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anti-AKR1B1 antibody :: Rabbit anti-Human AKR1B1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9203885
Unit / Price
0.08 mL  /  $155 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AKR1B1, Polyclonal Antibody

 Also Known As   

AKR1B1 Antibody (C-term)

 Product Synonym Names    Aldose reductase; AR; Aldehyde reductase; Aldo-keto reductase family 1 member B1; AKR1B1; ALDR1
 Product Gene Name   

anti-AKR1B1 antibody

[Similar Products]
 Antibody/Peptide Pairs    AKR1B1 peptide (MBS9224777) is used for blocking the activity of AKR1B1 antibody (MBS9203885)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    290-316
 OMIM    103880
 3D Structure    ModBase 3D Structure for P15121
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This AKR1B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290-316 amino acids from the C-terminal region of human AKR1B1.
 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
 Concentration    Vial Concentration: 2 (lot specific)
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 Antigen Type    Synthetic Peptide
 Crown Antibody    Yes
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-AKR1B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-AKR1B1 antibody

   AKR1B1 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol.
 Product Categories/Family for anti-AKR1B1 antibody    Crown Antibodies; Metabolism; Signal Transduction
 Applications Tested/Suitable for anti-AKR1B1 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blot (WB)

 Application Notes for anti-AKR1B1 antibody    WB~~1:1000
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 Western Blot (WB) of anti-AKR1B1 antibody    AKR1B1 Antibody (C-term) western blot analysis in A375 cell line and human placenta tissue lysates (35ug/lane).This demonstrates the AKR1B1 antibody detected the AKR1B1 protein (arrow).
anti-AKR1B1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-AKR1B1 antibody    Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with AKR1B1 antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
anti-AKR1B1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-AKR1B1 antibody    Confocal immunofluorescent analysis of AKR1B1 Antibody (C-term) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
anti-AKR1B1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for AKR1B1. It may not necessarily be applicable to this product.
 NCBI GI #    4502049
 NCBI GeneID    231
 NCBI Accession #    NP_001619.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001628.2 [Other Products]
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 UniProt Primary Accession #    P15121 [Other Products]
 UniProt Secondary Accession #    Q5U031; Q6FGA4; Q6ICP2; Q9BS21; Q9UCI9; B2R8N3 [Other Products]
 UniProt Related Accession #    P15121 [Other Products]
 Molecular Weight    35853
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 NCBI Official Full Name    aldose reductase
 NCBI Official Synonym Full Names    aldo-keto reductase family 1, member B1 (aldose reductase)
 NCBI Official Symbol    AKR1B1 [Similar Products]
 NCBI Official Synonym Symbols   
AR; ADR; ALR2; ALDR1
[Similar Products]
 NCBI Protein Information    aldose reductase
 UniProt Protein Name    Aldose reductase
 UniProt Synonym Protein Names   
Aldehyde reductase; Aldo-keto reductase family 1 member B1
 Protein Family    Aldose reductase
 UniProt Gene Name    AKR1B1 [Similar Products]
 UniProt Synonym Gene Names    ALDR1; AR [Similar Products]
 UniProt Entry Name    ALDR_HUMAN
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 NCBI Summary for AKR1B1    This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]
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 UniProt Comments for AKR1B1    AKR1B1: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. Belongs to the aldo/keto reductase family.

Protein type: EC 1.1.1.21; Lipid Metabolism - glycerolipid; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - pentose and glucuronate interconversions; Oxidoreductase; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - fructose and mannose

Chromosomal Location of Human Ortholog: 7q35

Cellular Component: nucleoplasm; extracellular space; cytoplasm; cytosol

Molecular Function: glyceraldehyde oxidoreductase activity; electron carrier activity; aldo-keto reductase activity; aldehyde reductase activity

Biological Process: steroid metabolic process; carbohydrate metabolic process; response to stress; C21-steroid hormone biosynthetic process
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Product References and Citations for anti-AKR1B1 antibody

   Steuber,H.,J. Mol. Biol. 379 (5), 991-1016 (2008)
Gleissner,C.A.,Arterioscler. Thromb. Vasc. Biol. 28 (6), 1137-1143 (2008)
Grundmann,U.,DNA Cell Biol. 9 (3), 149-157 (1990)
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 Research Articles on AKR1B1    1. Data conclude that AKR1B1 and TM6SF1 may serve as candidate methylation biomarkers for early breast cancer detection.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-AKR1B1 antibodyDiseases associated with anti-AKR1B1 antibody
 Products by Pathway  Pathway Diagram
 D-sorbitol Degradation II Pathway antibodies  D-sorbitol Degradation II Pathway Diagram
 D-sorbitol Degradation II Pathway antibodies  D-sorbitol Degradation II Pathway Diagram
 D-sorbitol Degradation II Pathway antibodies  D-sorbitol Degradation II Pathway Diagram
 D-sorbitol Degradation II Pathway antibodies  D-sorbitol Degradation II Pathway Diagram
 D-sorbitol Degradation II Pathway antibodies  D-sorbitol Degradation II Pathway Diagram
 D-sorbitol Degradation II Pathway antibodies  D-sorbitol Degradation II Pathway Diagram
 D-sorbitol Degradation II Pathway antibodies  D-sorbitol Degradation II Pathway Diagram
 D-sorbitol Degradation II Pathway antibodies  D-sorbitol Degradation II Pathway Diagram
 D-sorbitol Degradation II Pathway antibodies  D-sorbitol Degradation II Pathway Diagram
 D-sorbitol Degradation II Pathway antibodies  D-sorbitol Degradation II Pathway Diagram
 Disease Name  Pubmed Publications
 Diabetes Complications Antibodies  >38 publications with AKR1B1 and Diabetes Complications
 Inflammation Antibodies  >12 publications with AKR1B1 and Inflammation
 Cataract Antibodies  >10 publications with AKR1B1 and Cataract
 Hyperglycemia Antibodies  >9 publications with AKR1B1 and Hyperglycemia
 Kidney Diseases Antibodies  >8 publications with AKR1B1 and Kidney Diseases
 Necrosis Antibodies  >7 publications with AKR1B1 and Necrosis
 Nervous System Diseases Antibodies  >6 publications with AKR1B1 and Nervous System Diseases
 Breast Neoplasms Antibodies  >5 publications with AKR1B1 and Breast Neoplasms
 Pain Antibodies  >3 publications with AKR1B1 and Pain
 Adenocarcinoma Antibodies  >3 publications with AKR1B1 and Adenocarcinoma
Organs/Tissues associated with anti-AKR1B1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >22 publications with AKR1B1 and Blood
 Uterus Antibodies  >15 publications with AKR1B1 and Uterus
 Eye Antibodies  >14 publications with AKR1B1 and Eye
 Liver Antibodies  >12 publications with AKR1B1 and Liver
 Lung Antibodies  >11 publications with AKR1B1 and Lung
 Kidney Antibodies  >9 publications with AKR1B1 and Kidney
 Muscle Antibodies  >8 publications with AKR1B1 and Muscle
 Placenta Antibodies  >7 publications with AKR1B1 and Placenta
 Vascular Antibodies  >7 publications with AKR1B1 and Vascular
 Heart Antibodies  >7 publications with AKR1B1 and Heart
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