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anti-AKT1 antibody :: Rabbit anti-Human AKT1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS641561 anti-AKT1 antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AKT1, Polyclonal Antibody

 Also Known As   

AKT1, phosphorylated (Thr308) (AKT1, PKB, RAC, RAC-alpha serine/threonine-protein kinase, Protein kinase B, Protein kinase B alpha, Proto-oncogene c-Akt, RAC-PK-alpha)

 Product Synonym Names    Anti -AKT1, phosphorylated (Thr308) (AKT1, PKB, RAC, RAC-alpha serine/threonine-protein kinase, Protein kinase B, Protein kinase B alpha, Proto-oncogene c-Akt, RAC-PK-alpha)
 Product Gene Name   

anti-AKT1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 14; NC_000014.8 (105235686..105262080, complement). Location: 14q32.32
 OMIM    114480
 3D Structure    ModBase 3D Structure for P31749
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Human
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
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 Immunogen    Phospho-AKT1 (Thr308) Antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected surrounding Thr308 of human AKT1.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-AKT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-AKT1 antibody

   The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].
 Product Categories/Family for anti-AKT1 antibody    Antibodies; Abs to Protein Kinases
 Applications Tested/Suitable for anti-AKT1 antibody   

ELISA (EL/EIA), Immunofluorescence (IF), Gel Shift Assay (GS/EMSA)

 Application Notes for anti-AKT1 antibody    Suitable for use in Immunofluorescence, Dot Blot, ELISA
Dilution: ELISA: 1:1,000
Dot blot 1:100-500
Immunofluorescence: 1:10-50
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NCBI/Uniprot data below describe general gene information for AKT1. It may not necessarily be applicable to this product.
 NCBI GI #    18027298
 NCBI GeneID    207
 NCBI Accession #    AAL55732.1 [Other Products]
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 UniProt Primary Accession #    P31749 [Other Products]
 UniProt Secondary Accession #    Q9BWB6; B2RAM5 [Other Products]
 UniProt Related Accession #    P31749 [Other Products]
 Molecular Weight    55,686 Da [Similar Products]
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 NCBI Official Full Name    AKT1
 NCBI Official Synonym Full Names    v-akt murine thymoma viral oncogene homolog 1
 NCBI Official Symbol    AKT1 [Similar Products]
 NCBI Official Synonym Symbols   
AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA
[Similar Products]
 NCBI Protein Information    RAC-alpha serine/threonine-protein kinase; PKB alpha; RAC-PK-alpha; proto-oncogene c-Akt; protein kinase B alpha; rac protein kinase alpha
 UniProt Protein Name    RAC-alpha serine/threonine-protein kinase
 UniProt Synonym Protein Names   
Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha
 Protein Family    Potassium channel
 UniProt Gene Name    AKT1 [Similar Products]
 UniProt Synonym Gene Names    PKB; RAC; PKB; PKB alpha [Similar Products]
 UniProt Entry Name    AKT1_HUMAN
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 NCBI Summary for AKT1    The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
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 UniProt Comments for AKT1    Akt1: an oncogenic AGC kinase that plays a critical role in regulating cell survival and metabolism in many different signaling pathways. Dual phosphorylation is required for its activation. T308 is phosphorylated by PDK1 in the PI3 kinase pathway, and S473 is phosphorylated by mTOR in the mTORC2 pathway. The 'Lys-63'-linked ubiquitination of AKT1 by TRAF6 is important for its translocation to the plasma membrane, phosphorylation, and activation. When Akt is fully phosphorylated it translocates into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its proteosomal degradation. Hyperactive or overexpressed in a number of cancers including breast, prostate, lung, pancreatic, liver, ovarian and colorectal. Over 160 protein substrates are known including many that regulate transcription, metabolism, apoptosis, cell cycle, and growth.

Protein type: EC 2.7.11.1; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; AGC group; AKT family

Chromosomal Location of Human Ortholog: 14q32.32

Cellular Component: microtubule cytoskeleton; nucleoplasm; mitochondrion; cytoplasm; plasma membrane; spindle; intercellular junction; nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; identical protein binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; enzyme binding; protein kinase C binding; nitric-oxide synthase regulator activity; protein serine/threonine/tyrosine kinase activity; kinase activity; phosphatidylinositol-3,4-bisphosphate binding; ATP binding; protein kinase activity

Biological Process: negative regulation of JNK cascade; positive regulation of nitric oxide biosynthetic process; regulation of myelination; nerve growth factor receptor signaling pathway; protein ubiquitination; glucose homeostasis; regulation of cell migration; protein amino acid phosphorylation; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; germ cell development; positive regulation of glucose import; cell projection organization and biogenesis; protein catabolic process; maternal placenta development; response to food; platelet activation; glycogen biosynthetic process; fibroblast growth factor receptor signaling pathway; positive regulation of nitric-oxide synthase activity; positive regulation of blood vessel endothelial cell migration; glucose metabolic process; positive regulation of lipid biosynthetic process; positive regulation of cell growth; insulin-like growth factor receptor signaling pathway; cellular response to insulin stimulus; response to heat; T cell costimulation; positive regulation of fat cell differentiation; negative regulation of protein kinase activity; striated muscle cell differentiation; positive regulation of transcription factor activity; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; response to oxidative stress; regulation of nitric-oxide synthase activity; negative regulation of apoptosis; negative regulation of autophagy; negative regulation of fatty acid beta-oxidation; translation; apoptosis; protein amino acid autophosphorylation; regulation of glycogen biosynthetic process; positive regulation of cellular protein metabolic process; positive regulation of glycogen biosynthetic process; negative regulation of cell size; glucose transport; negative regulation of caspase activity; signal transduction; nitric oxide metabolic process; regulation of translation; apoptotic mitochondrial changes; protein kinase B signaling cascade; cell differentiation; inflammatory response; nitric oxide biosynthetic process; activated T cell apoptosis; aging; epidermal growth factor receptor signaling pathway; negative regulation of proteolysis; phosphoinositide-mediated signaling; myelin maintenance in the peripheral nervous system; protein modification process; positive regulation of peptidyl-serine phosphorylation; endocrine pancreas development; osteoblast differentiation; G-protein coupled receptor protein signaling pathway; cell proliferation; peptidyl-serine phosphorylation; protein import into nucleus, translocation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of vasoconstriction; insulin receptor signaling pathway; innate immune response; gene expression; positive regulation of protein amino acid phosphorylation; vascular endothelial growth factor receptor signaling pathway; blood coagulation; hyaluronan metabolic process; phosphorylation

Disease: Schizophrenia; Cowden Syndrome 6; Proteus Syndrome; Breast Cancer; Ovarian Cancer
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 Research Articles on AKT1    1. Analyzed the effects of dual inhibition of mTOR and AKT on the proliferation of HCC cell lines & measured feedback activation of each AKT isoforms after mTOR inhibition in HCC cell lines and enzymatic activity in primary samples from HCC patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to AKT1, phosphorylated (Thr308) (AKT1, PKB, RAC, RAC-alpha serine/threonine-pro
 Catalog #  Product Name  Catalog #  Product Name
 MBS601744  Akt1, PH Domain, Serine-Threonine Phosphorylation (Rac PKa, PKBa)  MBS540391  AKT1 Antibody
 MBS2536176  Akt1 Polyclonal Antibody  MBS2537247  Phospho-Akt1 (T450) Polyclonal Antibody
 MBS8521155  Akt1 Polyclonal Antibody  MBS002033  Rabbit Akt1 (Phospho-Thr450) Antibody
 MBS8241922  Anti-AKT1/2 (pT308/309) Antibody  MBS9221025  Mouse Akt1 Antibody (N-term) Blocking Peptide
 MBS9208927  Phospho-AKT1 (S473) Antibody  MBS8216845  AKT1S1 siRNA (Mouse)
Products associated with anti-AKT1 antibodyPathways associated with anti-AKT1 antibody
 Reference Product  PubMed Publications
 PTEN antibody  >452 publications with AKT1 and PTEN
 MTOR antibody  >366 publications with AKT1 and MTOR
 FOXO1 antibody  >121 publications with AKT1 and FOXO1
 CDKN1B antibody  >108 publications with AKT1 and CDKN1B
 MDM2 antibody  >44 publications with AKT1 and MDM2
 TSC2 antibody  >37 publications with AKT1 and TSC2
 TERT antibody  >12 publications with AKT1 and TERT
 GSK3B antibody  >9 publications with AKT1 and GSK3B
 UBC antibody  >6 publications with AKT1 and UBC
 HSP90AA1 antibody  >2 publications with AKT1 and HSP90AA1
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 AKT Phosphorylates Targets In The Cytosol Pathway antibodies  AKT Phosphorylates Targets In The Cytosol Pathway Diagram
 AKT Phosphorylates Targets In The Nucleus Pathway antibodies  AKT Phosphorylates Targets In The Nucleus Pathway Diagram
 AKT-mediated Inactivation Of FOXO1A Pathway antibodies  AKT-mediated Inactivation Of FOXO1A Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
Diseases associated with anti-AKT1 antibodyOrgans/Tissues associated with anti-AKT1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1891 publications with AKT1 and Neoplasms
 Breast Neoplasms Antibodies  >362 publications with AKT1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >317 publications with AKT1 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >278 publications with AKT1 and Nervous System Diseases
 Necrosis Antibodies  >276 publications with AKT1 and Necrosis
 Lung Neoplasms Antibodies  >198 publications with AKT1 and Lung Neoplasms
 Prostatic Neoplasms Antibodies  >184 publications with AKT1 and Prostatic Neoplasms
 Neoplasms, Experimental Antibodies  >175 publications with AKT1 and Neoplasms, Experimental
 Inflammation Antibodies  >154 publications with AKT1 and Inflammation
 Heart Diseases Antibodies  >137 publications with AKT1 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >732 publications with AKT1 and Blood
 Muscle Antibodies  >642 publications with AKT1 and Muscle
 Vascular Antibodies  >628 publications with AKT1 and Vascular
 Brain Antibodies  >451 publications with AKT1 and Brain
 Lung Antibodies  >312 publications with AKT1 and Lung
 Heart Antibodies  >277 publications with AKT1 and Heart
 Liver Antibodies  >256 publications with AKT1 and Liver
 Nerve Antibodies  >233 publications with AKT1 and Nerve
 Prostate Antibodies  >226 publications with AKT1 and Prostate
 Kidney Antibodies  >159 publications with AKT1 and Kidney
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