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anti-AIF1 antibody :: Rabbit AIF1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS126264
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AIF1, Polyclonal Antibody

 Also Known As   

AIF1 Polyclonal Antibody

 Product Synonym Names    IBA1; IRT1; AIF-1; IRT-1
 Product Gene Name   

anti-AIF1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601833
 3D Structure    ModBase 3D Structure for P55008
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human AIF1
 Calculated Molecular Weight    17kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-AIF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-AIF1 antibody

   This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
 Product Categories/Family for anti-AIF1 antibody    Polyclonal
 Applications Tested/Suitable for anti-AIF1 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-AIF1 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
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 Western Blot (WB) of anti-AIF1 antibody    Western blot analysis of extracts of various cell lines, using AIF1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 10s.
anti-AIF1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-AIF1 antibody    Immunohistochemistry of paraffin-embedded mouse lung using AIF1 antibody at dilution of 1:100 (40x lens).
anti-AIF1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-AIF1 antibody    Immunohistochemistry of paraffin-embedded human lung injury using AIF1 antibody at dilution of 1:100 (40x lens).
anti-AIF1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-AIF1 antibody    Immunohistochemistry of paraffin-embedded human gastric cancer using AIF1 antibody at dilution of 1:100 (40x lens).
anti-AIF1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for AIF1. It may not necessarily be applicable to this product.
 NCBI GI #    1703217
 NCBI GeneID    199
 NCBI Accession #    P55008.1 [Other Products]
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 UniProt Primary Accession #    P55008 [Other Products]
 UniProt Secondary Accession #    O43904; Q9UIV4; Q9UKS9; A8K406 [Other Products]
 UniProt Related Accession #    P55008 [Other Products]
 Molecular Weight    147
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 NCBI Official Full Name    Allograft inflammatory factor 1
 NCBI Official Synonym Full Names    allograft inflammatory factor 1
 NCBI Official Symbol    AIF1 [Similar Products]
 NCBI Official Synonym Symbols   
IBA1; IRT1; AIF-1; IRT-1
[Similar Products]
 NCBI Protein Information    allograft inflammatory factor 1; protein G1; interferon gamma responsive transcript; ionized calcium-binding adapter molecule 1; allograft inflammatory factor-1 splice variant Hara-1
 UniProt Protein Name    Allograft inflammatory factor 1
 UniProt Synonym Protein Names   
Ionized calcium-binding adapter molecule 1; Protein G1
 Protein Family    Apoptosis-inducing factor
 UniProt Gene Name    AIF1 [Similar Products]
 UniProt Synonym Gene Names    G1; IBA1; AIF-1 [Similar Products]
 UniProt Entry Name    AIF1_HUMAN
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 NCBI Summary for AIF1    This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
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 UniProt Comments for AIF1    AIF1: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: perinuclear region of cytoplasm; lamellipodium; cytoplasm; actin filament; perikaryon; nucleus; cytosol; phagocytic cup

Molecular Function: actin filament binding; calcium ion binding

Biological Process: actin filament bundle formation; positive regulation of nitric oxide biosynthetic process; negative regulation of smooth muscle cell proliferation; positive regulation of smooth muscle cell proliferation; microglial cell activation; Rac protein signal transduction; cellular response to hormone stimulus; actin filament polymerization; positive regulation of muscle hyperplasia; cellular response to extracellular stimulus; positive regulation of T cell proliferation; response to axon injury; positive regulation of protein amino acid phosphorylation; phagocytosis, engulfment; response to electrical stimulus; inflammatory response; negative regulation of apoptosis
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 Research Articles on AIF1    1. AIF-1 functions as a tumor suppressor possibly by regulating beta-catenin in gastric cancer. the level of AIF-1 expression may serve as a protective prognostic indicator for gastric cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AIF1 antibodyPathways associated with anti-AIF1 antibody
 Reference Product  PubMed Publications
 GFAP antibody  >97 publications with AIF1 and GFAP
 RAC1 antibody  >4 publications with AIF1 and RAC1
 TYROBP antibody  >2 publications with AIF1 and TYROBP
 Products by Pathway  Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
Diseases associated with anti-AIF1 antibodyOrgans/Tissues associated with anti-AIF1 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >277 publications with AIF1 and Disease Models, Animal
 Inflammation Antibodies  >155 publications with AIF1 and Inflammation
 Death Antibodies  >115 publications with AIF1 and Death
 Cardiovascular Diseases Antibodies  >99 publications with AIF1 and Cardiovascular Diseases
 Necrosis Antibodies  >90 publications with AIF1 and Necrosis
 Nerve Degeneration Antibodies  >43 publications with AIF1 and Nerve Degeneration
 Cognition Disorders Antibodies  >16 publications with AIF1 and Cognition Disorders
 Neurotoxicity Syndromes Antibodies  >16 publications with AIF1 and Neurotoxicity Syndromes
 Edema Antibodies  >13 publications with AIF1 and Edema
 Parkinson Disease Antibodies  >12 publications with AIF1 and Parkinson Disease
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >414 publications with AIF1 and Brain
 Blood Antibodies  >144 publications with AIF1 and Blood
 Vascular Antibodies  >62 publications with AIF1 and Vascular
 Muscle Antibodies  >48 publications with AIF1 and Muscle
 Bone Marrow Antibodies  >40 publications with AIF1 and Bone Marrow
 Eye Antibodies  >29 publications with AIF1 and Eye
 Embryonic Tissue Antibodies  >19 publications with AIF1 and Embryonic Tissue
 Heart Antibodies  >18 publications with AIF1 and Heart
 Spleen Antibodies  >14 publications with AIF1 and Spleen
 Skin Antibodies  >14 publications with AIF1 and Skin
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