P52895.3
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,748 Da
NCBI Official Full Name
Aldo-keto reductase family 1 member C2
NCBI Official Synonym Full Names
aldo-keto reductase family 1, member C2
NCBI Official Synonym Symbols
DD; DD2; TDD; BABP; DD-2; DDH2; HBAB; HAKRD; MCDR2; SRXY8; DD/BABP; AKR1C-pseudo [Similar Products]
NCBI Protein Information
aldo-keto reductase family 1 member C2
UniProt Protein Name
Aldo-keto reductase family 1 member C2
UniProt Synonym Protein Names
3-alpha-HSD3; Chlordecone reductase homolog HAKRD; Dihydrodiol dehydrogenase 2; DD-2; DD2; Dihydrodiol dehydrogenase/bile acid-binding protein; DD/BABP; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC:1.3.1.20
UniProt Synonym Gene Names
UniProt Entry Name
AK1C2_HUMAN
NCBI Summary for AKR1C2
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for AKR1C2
Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.
Research Articles on AKR1C2
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Pathways associated with anti-AKR1C2 antibody
Diseases associated with anti-AKR1C2 antibody
Organs/Tissues associated with anti-AKR1C2 antibody
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