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anti-AKAP10 antibody :: Goat AKAP10 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421105
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AKAP10, Polyclonal Antibody

 Also Known As   

Goat anti-AKAP10 Antibody

 Product Synonym Names    Goat Anti-AKAP10 / D-AKAP2 Antibody; AKAP10; A kinase (PRKA) anchor protein 10; D-AKAP2; MGC9414; PRKA10; A-kinase anchor protein 10; dual-specificity A-kinase anchoring protein 2; mitochondrial A kinase PPKA anchor protein 10; protein kinase A anchoring protein 10; AKAP10 antibody; A kinase (PRKA) anchor protein 10 antibody; D-AKAP2 antibody; MGC9414 antibody; PRKA10 antibody; A-kinase anchor protein 10 antibody; dual-specificity A-kinase anchoring protein 2 antibody; mitochondrial A kinase PPKA anchor protein 10 antibody; protein kinase A anchoring protein 10 antibody
 Product Gene Name   

anti-AKAP10 antibody

[Similar Products]
 Antibody/Peptide Pairs    AKAP10 peptide (MBS426677) is used for blocking the activity of AKAP10 antibody (MBS421105)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    RKVKGKEQEK TSD
 OMIM    115080
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-RKVKGKEQEKTSD, from the internal region of the protein sequence according to NP_009133.2.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-AKAP10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-AKAP10 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-AKAP10 antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx.74kDa band observed in Rat Brain lysates (calculated MW of 73.8kDa according to Human NP_009133.2 and according to Rat NP_001108078.1). Recommended concentration: 0.3-1ug/ml.
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 Western Blot (WB) of anti-AKAP10 antibody    (1ug/ml) staining of Rat Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-AKAP10 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for AKAP10. It may not necessarily be applicable to this product.
 NCBI GI #    21493033
 NCBI GeneID    11216
 NCBI Accession #    NP_009133.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_007202.3 [Other Products]
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 UniProt Secondary Accession #    Q96AJ7; B2R650 [Other Products]
 UniProt Related Accession #    O43572 [Other Products]
 Molecular Weight    73,818 Da
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 NCBI Official Full Name    A-kinase anchor protein 10, mitochondrial
 NCBI Official Synonym Full Names    A-kinase anchoring protein 10
 NCBI Official Symbol    AKAP10 [Similar Products]
 NCBI Official Synonym Symbols   
PRKA10; AKAP-10; D-AKAP2; D-AKAP-2
[Similar Products]
 NCBI Protein Information    A-kinase anchor protein 10, mitochondrial
 UniProt Protein Name    A-kinase anchor protein 10, mitochondrial
 UniProt Synonym Protein Names   
Dual specificity A kinase-anchoring protein 2; D-AKAP-2; Protein kinase A-anchoring protein 10; PRKA10
 Protein Family    A-kinase anchor protein
 UniProt Gene Name    AKAP10 [Similar Products]
 UniProt Synonym Gene Names    AKAP-10; D-AKAP-2; PRKA10 [Similar Products]
 UniProt Entry Name    AKA10_HUMAN
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 NCBI Summary for AKAP10    This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]
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 UniProt Comments for AKAP10    AKAP10: Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase. Genetic variations in AKAP10 are a cause of susceptibility to sudden cardiac death (SCD). Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death. Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17p11.1

Cellular Component: cytoplasm; cytosol; mitochondrion; plasma membrane

Biological Process: blood coagulation; protein localization; signal transduction

Disease: Cardiac Conduction Defect
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 Research Articles on AKAP10    1. Its signaling pathway is associated with the progression and prognosis of colorectal neoplasms.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Goat anti-AKAP10 Antibody
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 MBS7211272  Monkey A-kinase anchor protein 10, mitochondrial (AKAP10) ELISA Kit  MBS7223440  Rat A-kinase anchor protein 10, mitochondrial (AKAP10) ELISA Kit
 MBS9410401  AKAP10 antibody  MBS8204960  AKAP10 siRNA (Human)
 MBS851966  AKAP10 Antibody  MBS428101  AKAP10 / D-AKAP2 Immunizing Peptide
Products associated with anti-AKAP10 antibodyPathways associated with anti-AKAP10 antibody
 Reference Product  PubMed Publications
 PDZK1 antibody  >2 publications with AKAP10 and PDZK1
 AKAP1 antibody  >2 publications with AKAP10 and AKAP1
 PRKAR1A antibody  >2 publications with AKAP10 and PRKAR1A
 PRKAR2A antibody  >1 publications with AKAP10 and PRKAR2A
 Products by Pathway  Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 G Protein Signaling Pathways antibodies  G Protein Signaling Pathways Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-AKAP10 antibodyOrgans/Tissues associated with anti-AKAP10 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >2 publications with AKAP10 and Breast Neoplasms
 Necrosis Antibodies  >2 publications with AKAP10 and Necrosis
 Heart Defects, Congenital Antibodies  >1 publications with AKAP10 and Heart Defects, Congenital
 Neoplasm Metastasis Antibodies  >1 publications with AKAP10 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >7 publications with AKAP10 and Heart
 Blood Antibodies  >5 publications with AKAP10 and Blood
 Muscle Antibodies  >4 publications with AKAP10 and Muscle
 Kidney Antibodies  >4 publications with AKAP10 and Kidney
 Brain Antibodies  >3 publications with AKAP10 and Brain
 Embryonic Tissue Antibodies  >2 publications with AKAP10 and Embryonic Tissue
 Lymph Node Antibodies  >1 publications with AKAP10 and Lymph Node
 Intestine Antibodies  >1 publications with AKAP10 and Intestine
 Testis Antibodies  >1 publications with AKAP10 and Testis
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