BC131516
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,088 Da
NCBI Official Full Name
Homo sapiens A kinase (PRKA) anchor protein 5, mRNA
NCBI Official Synonym Full Names
A kinase (PRKA) anchor protein 5
NCBI Protein Information
A-kinase anchor protein 5; A-kinase anchor protein 79 kDa; A-kinase anchoring protein 75/79; AKAP 79; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein
UniProt Protein Name
A-kinase anchor protein 5
UniProt Synonym Protein Names
A-kinase anchor protein 79 kDa; AKAP 79; H21; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein
UniProt Entry Name
AKAP5_HUMAN
NCBI Summary for AKAP5
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]
UniProt Comments for AKAP5
AKAP5: May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Binding protein for dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (PKA) and also for the protein kinase C (PKC) and the phosphatase calcineurin (PP2B). Each enzyme is inhibited when bound to the anchoring protein. Also binds the beta2-adrenergic receptor. Part of a complex containing AKAP5, ADCY5, ADCY6 AND PDE4C. Interacts with ADCY8, and enhances its phosphorylation at lipid rafts. Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 14q23.3
Cellular Component: plasma membrane; cytosol
Molecular Function: calmodulin binding; protein binding; protein kinase A binding; adenylate cyclase binding
Biological Process: synaptic transmission; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; signal transduction; regulation of insulin secretion; protein targeting
Product References and Citations for anti-AKAP5 antibody
(1) Gold,M.G., Stengel,F., Nygren,P.J., et al. Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex. Proc. Natl. Acad. Sci. U.S.A. 108 (16), 6426-6431 (2011).
Research Articles on AKAP5
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Products associated with anti-AKAP5 antibody
Pathways associated with anti-AKAP5 antibody
Diseases associated with anti-AKAP5 antibody
Organs/Tissues associated with anti-AKAP5 antibody
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