antibodies  >17 publications with AICDA and Liver Diseases
 Adenocarcinoma Antibodies  >13 publications with AICDA and Adenocarcinoma
 Nervous System Diseases Antibodies  >12 publications with AICDA and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >452 publications with AICDA and Blood
 Lymph Node Antibodies  >99 publications with AICDA and Lymph Node
 Lymph Antibodies  >26 publications with AICDA and Lymph
 Kidney Antibodies  >26 publications with AICDA and Kidney
 Tonsil Antibodies  >12 publications with AICDA and Tonsil
 Pharynx Antibodies  >8 publications with AICDA and Pharynx
 Testis Antibodies  >2 publications with AICDA and Testis
 Pancreas Antibodies  >1 publications with AICDA and Pancreas
 Uncharacterized Tissue Antibodies  >1 publications with AICDA and Uncharacterized Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions