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anti-AKR7A2 antibody :: Rabbit anti-Human, Mouse AKR7A2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7043862
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AKR7A2, Polyclonal Antibody

★Popular Item★
 Also Known As   

AKR7A2 Antibody

 Product Synonym Names    Aflatoxin B1 aldehyde reductase member 2; AFB1 aldehyde reductase 1; AFB1-AR 1; Aldoketoreductase 7; Succinic semialdehyde reductase; SSA reductase; AKR7A2; AFAR; AFAR1; AKR7
 Product Gene Name   

anti-AKR7A2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603418
 3D Structure    ModBase 3D Structure for O43488
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Aflatoxin B1 aldehyde reductase member 2 protein (C-260AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-27765 / sc-27766 / sc-32944
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-AKR7A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-AKR7A2 antibody

   Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
 Applications Tested/Suitable for anti-AKR7A2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-AKR7A2 antibody    Western blot
All lanes: AKR7A2 antibody at 0.88 ug/ml
Lane 1: Mouse small intestine tissue
Lane 2: Mouse liver tissue
Lane 3: Mouse gonadal tissue
Lane 4: A431 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 40 kDa
Observed band size: 40 kDa

anti-AKR7A2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-AKR7A2 antibody    Immunohistochemistry of paraffin-embedded human liver tissue using MBS7043862 at dilution 1:100
anti-AKR7A2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-AKR7A2 antibody    Immunohistochemistry of paraffin-embedded human liver cancer using MBS7043862 at dilution 1:100
anti-AKR7A2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for AKR7A2. It may not necessarily be applicable to this product.
 NCBI GI #    41327764
 NCBI GeneID    8574
 NCBI Accession #    NP_003680.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003689.3 [Other Products]
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 UniProt Primary Accession #    O43488 [Other Products]
 UniProt Secondary Accession #    O75749; Q5TG63 [Other Products]
 UniProt Related Accession #    O43488 [Other Products]
 Molecular Weight    39,589 Da
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 NCBI Official Full Name    aflatoxin B1 aldehyde reductase member 2 isoform 1
 NCBI Official Synonym Full Names    aldo-keto reductase family 7 member A2
 NCBI Official Symbol    AKR7A2 [Similar Products]
 NCBI Official Synonym Symbols   
AFAR; AKR7; AFAR1; AFB1-AR1
[Similar Products]
 NCBI Protein Information    aflatoxin B1 aldehyde reductase member 2
 UniProt Protein Name    Aflatoxin B1 aldehyde reductase member 2
 UniProt Synonym Protein Names   
AFB1 aldehyde reductase 1; AFB1-AR 1; Aldoketoreductase 7; Succinic semialdehyde reductase; SSA reductase
 Protein Family    Aflatoxin B1 aldehyde reductase
 UniProt Gene Name    AKR7A2 [Similar Products]
 UniProt Synonym Gene Names    AFAR; AFAR1; AKR7; AFB1-AR 1; SSA reductase [Similar Products]
 UniProt Entry Name    ARK72_HUMAN
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 NCBI Summary for AKR7A2    The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
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 UniProt Comments for AKR7A2    AKR7A2: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2- nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.

Protein type: Oxidoreductase; EC 1.1.1.n11

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: cytosol

Molecular Function: aldehyde reductase activity; aldo-keto reductase activity; electron carrier activity; phenanthrene-9,10-epoxide hydrolase activity

Biological Process: aldehyde metabolic process; carbohydrate metabolic process; xenobiotic metabolic process
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 Research Articles on AKR7A2    1. induced expression in human monocytes following exposure to Aflatoxin B1
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-AKR7A2 antibodyDiseases associated with anti-AKR7A2 antibody
 Products by Pathway  Pathway Diagram
 Aflatoxin B1 Metabolism Pathway antibodies  Aflatoxin B1 Metabolism Pathway Diagram
 Aflatoxin Activation And Detoxification Pathway antibodies  Aflatoxin Activation And Detoxification Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Metapathway Biotransformation antibodies  Metapathway Biotransformation Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with AKR7A2 and Nervous System Diseases
 Pancreatic Neoplasms Antibodies  >1 publications with AKR7A2 and Pancreatic Neoplasms
 Renal Insufficiency Antibodies  >1 publications with AKR7A2 and Renal Insufficiency
Organs/Tissues associated with anti-AKR7A2 antibody
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >6 publications with AKR7A2 and Muscle
 Brain Antibodies  >6 publications with AKR7A2 and Brain
 Kidney Antibodies  >5 publications with AKR7A2 and Kidney
 Heart Antibodies  >5 publications with AKR7A2 and Heart
 Testis Antibodies  >3 publications with AKR7A2 and Testis
 Lung Antibodies  >3 publications with AKR7A2 and Lung
 Pancreas Antibodies  >2 publications with AKR7A2 and Pancreas
 Spleen Antibodies  >2 publications with AKR7A2 and Spleen
 Blood Antibodies  >1 publications with AKR7A2 and Blood
 Prostate Antibodies  >1 publications with AKR7A2 and Prostate
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