NP_001616.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,636 Da
NCBI Official Full Name
adenylate kinase 2, mitochondrial isoform a
NCBI Official Synonym Full Names
adenylate kinase 2
NCBI Official Synonym Symbols
NCBI Protein Information
adenylate kinase 2, mitochondrial
UniProt Protein Name
Adenylate kinase 2, mitochondrial
UniProt Synonym Protein Names
ATP-AMP transphosphorylase 2
UniProt Synonym Gene Names
NCBI Summary for AK2
Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010]
UniProt Comments for AK2
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
Product References and Citations for anti-AK2 antibody
(1) Lee, H.J., Pyo, J.O., Oh, Y., et al.AK2 activates a novel apoptotic pathway through formation of a complex with FADD and caspase-10.Nat. Cell Biol. 9 (11), 1303-1310 (2007).
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Pathways associated with anti-AK2 antibody
Diseases associated with anti-AK2 antibody
Organs/Tissues associated with anti-AK2 antibody
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