Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow AKR1B1 rightarrow Polyclonal AKR1B1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • XRCC1 Antibody
 • Trk B (Ab-705) Antibody
 • ZNF292 Antibody
 • LKB1 (Ab-189) Antibody
 • HDAC5 (Ab-259) Antibody
 • Pregnancy Specific beta1 Glycoprotein 3 (PSG3) ELISA Kit
 • Prostaglandin E Receptor 2 (EP2) ELISA Kit
 • Basic Leucine Zipper Transcription Factor Atf-Like (BATF) ELISA Kit
 • General Transcription Factor IIb (GTFIIB) ELISA Kit
 • Receptor For Advanced Glycatiom End Products (RAGE) ELISA Kit
 • Collagen Type II (COL2) ELISA Kit
 • Osteocalcin-Bone Gla Protein (OT-BGP) ELISA Kit
 • Infectious Mononucleosis Igi (IM IgM) ELISA Kit
 • Reticulin Antibody (ARA) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-AKR1B1 antibody :: Rabbit AKR1B1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS540881
Western Blot (WB)
Unit / Price
0.1 mg Affinity-Purified  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AKR1B1, Polyclonal Antibody

 Also Known As   

AKR1B1 Antibody Affinity Purified

 Product Synonym Names    ADR; AKR1B 1; Aldehyde reductase; Aldo keto reductase family 1, member B1; Aldose reductase; aldr 1; ALR2; AR; Lii5 2 CTCL tumor antigen; low Km aldose reductase; MGC1804 antibody
 Product Gene Name   

anti-AKR1B1 antibody

[Similar Products]
 Antibody/Peptide Pairs    AKR1B1 peptide (MBS542348) is used for blocking the activity of AKR1B1 antibody (MBS540881)
 Matching Pairs    Antibody: AKR1B1 (MBS540881)
Positive Control: AKR1B1 (MBS542517)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    103880
 3D Structure    ModBase 3D Structure for P15121
Section Bar
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Form/Format    Affinity Purified
 Concentration    0.55-0.75 ug/ul in antibody stabilization buffer (lot specific)
Section Bar
 Immunogen    Synthetic peptide taken within amino acid region 250-350 on human Aldo-keto reductase family 1, member B1 protein.
 Expression    Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.
 Molecular Function    Aldo-keto reductase (NADP) activity, glyceraldehyde oxidoreductase activity, electron carrier activity
 Structure    Monomer
 Subcellular Location    Cytoplasm
Section Bar
 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-AKR1B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-AKR1B1 antibody

   Affinity Purified Aldo-keto reductase family 1, member B1 Antibody
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
 Product Categories/Family for anti-AKR1B1 antibody    Primary Antibodies; Metabolism & Homeostasis; AKR1B1 Antibody
 Applications Tested/Suitable for anti-AKR1B1 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-AKR1B1 antibody    Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500
Section Bar
 Western Blot (WB) of anti-AKR1B1 antibody    anti-AKR1B1 antibody Western Blot (WB) (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for AKR1B1. It may not necessarily be applicable to this product.
 NCBI GI #    13529257
 NCBI GeneID    231
 NCBI Accession #    AAH05387.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P15121 [Other Products]
 UniProt Secondary Accession #    Q5U031; Q6FGA4; Q6ICP2; Q9BS21; Q9UCI9; B2R8N3 [Other Products]
 UniProt Related Accession #    P15121 [Other Products]
 Molecular Weight    35,853 Da
Table BarTOPTable Bar
 NCBI Official Full Name    Aldo-keto reductase family 1, member B1 (aldose reductase)
 NCBI Official Synonym Full Names    aldo-keto reductase family 1 member B
 NCBI Official Symbol    AKR1B1 [Similar Products]
 NCBI Official Synonym Symbols   
AR; ADR; ALR2; ALDR1
[Similar Products]
 NCBI Protein Information    aldose reductase
 UniProt Protein Name    Aldose reductase
 UniProt Synonym Protein Names   
Aldehyde reductase; Aldo-keto reductase family 1 member B1
 Protein Family    Aldose reductase
 UniProt Gene Name    AKR1B1 [Similar Products]
 UniProt Synonym Gene Names    ALDR1; AR [Similar Products]
 UniProt Entry Name    ALDR_HUMAN
Section Bar
 NCBI Summary for AKR1B1    This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]
Section Bar
 UniProt Comments for AKR1B1    AKR1B1: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. Belongs to the aldo/keto reductase family.

Protein type: Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - pyruvate; Lipid Metabolism - glycerolipid; EC 1.1.1.21; Oxidoreductase

Chromosomal Location of Human Ortholog: 7q35

Cellular Component: cytoplasm; cytosol; extracellular space; mast cell granule; nucleoplasm; perinuclear region of cytoplasm

Molecular Function: aldehyde reductase activity; aldo-keto reductase activity; electron carrier activity; glyceraldehyde oxidoreductase activity

Biological Process: C21-steroid hormone biosynthetic process; carbohydrate metabolic process; fructose biosynthetic process; maternal process involved in pregnancy; naphthalene metabolic process; norepinephrine metabolic process; positive regulation of JAK-STAT cascade; positive regulation of smooth muscle cell proliferation; response to stress; response to water deprivation; sorbitol biosynthetic process; stress-activated protein kinase signaling pathway; tissue homeostasis
Table BarTOPTable Bar
 Research Articles on AKR1B1    1. Meta-analysis shows that the AR rs759853 polymorphism may correlate with the susceptibility of DN. However, data do not support the association between this DNA variation and the progression of DN.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Pathways associated with anti-AKR1B1 antibodyDiseases associated with anti-AKR1B1 antibody
 Products by Pathway  Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose Biosynthesis Pathway antibodies  Fructose Biosynthesis Pathway Diagram
 Fructose Metabolism Pathway antibodies  Fructose Metabolism Pathway Diagram
 Galactose Metabolism Pathway antibodies  Galactose Metabolism Pathway Diagram
 Galactose Metabolism Pathway antibodies  Galactose Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Diabetes Complications Antibodies  >39 publications with AKR1B1 and Diabetes Complications
 Inflammation Antibodies  >16 publications with AKR1B1 and Inflammation
 Cataract Antibodies  >11 publications with AKR1B1 and Cataract
 Kidney Diseases Antibodies  >9 publications with AKR1B1 and Kidney Diseases
 Disease Models, Animal Antibodies  >8 publications with AKR1B1 and Disease Models, Animal
 Necrosis Antibodies  >7 publications with AKR1B1 and Necrosis
 Breast Neoplasms Antibodies  >7 publications with AKR1B1 and Breast Neoplasms
 Nervous System Diseases Antibodies  >6 publications with AKR1B1 and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >4 publications with AKR1B1 and Carcinoma, Hepatocellular
 Pain Antibodies  >3 publications with AKR1B1 and Pain
Organs/Tissues associated with anti-AKR1B1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >23 publications with AKR1B1 and Blood
 Uterus Antibodies  >16 publications with AKR1B1 and Uterus
 Eye Antibodies  >14 publications with AKR1B1 and Eye
 Liver Antibodies  >13 publications with AKR1B1 and Liver
 Lung Antibodies  >11 publications with AKR1B1 and Lung
 Kidney Antibodies  >10 publications with AKR1B1 and Kidney
 Placenta Antibodies  >8 publications with AKR1B1 and Placenta
 Vascular Antibodies  >8 publications with AKR1B1 and Vascular
 Muscle Antibodies  >8 publications with AKR1B1 and Muscle
 Heart Antibodies  >7 publications with AKR1B1 and Heart
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions