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anti-AKAP13 antibody :: Rabbit anti-Human AKAP13 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS821708
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AKAP13, Polyclonal Antibody

 Also Known As   

Anti-AKAP13 Antibody

 Product Synonym Names    BRX; HT31; LBC; A-kinase anchor protein 13; AKAP-13; AKAP-Lbc; Breast cancer nuclear receptor-binding auxiliary protein; Guanine nucleotide exchange factor Lbc; Human thyroid-anchoring protein 31; Lymphoid blast crisis oncogene; LBC oncogene; Non-oncogenic Rho GTPase-specific GTP exchange factor; Protein kinase A-anchoring protein 13; PRKA13; p47
 Product Gene Name   

anti-AKAP13 antibody

[Similar Products]
 Antibody/Peptide Pairs    AKAP13 peptide (MBS823639) is used for blocking the activity of AKAP13 antibody (MBS821708)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604686
 3D Structure    ModBase 3D Structure for Q12802
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes endogenous levels of AKAP13 protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the center region of human AKAP13. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-AKAP13 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-AKAP13 antibody

   Rabbit polyclonal antibody to AKAP13
 Applications Tested/Suitable for anti-AKAP13 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

 Application Notes for anti-AKAP13 antibody    WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/ICC (1/100 - 1/500)
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 Western Blot (WB) of anti-AKAP13 antibody    anti-AKAP13 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-AKAP13 antibody    Immunohistochemical analysis of AKAP13 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-AKAP13 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence/Immunocytochemistry (IF/ICC) of anti-AKAP13 antibody    Immunofluorescent analysis of AKAP13 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 degree C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
anti-AKAP13 antibody Immunofluorescence/Immunocytochemistry (IF/ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for AKAP13. It may not necessarily be applicable to this product.
 NCBI GI #    395627649
 NCBI GeneID    11214
 NCBI Accession #    NP_001257475.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001270546.1 [Other Products]
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 UniProt Primary Accession #    Q12802 [Other Products]
 UniProt Secondary Accession #    Q14572; Q59FP6; Q86W90; Q8WXQ6; Q96JP6; Q96P79; Q9Y5T0; Q9Y5T6 [Other Products]
 UniProt Related Accession #    Q12802 [Other Products]
 Molecular Weight    19,992 Da
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 NCBI Official Full Name    A-kinase anchor protein 13 isoform 4
 NCBI Official Synonym Full Names    A kinase (PRKA) anchor protein 13
 NCBI Official Symbol    AKAP13 [Similar Products]
 NCBI Official Synonym Symbols   
BRX; LBC; p47; HA-3; Ht31; c-lbc; PRKA13; AKAP-13; AKAP-Lbc; ARHGEF13; PROTO-LB; PROTO-LBC
[Similar Products]
 NCBI Protein Information    A-kinase anchor protein 13; LBC oncogene; A-kinase anchoring protein; lymphoid blast crisis oncogene; human thyroid-anchoring protein 31; protein kinase A-anchoring protein 13; guanine nucleotide exchange factor Lbc; non-oncogenic Rho GTPase-specific GTP exchange factor; breast cancer nuclear receptor-binding auxiliary protein
 UniProt Protein Name    A-kinase anchor protein 13
 UniProt Synonym Protein Names   
AKAP-Lbc; Breast cancer nuclear receptor-binding auxiliary protein; Guanine nucleotide exchange factor Lbc; Human thyroid-anchoring protein 31; Lymphoid blast crisis oncogene; LBC oncogene; Non-oncogenic Rho GTPase-specific GTP exchange factor; Protein kinase A-anchoring protein 13; PRKA13; p47
 Protein Family    A-kinase anchor protein
 UniProt Gene Name    AKAP13 [Similar Products]
 UniProt Synonym Gene Names    BRX; HT31; LBC; AKAP-13; LBC oncogene; PRKA13 [Similar Products]
 UniProt Entry Name    AKP13_HUMAN
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 NCBI Summary for AKAP13    The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]
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 UniProt Comments for AKAP13    AKAP13: Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element- specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; Nuclear export; Adaptor/scaffold; GEFs, Rac/Rho; GEFs; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 15q24-q25

Cellular Component: membrane; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus

Molecular Function: signal transducer activity; Rho guanyl-nucleotide exchange factor activity; protein binding; Rho GTPase binding; cAMP-dependent protein kinase activity; metal ion binding; protein kinase A binding; protein complex scaffold

Biological Process: regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; nuclear export; regulation of protein kinase activity; protein amino acid phosphorylation
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 Research Articles on AKAP13    1. activation of IKKbeta within the AKAP-Lbc complex promotes NF-kappaB-dependent production of interleukin-6
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-AKAP13 antibodyDiseases associated with anti-AKAP13 antibody
 Products by Pathway  Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 G Protein Signaling Pathways antibodies  G Protein Signaling Pathways Diagram
 G Alpha (12/13) Signalling Events Pathway antibodies  G Alpha (12/13) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 NRAGE Signals Death Through JNK Pathway antibodies  NRAGE Signals Death Through JNK Pathway Diagram
 Regulation Of RhoA Activity Pathway antibodies  Regulation Of RhoA Activity Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram
 Disease Name  Pubmed Publications
 Hypertrophy Antibodies  >11 publications with AKAP13 and Hypertrophy
 Cell Transformation, Neoplastic Antibodies  >7 publications with AKAP13 and Cell Transformation, Neoplastic
 Heart Diseases Antibodies  >6 publications with AKAP13 and Heart Diseases
 Breast Neoplasms Antibodies  >5 publications with AKAP13 and Breast Neoplasms
 Heart Failure Antibodies  >4 publications with AKAP13 and Heart Failure
 Inflammation Antibodies  >3 publications with AKAP13 and Inflammation
 Atherosclerosis Antibodies  >1 publications with AKAP13 and Atherosclerosis
 Disease Models, Animal Antibodies  >1 publications with AKAP13 and Disease Models, Animal
 Liver Neoplasms Antibodies  >1 publications with AKAP13 and Liver Neoplasms
 Nervous System Diseases Antibodies  >1 publications with AKAP13 and Nervous System Diseases
Organs/Tissues associated with anti-AKAP13 antibody
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >14 publications with AKAP13 and Heart
 Muscle Antibodies  >13 publications with AKAP13 and Muscle
 Blood Antibodies  >11 publications with AKAP13 and Blood
 Lung Antibodies  >5 publications with AKAP13 and Lung
 Vascular Antibodies  >4 publications with AKAP13 and Vascular
 Bone Antibodies  >4 publications with AKAP13 and Bone
 Uterus Antibodies  >3 publications with AKAP13 and Uterus
 Kidney Antibodies  >3 publications with AKAP13 and Kidney
 Eye Antibodies  >2 publications with AKAP13 and Eye
 Lymph Antibodies  >2 publications with AKAP13 and Lymph
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