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anti-AIP antibody :: Goat AIP/ARA9 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421237
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AIP/ARA9, Polyclonal Antibody

 Also Known As   

Goat anti-AIP/ARA9 Antibody

 Product Synonym Names    AIP; ARA9; aryl hydrocarbon receptor interacting protein; FKBP16; FKBP37; XAP2; HBV-X associated protein; aryl hydrocarbon receptor-interacting protein; AIP antibody; ARA9 antibody; aryl hydrocarbon receptor interacting protein antibody; FKBP16 antibody; FKBP37 antibody; XAP2 antibody; HBV-X associated protein antibody; aryl hydrocarbon receptor-interacting protein antibody; AIP / ARA9
 Product Gene Name   

anti-AIP antibody

[Similar Products]
 Product Synonym Gene Name    ARA9 [Similar Products]
 Antibody/Peptide Pairs    AIP / ARA9 peptide (MBS427008) is used for blocking the activity of AIP/ARA9 antibody (MBS421237)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    EARIRQKDEE DKAR
 OMIM    102200
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Mouse, Human; Expected from sequence similarity: Human, Mouse, Rat, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-EARIRQKDEEDKAR, from the C Terminus of the protein sequence according to NP_003968.1.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-AIP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-AIP antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-AIP antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 37kDa band observed in lysates of cell line NIH/3T3 (calculated MW of 37.7kDa according to Human NP_003968.1 and 37.6kDa according to mouse NP_057875.1). In transfected HEK293 transiently expressing ARA9 a band of approx. 42kDa is observed. This band is not observed in the non-transfected HEK293. Recommended concentration: 0. 02-0. 06ug/ml.
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 Western Blot (WB) of anti-AIP antibody    (0. 02ug/ml) staining of NIH/3T3 cell lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-AIP antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-AIP antibody    HEK293 overexpressing ARA9 (RC211157) and probed (mock transfection in first lane), tested by Origene.
anti-AIP antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for AIP. It may not necessarily be applicable to this product.
 NCBI GI #    4502009
 NCBI GeneID    9049
 NCBI Accession #    NP_003968.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003977.1 [Other Products]
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 UniProt Secondary Accession #    Q2M3Q2; Q99606; A0SZW3; A0SZW4; A0SZW5; A0SZW6 [Other Products]
 UniProt Related Accession #    O00170 [Other Products]
 Molecular Weight    37,636 Da
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 NCBI Official Full Name    aryl hydrocarbon receptor interacting protein
 NCBI Official Synonym Full Names    aryl hydrocarbon receptor interacting protein
 NCBI Official Symbol    AIP [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    AH receptor-interacting protein
 UniProt Protein Name    AH receptor-interacting protein
 UniProt Synonym Protein Names   
Aryl-hydrocarbon receptor-interacting protein; HBV X-associated protein 2; XAP-2; Immunophilin homolog ARA9
 Protein Family    AH receptor-interacting protein
 UniProt Gene Name    AIP [Similar Products]
 UniProt Synonym Gene Names    XAP2; AIP; XAP-2 [Similar Products]
 UniProt Entry Name    AIP_HUMAN
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 NCBI Summary for AIP    The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
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 UniProt Comments for AIP    AIP: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Defects in AIP are a cause of growth hormone-secreting pituitary adenoma (GHSPA); also known as familial isolated somatotropinomas (FIS) or isolated familial somatotropinoma (IFS) or familial somatotrophinoma or acromegaly due to pituitary adenoma. Defects in AIP are a cause of ACTH-secreting pituitary adenoma (ASPA); also known as pituitary Cushing disease. A pituary adenoma resulting in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and trunkal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. Defects in AIP are a cause of prolactin-secreting pituitary adenoma (PSPA); also known as prolactinoma. Prolactin-secreting pituitary adenoma is the most common type of hormonally active pituitary adenoma.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: cytoplasm; cytosol; nucleoplasm; plasma membrane

Molecular Function: aryl hydrocarbon receptor binding; protein binding; signal transducer activity; transcription coactivator activity; transcription factor binding; unfolded protein binding

Biological Process: negative regulation of cyclic-nucleotide phosphodiesterase activity; protein maturation via protein folding; protein targeting to mitochondrion; signal transduction; xenobiotic metabolic process

Disease: Pituitary Adenoma, Acth-secreting; Pituitary Adenoma, Growth Hormone-secreting; Pituitary Adenoma, Prolactin-secreting
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 Research Articles on AIP    1. in a family of a patient with gigantism, identified a new AIP germline mutation (c.685C>T, p.Q229X) predicted to produce a truncated AIP protein, lacking its biological properties due to the disruption of the C-terminus binding sites for both the chaperones and the client proteins of AIP
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AIP antibodyPathways associated with anti-AIP antibody
 Reference Product  PubMed Publications
 AHR antibody  >33 publications with AIP and AHR
 ARNT antibody  >13 publications with AIP and ARNT
 RET antibody  >9 publications with AIP and RET
 UBC antibody  >4 publications with AIP and UBC
 TOMM20 antibody  >2 publications with AIP and TOMM20
 PDE4A antibody  >1 publications with AIP and PDE4A
 PDE2A antibody  >1 publications with AIP and PDE2A
 HSP90AA1 antibody  >1 publications with AIP and HSP90AA1
 Products by Pathway  Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
Diseases associated with anti-AIP antibodyOrgans/Tissues associated with anti-AIP antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >365 publications with AIP and Liver Diseases
 Fibrosis Antibodies  >231 publications with AIP and Fibrosis
 Adenoma Antibodies  >132 publications with AIP and Adenoma
 Inflammation Antibodies  >115 publications with AIP and Inflammation
 Kidney Diseases Antibodies  >64 publications with AIP and Kidney Diseases
 Growth Hormone-Secreting Pituitary Adenoma Antibodies  >48 publications with AIP and Growth Hormone-Secreting Pituitary Adenoma
 Heart Diseases Antibodies  >47 publications with AIP and Heart Diseases
 Necrosis Antibodies  >38 publications with AIP and Necrosis
 Intestinal Diseases Antibodies  >38 publications with AIP and Intestinal Diseases
 Poisoning Antibodies  >37 publications with AIP and Poisoning
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >616 publications with AIP and Blood
 Pancreas Antibodies  >414 publications with AIP and Pancreas
 Liver Antibodies  >230 publications with AIP and Liver
 Brain Antibodies  >223 publications with AIP and Brain
 Lung Antibodies  >137 publications with AIP and Lung
 Muscle Antibodies  >90 publications with AIP and Muscle
 Kidney Antibodies  >86 publications with AIP and Kidney
 Heart Antibodies  >85 publications with AIP and Heart
 Salivary Gland Antibodies  >63 publications with AIP and Salivary Gland
 Vascular Antibodies  >62 publications with AIP and Vascular
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